2016
DOI: 10.1161/jaha.116.003609
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Progression of Metabolic Syndrome Severity During the Menopausal Transition

Abstract: BackgroundAfter menopause, women exhibit a higher prevalence of the metabolic syndrome (MetS) and higher risk of cardiovascular disease. However, the timing of changes in MetS severity over the menopausal transition and whether these changes differ by racial/ethnic group remain unclear.Methods and ResultsWe assessed data from 1470 women from the Atherosclerosis Risk in Communities cohort who experienced transition in menopausal status over 10 years (visits 1–4). We used linear mixed models to evaluate changes … Show more

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Cited by 126 publications
(78 citation statements)
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“…Potential factors that may be relevant to the equalisation in incidence rates of type 2 diabetes in men and women among older adults could include the changes related to the hormonal transition that occurs during the menopause in women at 50 years of age. For example, increased visceral fat deposition among women after menopause may promote increased insulin resistance and elevated incidence of the metabolic syndrome in older women [70,71].…”
Section: Sex Differences In Type 2 Diabetes Prevalence In Midlife Andmentioning
confidence: 99%
“…Potential factors that may be relevant to the equalisation in incidence rates of type 2 diabetes in men and women among older adults could include the changes related to the hormonal transition that occurs during the menopause in women at 50 years of age. For example, increased visceral fat deposition among women after menopause may promote increased insulin resistance and elevated incidence of the metabolic syndrome in older women [70,71].…”
Section: Sex Differences In Type 2 Diabetes Prevalence In Midlife Andmentioning
confidence: 99%
“…Hormonal changes and lifestyle modifications, which are characteristic for the menopause period, often lead to various impairments of metabolic processes [1,2]. Aerobic exercises are often recommended to elderly or overweight individuals as the prevention of metabolic disturbances and functional limitations [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…The most vulnerable period of women's transitional age is premenopause, that is, the initial period of decreased ovarian function (mainly after 45 years and before menopause), which is accompanied by a critical decrease in estrogen levels. The implementation of estrogen deficiency during menopause includes an effect on the metabolism of lipoproteins, a direct effect on the biochemical processes in the vessel wall through specific estrogen receptors, as well as an indirect effect through the metabolism of glucose, insulin, homocysteine, haemostasis system (Su, et al, 2015;Gurka, et al, 2016).…”
Section: Introductionmentioning
confidence: 99%