2002
DOI: 10.1016/s0304-3835(01)00757-1
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Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor

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Cited by 108 publications
(112 citation statements)
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References 24 publications
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“…Laminin-5g2 serves as migrating substrate in neoplasia and stimulates invasion after having been cleaved by, for example, MMP-2, 18,19 whereas mutational loss of p16 is a frequent early event in the development of SCC. 20 …”
mentioning
confidence: 99%
“…Laminin-5g2 serves as migrating substrate in neoplasia and stimulates invasion after having been cleaved by, for example, MMP-2, 18,19 whereas mutational loss of p16 is a frequent early event in the development of SCC. 20 …”
mentioning
confidence: 99%
“…It is generally believed that squamous cell carcinoma can emerge from the precancerous lesion actinic keratosis, since the skin lesion mainly occurs on chronically sun-exposed sites as squamous cell carcinoma. 2 UV-type p53 mutations are the, so far known, most common genetic alteration in squamous cell carcinoma. 1 Another tumor suppressor gene commonly altered besides p53 in tumors is p16 INK4a .…”
mentioning
confidence: 99%
“…5,6 Loss of heterozygosity of the 9p21 region has also been observed in squamous carcinomas of the skin. 2,7 The main biological function of p16 INK4a is to regulate the cell cycle by binding to cyclin-dependent kinases (cdk) 4/6. This prevents the formation of an active cyclin D-cdk4/6 complex.…”
mentioning
confidence: 99%
“…Nos últimos anos a literatura vem apresentando estudos envolvendo o cromossomo e seu locus, demonstrando que é freqüente a ocorrência de anormalidades nos genes, assim como alterações na expressão da proteína nas células dos diversos tumores acima descritos (CHEN et al, 1999;MORTIER et al, 2002).…”
Section: P16unclassified
“…Desta forma, é esperado que a ausência ou inativação da p16 (na expressão gênica, na estrutura ou função da proteína) resulte em rompimento do controle do ciclo celular, com conseqüente desenvolvimento do tumor, o que está associado com carcinogênese de tumores que mostram deficiência da p16 (PAPADIMITRAKOPOULOU et al, 1997;MORTIER et al, 2002;WING YUEN et al, 2002;AI et al, 2003).…”
Section: P16unclassified