Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting 在中国初级保健机构中合并以及不合并高血压的受试者从空腹血糖受损进展到2型糖尿病的调查

Abstract

Overall, more than one-fifth of IFG subjects in the primary care setting developed T2DM within 5 years. Health care professionals can target interventions to patients with risk factors for disease progression.

Progression from optimal blood glucose and pre-diabetes to type 2 diabetes in a high risk population with or without hypertension in Isfahan, Iran

“…To the best of our knowledge, this is the first study to report on progression rates from NGT, isolated IFG, isolated IGT, or combined IFG/IGT with or without HTN in a high risk population without T2D in Iran. In contrast to the findings of two other studies, we showed concomitant HTN did not appear to be a more robust predictor of progression to T2D [5,6]. Estimates of progression to diabetes will depend upon the methodological factors, the definition of the isolated IFG, isolated IGT, and combined IFG/IGT and diabetes used, unknown time spent with isolated IFG, isolated IGT, and pre-diabetes, sample size, and the composition of the community examined by age and gender, making comparisons between studies of limited values.…”

“…Estimates of progression to diabetes will depend upon the methodological factors, the definition of the isolated IFG, isolated IGT, and combined IFG/IGT and diabetes used, unknown time spent with isolated IFG, isolated IGT, and pre-diabetes, sample size, and the composition of the community examined by age and gender, making comparisons between studies of limited values. Fu et al [5] reported that IFG predicted the development of T2D with an incidence rate of 0.047 in hypertensive individuals and 0.031 in non-hypertensive individuals in a Hong Kong Chinese primary care setting. In a large national managed care claims database, Francis et al [6] examined the healthcare utilization and cost burden of patients with pre-diabetes, with and without co-morbid HTN, who progressed to T2D.…”

“…Although there are not many supporting evidences on the progression rate from NGT or pre-diabetes to T2D in individuals with or without HTN [5,6], the role of concomitant HTN and pre-diabetes as a risk factor for progression to T2D remains unsettled. Francis et al [6] reported that pre-diabetic patients with concomitant HTN were significantly more likely to progress to T2D.…”

“…Francis et al [6] reported that pre-diabetic patients with concomitant HTN were significantly more likely to progress to T2D. A recent study performed in Chinese subjects revealed that individuals with impaired fasting glucose (IFG) were more likely to develop T2D if they were hypertensive [5]. However, while these two studies [5,6] referred to co-morbid HTN as a predictor of progression to T2D, it is likely that genetic factors also influence HTN and T2D.…”

“…A recent study performed in Chinese subjects revealed that individuals with impaired fasting glucose (IFG) were more likely to develop T2D if they were hypertensive [5]. However, while these two studies [5,6] referred to co-morbid HTN as a predictor of progression to T2D, it is likely that genetic factors also influence HTN and T2D. HTN and T2D have similar risk factors such as adiposity that are determined by genetic and early environmental influences.…”