Progression of inflammatory bowel disease in China

Wang, Yu Fang; Ouyang, Qi; Hu, Robert

doi:10.1111/j.1751-2980.2010.00421.x

Cited by 74 publications

(55 citation statements)

References 18 publications

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“…A recent report reviewed what is known about the epidemiology of IBD in China [7]. The authors reviewed the Chinese medical literature and found that in the years 1989-2003, there were reports totaling 143,511 patients with IBD, although it is uncertain if reports were mutually exclusive such that subjects would not have been counted more than once.…”

Section: Introductionmentioning

confidence: 98%

Epidemiologic Clues to Inflammatory Bowel Disease

Bernstein

2010

Curr Gastroenterol Rep

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In this article, the recent literature exploring the epidemiology of inflammatory bowel disease (IBD) is reviewed. Epidemiologic studies present data on disease burden, but may also provide clues to disease etiology. The emergence of IBD in developing nations warrants a systematic search for environmental changes in those countries to explain the evolution of IBD. The hygiene hypothesis suggests that an alteration in the microbial environment experienced by the host facilitates the evolution of chronic immune-mediated diseases. One complex database study suggested that areas with high species richness of human intestinal helminthes are areas with genetic changes in interleukin gene loci. In other words, over the years, the microbial ecology has affected human genetics, which in turn would have an impact on immune responses. Other factors affect the gut microbiome, and several studies have explored the increase in incidence of IBD in relation to such factors as exogenous infections, use of antibiotics, and diet.

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Section: Introductionmentioning

confidence: 98%

Epidemiologic Clues to Inflammatory Bowel Disease

Bernstein

2010

Curr Gastroenterol Rep

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“…This disease is chronic, incurable, and prone to relapse. As lifestyles continue to move toward a more Western style, the incidence and prevalence of CD in China have been increasing [1,2] , and as a result, this disease continues to attract the attention of researchers and clinical physicians. Approximately 75%-80% of patients require surgical resection at some point in their lives after a diagnosis of CD [3] .…”

Section: Introductionmentioning

confidence: 99%

Clinical literature review of 1858 Crohn's disease cases requiring surgery in China

Peng

Zhang

et al. 2015

WJG

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“…Reflecting this trend, in a comparative study, the UC:CD ratio was approximately 2.0 in Asia and 0.5 in Australia [1]. Various studies across Asia have shown that the UC:CD ratio is narrowing [7,8]. Although there is increased disease awareness, access to medical care and improved diagnostic tools may play a role in this epidemiological shift [9]; these factors alone are unlikely to account for the entirety of such changes.…”

Section: Epidemiologymentioning

confidence: 99%

The Same Intestinal Inflammatory Disease despite Different Genetic Risk Factors in the East and West?

Lui

2016

Inflamm Intest Dis

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Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with unknown etiology. It is likely caused by a complex interplay between genetic, immunologic and environmental factors. Although IBD is still relatively uncommon in Asia, a multitude of studies have shown that it is an emerging disease around the world. Recent insights have highlighted both the similarities and differences amongst Asian and Western IBD patients. Summary: The annual incidence of IBD in the East is still low compared with the West, but there are differences between different regions of Asia. Time trend studies have shown that the incidence of IBD is on the rise. Some notable differences in the clinical manifestations of IBD between the East and West have also been noted. ‘Westernization' of lifestyle may encompass various social and environmental changes that account for the emergence of IBD in our population, although genetics also plays a role in disease pathogenesis. Diagnosis and treatment challenges include limited access to medical care in certain areas, limited availability and high cost of medications, lack of insurance reimbursement, paucity of multidisciplinary teams for the management of complicated IBD cases, and a high prevalence of endemic infections. Currently, the risk of colorectal cancer is lower in the East than in the West, but cancer rates will likely approach that of the West in the future as the prevalence of IBD continues to rise. Key Messages: Measures to improve access to diagnostic tools, increase the availability of medication, and provide adequate multidisciplinary care for IBD patients will become increasingly important in Asia. Differences between the East and West will provide a unique opportunity for global collaboration in basic and clinical research to further our understanding of the disease entity and also provide more locoregional data to healthcare providers and policymakers to make informed decisions and policy changes when tackling the rising burden of IBD in Asia.

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Progression of inflammatory bowel disease in China

Cited by 74 publications

References 18 publications

Epidemiologic Clues to Inflammatory Bowel Disease

Epidemiologic Clues to Inflammatory Bowel Disease

Clinical literature review of 1858 Crohn's disease cases requiring surgery in China

The Same Intestinal Inflammatory Disease despite Different Genetic Risk Factors in the East and West?

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