Progression and Regression of Diabetic Retinopathy

Caird, F. I.; Garrett, C J

doi:10.1177/003591576205500613

Cited by 12 publications

(7 citation statements)

References 6 publications

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“…Regression of diabetic retinopathy is well documented. For instance, in 1962 Caird and Garrett 21 noted that in a group of 168 diabetic patients after five years, 36 per cent of eyes showed regression of microaneurysms and 27 per cent of eyes showed regression of haemorrhages and/or exudates. A recent report from the Wisconsin Epidemiologic Study of Diabetic Retinopathy 22 found that regression of diabetic retinopathy is more likely in patients with lower glycosylated haemoglobin and diastolic blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Incidence of diabetic retinopathy in a Hong Kong Chinese population

Song

Liu

Sum

et al. 2011

Clinical and Experimental Optometry

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Background:The aim was to examine the progression and regression of diabetic retinopathy within a four-year period in a Chinese population with type 2 diabetes mellitus in a community optometry clinic in Hong Kong. Methods: During the period May 2005 to November 2009, 5,160 patients with type 2 diabetes mellitus who had attended at least two diabetic retinopathy screening sessions at a community optometry clinic were included as subjects in this study. All had retinal photographs taken of both eyes, which were of sufficiently good quality for grading. For the purpose of this study, diabetic retinopathy grading was based on the results of the worst eye. The main outcomes were the within four-year incidence of diabetic retinopathy and the incidence of progression and regression of diabetic retinopathy. Results: Of the 5,160 subjects in this study, 3,647 had no diabetic retinopathy, while 1,513 had diabetic retinopathy at the baseline visit. Of those 3,647 subjects with no diabetic retinopathy, the within four-year cumulative incidence of any diabetic retinopathy, mild or moderate non-proliferative diabetic retinopathy and sight-threatening diabetic retinopathy was 15.16 per cent, 14.45 per cent, 0.69 per cent and 0.03 per cent, respectively. Of those 1,513 subjects with diabetic retinopathy at baseline, the within four-year progression incidence of diabetic retinopathy was 6.61 per cent and the regression incidence of diabetic retinopathy was 45.54 per cent. Conclusion: The high regression incidence of diabetic retinopathy suggests that it might not be necessary for all patients with diabetes to be screened annually. Other methods to determine the screening frequency for an individual patient should be explored.

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Section: Discussionmentioning

confidence: 99%

Incidence of diabetic retinopathy in a Hong Kong Chinese population

Song

Liu

Sum

et al. 2011

Clinical and Experimental Optometry

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“…35 ' 36 Nevertheless, it was thought that in a prospective study dealing with early stages of diabetic retinopathy this criterion is a valuable index. This choice was justified a posteriori by the progressive increase in the mean number of microaneurysms observed in both groups during the survey.…”

Section: Discussionmentioning

confidence: 99%

Effect of Multiple Daily Insulin Injections on the Course of Diabetic Retinopathy

et al. 1976

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Forty-two diabetic patients on insulin once a day in the earlystage of diabetic retinopathy were randomly assigned to one of two kinds of insulin regimen, i.e., single or multiple daily injections. Retinal changes were quantitatively estimated by counting the microaneurysms (MAs) observed on fluorescein angiograms at the posterior pole of the more diseased eye. Baseline characteristics of the two groups were not significantly different. These included duration of diabetes, age at diagnosis, daily dose of insulin, amount of urinary sugar excreted in 24 hours, fasting Mood sugar (FBS), and number of MAs. During the follow-up (mean duration of three years) the mean yearly progression in the number of MAs was significantly less in the multiple-than in the single-injection group: 1.8 ± 0.7 versus 7.2 ± 1.9 (p<0.01; nonparametric test: p<0.02). Final values were, respectively, MAs: 15.2 ± 4.9; 33.0 ± 7.9; glycosuria (gm./24 hrs): 20.6 ± 2.5; 27.5 ± 4.3; FBS (mg./lOO ml.): 154 ± 15; 195 ± 11. P values comparing the two groups were <0.02, <0.02, and <0.05. Thus, in this clinical trial, made under routine treatment conditions, the use of divided daily insulin injections was effective in improving diabetic control and delaying retinal changes. DIABETES 25:463-69, May, 1976.Prospective studies on the effect of the treatment of diabetes on the course of microangiopathy are scarce but strongly suggest that insulin administration and/or the control of diabetes reduce and delay the development of retinal and glomerular changes in diabetic humans 1 -4 and animals. 5 " 8 Indirect arguments have also been given by biochemists. 9 " 11 Previously retrospective studies have claimed that the quality of diabetes control influences the course of

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“…Spontaneous regression of diabetic retinopathy has been reported by such authors as Caird et al 3 and Burditt et al, 4 while Keen et al 5 mention a high degree of spontaneous "activity," a term by which they express the appearance and disappearance of lesions.…”

Section: Discussionmentioning

confidence: 96%

The Course of Diabetic Retinopathy: A Longitudinal Study

Gerritzen¹

1973

Diabetes

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A prospective study was devoted to the spontaneous course of diabetic retinopathy. The retinas of 459 diabetics were photographed every two years for a total follow-up period, planned beforehand, of eight years.For two-year intervals progression of retinopathy was found in 14 to 29 per cent, a stationary picture in 60 to 69 per-cent, and amelioration in 7 to 17 per cent of cases. For four-year intervals these percentages were 32 to 39, 47 to 57, and 10 to 12, for six-year intervals 39-50, 40-47, and 10-14, respectively. During the total eight-year period, 48 per cent progressed, 38 per cent remained stationary, and 14 per cent improved. When the patients in whom retinopathy developed during the investigation were included, the percentages changed numerically without altering the general trend. The influence of the dropout of patients on the results is emphasized.The results are compared with the results of other prospective studies. DIABETES 22:122-28, February, 1973.

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Progression and Regression of Diabetic Retinopathy

Cited by 12 publications

References 6 publications

Incidence of diabetic retinopathy in a Hong Kong Chinese population

Incidence of diabetic retinopathy in a Hong Kong Chinese population

Effect of Multiple Daily Insulin Injections on the Course of Diabetic Retinopathy

The Course of Diabetic Retinopathy: A Longitudinal Study

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