Progression of aortic valve sclerosis to aortic stenosis

Faggiano, Pompilio; Antonini‐Canterin, Francesco; Erlicher, A; Romeo, Cristina; Cervesato, Eugenio; Pavan, Daniela; Piazza, Rita; Huang, Guoqiang; Nicolosi, Gian Luigi

doi:10.1016/s0002-9149(02)03011-4

Cited by 97 publications

(63 citation statements)

References 12 publications

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“…The group with early-stage CAVD comprised subjects with calcification on one or no leaflet and peak aortic transvalvular flow velocity o2 m s À1 (n¼157). 6,[17][18][19] The late-stage CAVD group comprised subjects with two or three calcified aortic valves and/or with peak aortic transvalvular flow velocity of X2 m s À1 (n¼399). Eleven patients had bicuspid aortic valve, and all met the criteria for late-stage CAVD.…”

Section: Methods Subjectsmentioning

confidence: 99%

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Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Yamamoto

Yoshida

et al. 2010

Hypertens Res

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Calcific aortic valve disease (CAVD) is the most common etiology of acquired valvular heart disease, and hypertension is a principal underlying disease. The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis is a retrospective observational study to clarify the prognostic factors for progression of CAVD in Japanese. Data from 556 subjects who met the following criteria were analyzed: (1) X50 years old; (2) calcification in any aortic valve leaflet or peak aortic jet velocity X2 m s À1 on an echocardiographic study performed between July 2004 and June 2007; and (3) availability of earlier echocardiographic data from within the previous 2-5 years to assess the progression of CAVD. The subjects were divided into two groups according to CAVD severity on the preceding echocardiographic examination. In early-stage subjects with calcification in one or zero leaflets who were without aortic stenosis on the preceding echocardiographic study (n¼157), the prognostic factors for progression were the following: (1) no use of angiotensin receptor blockers (ARB) and (2) use of warfarin. In late-stage subjects with calcification in two or three leaflets and/or aortic stenosis on the preceding echocardiographic study (n¼399), progression was observed in females and in subjects with low hemoglobin and a concentric left ventricle. There was no relation between medications and changes in CAVD. Prognostic factors for the progression of CAVD were different between the early and late stages. Initiation of ARB treatment during the early stage may be effective, and we should be vigilant about progression of CAVD in patients treated with warfarin.

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Section: Methods Subjectsmentioning

confidence: 99%

“…17,20 In the early-stage group, progression was defined as the appearance of two or three newly calcified leaflets or the onset of aortic stenosis (peak aortic transvalvular flow velocity of X2 m s À1 ) at follow-up.…”

Section: Methods Subjectsmentioning

confidence: 99%

Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

Yamamoto

Yoshida

et al. 2010

Hypertens Res

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“…Aortic valve sclerosis (i.e. aortic valve thickening and calcification without pressure gradient) progresses to haemodynamically significant AS in many patients 4 , and it represents a marker of increased risk for cardiovascular events 5 . For many years, it was believed that AS had a long asymptomatic period, followed by a shorter symptomatic period, usually associated with severe narrowing of the aortic valve orifice.…”

Section: Statin Therapy For Calcifi C Aortic Stenosis?mentioning

confidence: 99%

“…For many years, it was believed that AS had a long asymptomatic period, followed by a shorter symptomatic period, usually associated with severe narrowing of the aortic valve orifice. Recent studies have shown that the progression of AS is largely unpredictable in the individual patient: in some cases it may be very slow, in others rather fast 4 .…”

Section: Statin Therapy For Calcifi C Aortic Stenosis?mentioning

confidence: 99%

The role of statin treatment in valvular heart disease: is the jury still out?

et al. 2013

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Valvular heart disease (VHD) represents a signifi cant burden within the spectrum of cardiovascular diseases. In recent years, there has been a great interest in fi nding medical treatments able to slow the progression of VHD. The negative results of several large randomized trials failing to demonstrate a benefi t of such therapies, has led to a decrease of interest in this fi eld. However, fi nding a medical treatment capable of preventing VHD progression is still a hot topic, due to the important clinical implications. We believe that the jury is still out on the debate about the role of statin therapy in VHD, considering also recently published studies providing new information with future implications for the treatment of this disease process. This article gives an overview of the published evidence about the role of hydroxymethylglutaryl coenzyme-A reductase inhibitors on delaying progressive valve dysfunction. A preventive therapy, which could infl uence not only the haemodynamic progression of valve disease, but also the cardiovascular outcome, is warranted. Large, prospective, randomized trials are needed to properly evaluate the role of statins in the early stages of valvular heart disease.

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“…В общей популяции стеноз устья аорты диагностируется у 3-7% пациентов, распространенность его увеличивается с воз-растом, достигая 15-20% в группе старше 80 лет [3]. Учитывая, что нередко патология выявляет-ся у людей с противопоказаниями к открытому хирургическому вмешательству (выраженная со-путствующая патология, заведомо отрицатель-ный прогноз исхода операции на открытом серд-це с искусственным кровообращением), важное значение приобретает транскатетерная имплан-тация аортального клапана (ТИАК).…”

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