Progression of Symptoms in the Early and Middle Stages of Huntington Disease

Abstract

Even though the symptoms of HD are fairly well characterized, their progression, especially in the early and middle stages, remains uncertain. Clarification of the disease progression is vital to improved understanding of the pathogenesis of HD and to the evaluation of therapeutic agents that are designed to slow the progression of disease. The results of this study assist in clarifying HD progression from early involuntary movements and emotional changes to more overt motor symptoms and difficulty with activities of daily living.

Huntington disease as a dual diagnosis disorder: Data from the national research roster for Huntington disease patients and families

“…Consistent with prior studies using the roster (Kirkwood et al, 2001) juvenile onset HD cases (<20 years of age) were excluded reducing the data base from 2556 to 2303 cases. To work with the largest amount of data, further exclusions for missing data took place on an analysis by analysis basis.…”

Video game play (Dance Dance Revolution) as a potential exercise therapy in Huntington’s disease: a controlled clinical trial

“…People with Huntington's disease develop motor symptoms that impair daily activities, increase fall risk, and lower quality of life. 1,2 Balance and gait deficits contribute to falls. 3 These deficits include greater postural sway, delayed balance reactions, slower gait, shortened stride length, widened support base, and increased stance and double support time.…”

Enfermedad de Huntington: tratamiento

“…La alteración de la marcha sería independiente de la corea ya que en numerosas ocasiones se objetiva beneficio de la corea con neurolépticos sin mostrar cambios en la marcha. En estos casos los neurolépticos asociados a terapia física en forma integrada produciría un notable beneficio 31 .…”