Progression of medial compartmental osteoarthritis 2–8 years after lateral closing-wedge high tibial osteotomy

Huizinga, Maarten R.; Gorter, Jelle; Demmer, Anna; Bierma-Zeinstra, Sita M A; Brouwer, Reinoud W

doi:10.1007/s00167-016-4232-9

Cited by 29 publications

(20 citation statements)

References 56 publications

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“…In the present study, no joint space narrowing or increase in space was observed in 73% of knees, and 57% of all knees increased their minimal JSW by more than 0.5 mm. The difference with respect to our data was the small proportion of patients with a decreasing minimal JSW after HTO (27% in the current study’s knees vs 48% 13 ) (Table 2).…”

Section: Discussioncontrasting

confidence: 87%

“…Previous studies showed similar widening of the medial joint space, ranging from 0.4 mm to 1.1 mm, but did not report the serial change in the minimal JSW or the endurance of healed cartilage. 30,37 Huizinga et al 13 reported that the minimal JSW changed from 3.4 ± 1.5 mm preoperatively to 3.3 ± 1.6 mm at an average follow-up of 5.2 years. No joint space narrowing or increase in space was observed in 52% of patients, and 31% of all patients increased their minimal JSW by more than 0.5 mm.…”

Section: Discussionmentioning

confidence: 99%

“…2,22,26 The procedure is thought to allow repair of the articular surface or arrest further cartilage degeneration. 13,17,32 In contrast to the frequent application of HTO in clinical practice, the biomechanical evidence regarding cartilage quality remains largely unclear. The repaired cartilage is thought to be predominantly fibrous cartilage.…”

mentioning

confidence: 99%

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Serial Changes in the Joint Space Width and Joint Line Convergence Angle After Closed-Wedge High Tibial Osteotomy

et al. 2017

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Serial Changes in the Joint Space Width and Joint Line Convergence Angle After Closed-Wedge High Tibial Osteotomy

et al. 2017

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“…A limitation of this study was that it might be considered short-term relative to previous studies examining this patient population. [36][37][38] The planned analysis of the 24-month data will provide further knowledge regarding the safety and efficacy of this implant. Future studies will also require greater sample sizes to obtain more accurate and precise estimates of the intervention's effect.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of the Atlas Unicompartmental Knee System Load Absorber in Improving Pain Relief and Function in Patients Needing Unloading of the Medial Compartment of the Knee: 1-Year Follow-Up of a Prospective, Multicenter, Single-Arm Pilot Study (PHANTOM High Flex Trial)

Slynarski¹,

Walawski²,

Śmigıelski³

et al. 2017

Clin Med�Insights�Arthritis�Musculoskelet Disord

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In young patients with medial knee osteoarthritis (OA), surgical intervention may not be desirable due to preferences to avoid bone cutting procedures, return to high activity levels, and prolong implant survival. The Atlas Knee System was designed to fill the gap between ineffective conservative treatments and invasive surgery. This single-arm study included 26 patients, aged 25 to 65 years, who completed 12 months of follow-up. All dimensions of the Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Society Score significantly improved from baseline to 12 months. About 96.2% and 92.3% of patients experienced a ⩾20% improvement in their KOOS pain and WOMAC pain scores, respectively, at 12 months. This study highlights the potential benefit of a joint unloading device in the management of young patients with medial knee OA. The trial is still ongoing and another analysis is planned at 24 months.

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“…Radiologic outcomes were measured with Kellgren‐Lawrence (K‐L) grade , joint space width of medial and lateral compartment , and hip‐knee‐ankle (HKA) angle using simple radiograph. MRI was evaluated before injection and 3 and 6 months after injection.…”

Section: Methodsmentioning

confidence: 99%

Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

Lee

Kim

et al. 2019

Stem Cells Translational Medicine

355

368

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Mesenchymal stem cells (MSCs) have been the focus of an emerging treatment for osteoarthritis. However, few studies reported about outcomes of an intra‐articular injection of autologous adipose‐derived mesenchymal stem cells (AD‐MSCs). This study aimed to assess the efficacy and safety of a single intra‐articular injection of AD‐MSCs for patients with knee osteoarthritis. It was a prospective double‐blinded, randomized controlled, phase IIb clinical trial. AD‐MSCs were administered for 12 patients (MSC group), and the group was compared with 12 knees with injection of normal saline (control group) up to 6 months. All procedures were performed in the outpatient clinic. Primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score. Secondary outcome measure included various clinical and radiologic examination, and safety after injection. Change of cartilage defect after injection was evaluated using magnetic resonance imaging (MRI). Single injection of AD‐MSCs led to a significant improvement of the WOMAC score at 6 months. In the control group, there was no significant change in the WOMAC score at 6 months. No serious adverse events were observed in both groups during the follow‐up period. In MRI, there was no significant change of cartilage defect at 6 months in MSC group whereas the defect in the control group was increased. An intra‐articular injection of autologous AD‐MSCs provided satisfactory functional improvement and pain relief for patients with knee osteoarthritis in the outpatient setting, without causing adverse events at 6 months' follow‐up. Larger sample size and long‐term follow‐up are required. stem cells translational medicine 2019;8:504–511

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Progression of medial compartmental osteoarthritis 2–8 years after lateral closing-wedge high tibial osteotomy

Abstract: III.

Cited by 29 publications

References 56 publications

Serial Changes in the Joint Space Width and Joint Line Convergence Angle After Closed-Wedge High Tibial Osteotomy

Serial Changes in the Joint Space Width and Joint Line Convergence Angle After Closed-Wedge High Tibial Osteotomy

Feasibility of the Atlas Unicompartmental Knee System Load Absorber in Improving Pain Relief and Function in Patients Needing Unloading of the Medial Compartment of the Knee: 1-Year Follow-Up of a Prospective, Multicenter, Single-Arm Pilot Study (PHANTOM High Flex Trial)

Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

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