Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population

Shimizu, Yūji

doi:10.3390/life13071588

Cited by 3 publications

(2 citation statements)

References 79 publications

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“…Intensive blood pressure control is effective and safe in patients with PAD [36]. Hypertension induces thickness of the smooth muscle cell layer of the media, fibrosis, remodeling of large arteries, and arterial stiffness, contributing to PAD [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes

Bulum,

Brkljačić,

Tičinović Ivančić

et al. 2024

Biomedicines

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Type 2 diabetes mellitus (T2DM) significantly increases the risk of peripheral artery disease (PAD), and diabetes is the leading cause of nontraumatic amputations. This study investigated the risk factors for transcutaneous oxygen pressure (TcPO2) in T2DM, a noninvasive method to quantify skin oxygenation and the underlying microvascular circulation. The study included 119 T2DM patients (91 male/28 female). TcPO2 measurements were conducted with the Tina TCM4 Series transcutaneous monitor (Radiometer, Copenhagen, Sweden) and skin electrodes. Patients with TcPO2 < 40 mmHg were younger (p = 0.001), had significantly higher systolic blood pressure (SBP) (p = 0.023), glycated hemoglobin (HbA1c) (p = 0.013), fasting plasma glucose (fPG) (p = 0.038), total cholesterol (p = 0.006), LDL cholesterol (p = 0.004), and had more frequent smoking habits (p = 0.001) than those with TcPO2 ≥ 40 mmHg. The main predictors for the TcPO2 value (R2 = 0.211) obtained via stepwise regression analysis were age, smoking, SBP, HbA1c, fPG, and total and LDL cholesterol. Among all the listed predictors, smoking, HbA1c, and LDL cholesterol were found to be the most significant, with negative parameter estimates of −3.051310 (p = 0.0007), −2.032018 (p = 0.0003), and −2.560353 (p = 0.0046). The results of our study suggest that in association with other risk factors, smoking is the main predictor for lower TcPO2 in T2DM.

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Section: Discussionmentioning

confidence: 99%

In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes

Bulum,

Brkljačić,

Tičinović Ivančić

et al. 2024

Biomedicines

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“…CUSIP refers to image-based carotid artery phenotypes [ 63 , 68 , 182 , 183 ]. This training program is adaptable to non-linear adaptation [ 10 , 160 , 163 , 171 , 184 , 185 ]. Fig.…”

Section: Ultraaigenomics: -Based Deep Learning For Cvd Ri...mentioning

confidence: 99%

UltraAIGenomics: Artificial Intelligence-Based Cardiovascular Disease Risk Assessment by Fusion of Ultrasound-Based Radiomics and Genomics Features for Preventive, Personalized and Precision Medicine: A Narrative Review

Saba,

Maindarkar,

Johri

et al. 2024

Rev. Cardiovasc. Med.

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Cardiovascular disease (CVD) diagnosis and treatment are challenging since symptoms appear late in the disease’s progression. Despite clinical risk scores, cardiac event prediction is inadequate, and many at-risk patients are not adequately categorised by conventional risk factors alone. Integrating genomic-based biomarkers (GBBM), specifically those found in plasma and/or serum samples, along with novel non-invasive radiomic-based biomarkers (RBBM) such as plaque area and plaque burden can improve the overall specificity of CVD risk. This review proposes two hypotheses: (i) RBBM and GBBM biomarkers have a strong correlation and can be used to detect the severity of CVD and stroke precisely, and (ii) introduces a proposed artificial intelligence (AI)—based preventive, precision, and personalized ( ) CVD/Stroke risk model. The PRISMA search selected 246 studies for the CVD/Stroke risk. It showed that using the RBBM and GBBM biomarkers, deep learning (DL) modelscould be used for CVD/Stroke risk stratification in the framework. Furthermore, we present a concise overview of platelet function, complete blood count (CBC), and diagnostic methods. As part of the AI paradigm, we discuss explainability, pruning, bias, and benchmarking against previous studies and their potential impacts. The review proposes the integration of RBBM and GBBM, an innovative solution streamlined in the DL paradigm for predicting CVD/Stroke risk in the framework. The combination of RBBM and GBBM introduces a powerful CVD/Stroke risk assessment paradigm. model signifies a promising advancement in CVD/Stroke risk assessment.

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Association Between Asian Flush and Satisfaction of Sleep via Alcohol Consumption Status in a Sample of Japanese Participants

Shimizu,

Yoshida,

Ito

et al. 2024

Medical Sciences

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Background: The reddening of the face and neck following alcohol consumption is known as Asian flush. Although genetic factors related to Asian flush have been reported to be inversely associated with duration of sleep, no study has reported an association between Asian flush and sleep satisfaction. Methods: A cross-sectional study of 3823 Japanese people, aged 20 to 64 years was conducted. The target population comprised general public resident monitors of Osaka Prefecture who were registered with an internet research company. Results: A significant inverse association was observed between Asian flush and satisfaction of sleep. The potential confounder-adjusted odds ratio (OR) and 95% confidence interval (CI) of satisfied sleep was 0.81 (0.69–0.96). The alcohol consumption status-specific analysis revealed essentially the same associations between consumers and non-consumers of alcohol. The adjusted ORs (95% CIs) were 0.81 (0.65–0.997) for non-consumers and 0.80 (0.61–1.05) for consumers of alcohol. Conclusion: The genetic characteristics of physical reactions to alcohol exposure may influence sleep quality. One’s alcohol consumption status may not influence the effects of having a lower tolerance to alcohol on sleep quality.

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Progression of Carotid Intima-Media Thickness Partly Indicates the Prevention of Hypertension among Older Individuals in the General Population

Cited by 3 publications

References 79 publications

In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes

In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes

UltraAIGenomics: Artificial Intelligence-Based Cardiovascular Disease Risk Assessment by Fusion of Ultrasound-Based Radiomics and Genomics Features for Preventive, Personalized and Precision Medicine: A Narrative Review

Association Between Asian Flush and Satisfaction of Sleep via Alcohol Consumption Status in a Sample of Japanese Participants

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