Progression of Parkinsonian Signs in Parkinson Disease

Abstract

In this cohort, the progression of EPSs in PD occurred at a rate of 1.5% per year and at twice that rate among those who died. Bradykinesia, rigidity, and gait and balance impairment worsened at similar rates, whereas tremor did not, suggesting that tremor may be relatively independent of these other cardinal manifestations of PD.

Item Response Theory as an Efficient Tool to Describe a Heterogeneous Clinical Rating Scale in De Novo Idiopathic Parkinson’s Disease Patients

“…The choice of three latent variables corroborates the literature (9,13,14). In Parkinson disease clinical trials, the initiation time of PD medications is closely related to the rate of disease progression.…”

“…When analyzed independently, tremor items have been shown to progress more slowly than all other motor features (9,13,14). Non-motor symptoms occur a decade before the other symptoms (16).…”

Motor signs during the course of Alzheimer disease

“…13 As a perspective for our results, in a large community-dwelling cohort of Parkinson disease patients, annual increases for bradykinesia, gait/balance, and rigidity ranged from 2 to 3.1%, but tremor did not change. 28 Annual increase of the total MOSI score was 1.5% in that study as compared with 3% in the current one. However, direct comparison of these two rates is confounded by use of part of the UPDRS in our cohort, different baseline levels of MOSIs, and treatment with dopaminergic agents.…”

Thalamic Deep Brain Stimulation for Parkinson’s Disease

“…A recent PET study suggests that the metabolic pattern of tremor-dominant PD is significantly different from that of akinesia/rigidity-dominant PD (Mure et al, 2011). Patients with tremor-dominant PD exhibit better clinical prognoses and slower disease progression with less cognitive decline (Louis et al, 1999;Marras et al, 2002;Rajput et al, 2009). Using FDG-PET, Mure et al (2011) indicated that these clinical findings correlate with a slow deterioration of the metabolic pattern in patients with tremor-dominant PD.…”