Progresses in Predicting Post-translational Modification

WITHDRAWN: An insightful recollection since the distorted key theory was born about 23 years ago

“…Journal Pre-proof J o u r n a l P r e -p r o o f Furthermore, a web-server called "HIVcleave" [21] has been established for predicting HIV protease cleavage sites in proteins. Its website address is at Just like the pseudo amino acid components [51-54] and the 5-steps rule [55], which have been stimulated by the development of the sequence bioinformatics, widely and increasingly used in proteome and genome analysis and , it is anticipated that the "distorted key theory" that was stimulated from the structural bioinformatics [187] as well as some pioneering studies [188][189][190][191][192][193][194][195] and their follow-up studies , will be also widely and increasingly used in drug development, particularly for developing peptide drugs [217] and multi-target drugs [218]. Journal Pre-proof Journal Pre-proof J o u r n a l P r e -p r o o f 5 Figure 1 Journal Pre-proof J o u r n a l P r e -p r o o f 6 Figure 2.…”

South Atlantic Anomaly, Ionospheric Signals from Seismic Events

“…Although at the present the reports in this regard from theoretical scientists are more than those from experimental scientists, it is anticipated that, with more experimental data available in future, this kind of reports from experimental scientists will be increasing as well. Particularly, the combined reports between experimental and theoretical approaches, or their compliments to each other, will increasingly appear, as indicated by some very impressive papers [35][36][37][38][39][40][41] and a series of very recent papers (see, e.g., [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56]).…”

Use Chou’s 5-Steps Rule to Predict Remote Homology Proteins by Merging Grey Incidence Analysis and Domain Similarity Analysis

“…To acquire the structural information in a Open Access Natural Science timely manner, a series of 3D protein structures have been developed by means of structural bioinformatics tools (see, e.g., [8][9][10][11][12][13][14][15][16][17][18][19][20]). Meanwhile, facing the explosive growth of biological sequences discovered in the post-genomic age, to timely use them for drug development, a lot of important sequence-based information, such as PTM (posttranslational modification) sites in proteins [21,22], protein-drug interaction in cellular networking [23], DNA-methylation sites [24], recombination spots [25], and sigma-54 promoters [26], have been deducted by various sequential bioinformatics tools such as PseAAC approach [27] and PseKNC approach [28]. Actually, the rapid development in sequential bioinformatics and structural bioinformatics have driven the medicinal chemistry undergoing an unprecedented revolution [29], in which the computational biology has played increasingly important roles in stimulating the development of finding novel drugs.…”