Progression of Articular Cartilage Degeneration after Application of Muscle Stretch

Dias, Carolina Náglio Kalil; Renner, A; Santos, Anderson Amaro dos; Vasilceac, Fernando Augusto; Mattiello, Stela Márcia

doi:10.3109/03008207.2011.610476

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…29,38 In this context, our immunhistochemistry findings after 50 J∕cm 2 irradiation appeared to be a predictive factor for response to treatment. However, immuhistochemistry showed that, 8-weeks postsurgery, a higher expression of Col-1 was observed in control animals and laser treated animals, at 10 J∕cm 2 , suggesting a positive effect of the LLLT at 50 J∕cm 2 .…”

Section: Discussionmentioning

confidence: 69%

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

et al. 2013

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The aim of this study was to evaluate the effects of laser phototherapy on the degenerative modifications on the articular cartilage after the anterior cruciate ligament transection (ACLT) in the knee of rats. Eighty male rats (Wistar) were distributed into four groups: intact control group (IG), injured control group (CG), injured laser treated group at 10 J/cm(2) (L10), and injured laser treated group at 50 J/cm(2) (L50). Animals were distributed into two subgroups, sacrificed in 5 and 8 weeks postsurgery. The ACLT was used to induce knee osteoarthritis in rats. After 2 weeks postsurgery, laser phototherapy initiated and it was performed for 15 and 30 sessions. The histological findings revealed that laser irradiation, especially at 10 J/cm(2), modulated the progression of the degenerative process, showing a better cartilage structure and lower number of condrocytes compared to the other groups. Laser phototherapy was not able to decrease the degenerative process measured by Mankin score and prevent the increase of cartilage thickness related to the degenerative process. Moreover, it did not have any effect in the biomodulation of the expression of markers IL1β, tumor necrosis factor-α, and metalloprotein-13. Furthermore, laser irradiated animals, at 50 J/cm(2) showed a lower amount of collagen type 1.

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Section: Discussionmentioning

confidence: 69%

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

et al. 2013

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“…Renner et al (28) and Dias et al (29) studied the effects of a muscle-stretching protocol after 4 weeks of immobilization of the ankle joint. Although their analysis of cartilage thickness and the number of chondrocytes was conducted in different regions, the authors found no differences in the thickness of the articular cartilage between the groups, as in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of immobilization and remobilization on the ankle joint in Wistar rats

Kunz

Coradini

Silva

et al. 2014

Braz J Med Biol Res

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A sprained ankle is a common musculoskeletal sports injury and it is often treated by immobilization of the joint. Despite the beneficial effects of this therapeutic measure, the high prevalence of residual symptoms affects the quality of life, and remobilization of the joint can reverse this situation. The aim of this study was to analyze the effects of immobilization and remobilization on the ankle joint of Wistar rats. Eighteen male rats had their right hindlimb immobilized for 15 days, and were divided into the following groups: G1, immobilized; G2, remobilized freely for 14 days; and G3, remobilized by swimming and jumping in water for 14 days, performed on alternate days, with progression of time and a series of exercises. The contralateral limb was the control. After the experimental period, the ankle joints were processed for microscopic analysis. Histomorphometry did not show any significant differences between the control and immobilized/remobilized groups and members, in terms of number of chondrocytes and thickness of the articular cartilage of the tibia and talus. Morphological analysis of animals from G1 showed significant degenerative lesions in the talus, such as exposure of the subchondral bone, flocculation, and cracks between the anterior and mid-regions of the articular cartilage and the synovial membrane. Remobilization by therapeutic exercise in water led to recovery in the articular cartilage and synovial membrane of the ankle joint when compared with free remobilization, and it was shown to be an effective therapeutic measure in the recovery of the ankle joint.

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“…Several authors have affirmed that OA articular cartilage displays fewer organized networks and that collagen content falls in advanced OA compared to early OA articular cartilage, especially type II [21,28,[41][42][43]. In this study, the Picro-sirius polarization method was not able to show any collagen modification by comparing the results found in the intact and injured animals.…”

Section: Discussionmentioning

confidence: 47%

Effects of low-level laser therapy on cartilage repair in an experimental model of osteoarthritis

Santos

Oliveira

Fernandes

et al. 2014

Photonics &Amp; Lasers in Medicine

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Objective: The aim of this study was to evaluate the effects of low level laser therapy (LLLT) on the degenerative process in the articular cartilage after an anterior cruciate ligament transection (ACLT) model in rats. Methods: Eighty male rats (Wistar) were divided into four groups: 1.) intact control group (CG), 2.) injured control group (ICG), 3.) injured laser-treated group at 10 J/cm 2 (L10) and 4.) injured laser-treated group at 50 J/cm 2 (L50). Animals were divided into 2 subgroups, with different periods of sacrifice (5 and 8 weeks post-surgery). The ACLT was used to induce osteoarthritis (OA) in the knees of the rats. LLLT started 2 weeks after the surgery and it was performed for 15 and 30 sessions, respectively using a 685-nm laser, at 10 and 50 J/cm 2 . Qualitative and semiquantitative histologic, morphometric and immunohistochemistry analyses were performed. Results: Initial signs of tissue degradation could be observed 5 weeks post-ACLT, evidenced by the decrease of proteoglycan concentration and increase in cartilage thickness of the ICG. After 8 weeks post-surgery, analysis showed a progression of the degenerative processes in the ICG revealed by the increased cellularity and higher TNF-α, IL1-β and MMP-13 immunoexpression. LLLT was able to modulate some of the aspects relating to the degradative process, such as biomodulation of the number of chondrocyte proliferation, prevention of proteoglycan loss, and decrease of MMP-13 immunoexpression. Conclusion: This study showed that the 685-nm laser irradiation, especially at 10 J/cm 2 , prevented features related to the articular degenerative process in the knees of rats. ZusammenfassungZiel: Das Ziel dieser Studie war es, die Effekte der LowLevel-Lasertherapie (LLLT) auf den degenerativen Prozess im Gelenkknorpel von Ratten nach vorderer Kreuzbanddurchtrennung zu evaluieren. Methoden: Achtzig männliche Wistar-Ratten wurden in vier Versuchsgruppen unterteilt: 1.) intakte Kontrollgruppe (CG), 2.) verletzte Kontrollgruppe (ICG), 3.) verletzte Laser-behandelte Gruppe bei 10 J/cm 2 (L10) und 4.) verletzte Laser-behandelte Gruppe bei 50 J/cm 2 (L50). Die Tiere wurden in zwei Untergruppen aufgeteilt und entweder 5 oder 8 Wochen nach der Operation eingeschläfert. Die vordere Kreuzbanddurchtrennung wurde verwendet, um in den Kniegelenken der Ratten Osteoarthritis (OA) zu induzieren. Die LLLT begann 2 Wochen nach der Operation und wurde für 15 bzw. 30 Sitzungen bei 10 und 50 J/cm 2 mit einem 685 nm-Laser durchgeführt. Qualitative und semi-quantitative histologische, morphometrische und immunhistochemische Analysen wurden durchgeführt. Ergebnisse: Erste Anzeichen von Gewebeabbau wurden 5 Wochen nach der vorderen Kreuzbanddurchtrennung beobachtet und durch die Abnahme der ProteoglycanKonzentration und die Erhöhung der Knorpeldicke in der verletzten Kontrollgruppe (ICG) belegt. Acht Wochen nach der Operation zeigte sich in der ICG ein Fortschreiten der degenerativen Prozesse durch eine erhöhte Zellularität und eine höhere TNF-α-, IL1-β-und MMP-13-Immunexpression....

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Progression of Articular Cartilage Degeneration after Application of Muscle Stretch

Cited by 6 publications

References 36 publications

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

Effects of phototherapy on cartilage structure and inflammatory markers in an experimental model of osteoarthritis

Effects of immobilization and remobilization on the ankle joint in Wistar rats

Effects of low-level laser therapy on cartilage repair in an experimental model of osteoarthritis

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