2009
DOI: 10.1016/j.atherosclerosis.2008.11.031
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Progression of atherosclerosis in the Apo E−/− model: 12-Month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet

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Cited by 39 publications
(34 citation statements)
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“…It is a filter cigarette with reported mainstream smoke yields per cigarette of 11.0 mg total particulate matter (TPM), 0.73 mg nicotine, and 12.0 mg carbon monoxide (CO) (http://www2.ca.uky.edu/refcig/3R4F%20Preliminary%20Analysis.pdf). All cigarettes were conditioned and smoked according to International Organization for Standardization or Health Canada Intense parameters [28, 30, 31]. Mainstream CS was diluted with filtered conditioned air to a target concentration of 750 mg TPM/m 3 , unless otherwise noted (Table 1).…”
Section: Methodsmentioning
confidence: 99%
“…It is a filter cigarette with reported mainstream smoke yields per cigarette of 11.0 mg total particulate matter (TPM), 0.73 mg nicotine, and 12.0 mg carbon monoxide (CO) (http://www2.ca.uky.edu/refcig/3R4F%20Preliminary%20Analysis.pdf). All cigarettes were conditioned and smoked according to International Organization for Standardization or Health Canada Intense parameters [28, 30, 31]. Mainstream CS was diluted with filtered conditioned air to a target concentration of 750 mg TPM/m 3 , unless otherwise noted (Table 1).…”
Section: Methodsmentioning
confidence: 99%
“…Similarly, in animal models, developmental cigarette smoke exposure (CSE) induces cardiovascular disease, hypertension, and a predisposition to obesity with a high fat diet challenge [3033]. The putative link between developmental CSE and adult onset hypertension and cardiovascular disease may be attributed in part to a mild structural dysmorphology and proportionally smaller kidney size, which when coupled to obesity results in nephron hyperfiltration [3437].…”
Section: Introductionmentioning
confidence: 99%
“…It has been proposed that underlying metabolic dysfunction contributes to the propensity for adult onset disease in offspring developmentally exposed to cigarette smoke [30, 33, 4043]. In our prior study of the impact of developmental CSE on kidney proteome profiles at weaning in a murine model of 'active' exposure that spanned gestation day 1 through postnatal day 21, we identified several metabolic pathways including glucose metabolism that were altered at a time point immediately after the cessation of exposure [41].…”
Section: Introductionmentioning
confidence: 99%
“…Atherosclerosis is the main underlying cause of CVD [2], and dyslipidemia and systemic inflammation are considered to be the most important contributors to atherosclerosis development. This increased risk of COPD patients for CVD is thus independent of common risk factors, such as smoking, which can have substantial effects on atherosclerosis development by itself [3], [4]. Current therapy of COPD patients with CVD is based on lipid-lowering treatment which is added to COPD treatment with bronchodilators and anti-inflammatory drugs [5].…”
Section: Introductionmentioning
confidence: 99%