Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by a slow progression and caused by the inhalation of harmful particulate matter. Cigarette smoke and air pollutants are the primary contributing factors. Currently, the pathogenesis of COPD remains incompletely understood. The PI3K/Akt signaling pathway has recently emerged as a critical regulator of inflammation and oxidative stress response in COPD, playing a pivotal role in the disease’s progression and treatment. This paper reviews the association between the PI3K/Akt pathway and COPD, examines effective PI3K/Akt inhibitors and novel anti-COPD agents, aiming to identify new therapeutic targets for clinical intervention in this disease.

Protective effect of the total alkaloid extract from Bulbus Fritillariae Pallidiflorae on cigarette smoke-induced Beas-2B cell injury model and transcriptomic analysis

“…Therefore, to further investigate the effect of BFP-TA on gene expression in CSE-induced Beas-2B cells, Illumina sequencing technology was used to perform transcriptome sequencing, bioinformatic analysis, screening of DEGs, systematic analysis of the relevant biological functions and possible mechanism to search for possible target genes for the treatment of COPD. Subsequently, KEGG enrichment analysis revealed multiple pathways associated with COPD, including p53 signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, Nicotine addiction, PPAR signaling pathway, Cholesterol metabolism, etc., which was consistent with previous studies (33)(34)(35)(36)(37)(38), and could initially confirm the reliability of this study. Among the top 20 signaling pathways enriched based on key DEGs, we are most interested in the PPAR signaling pathway and the PI3K-Akt signaling pathway.…”

Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway

“…The pathway also promotes the nuclear translocation and activation of Nrf2, leading to the induction of genes encoding antioxidant enzymes and enhancing the cellular antioxidant capacity [ 43 ]. Studies have shown that modulating the PI3K/AKT pathway can attenuate oxidative stress, reduce lung tissue damage, and improve lung function in various lung injury models [ 44 , 45 ].…”

Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury

“…The PI3K-AKT-mTOR signaling network is highly conserved throughout eukaryotic evolution, and the molecular mechanism behind its function and biological role has undergone continual refinement. In addition to its involvement in the pathogenesis of secondary SCI (reviewed previously by He et al 2022 [131] and Xiao et al 2022 [132]), the aberrant PI3K-AKT-mTOR pathway is implicated in a variety of conditions, including cancer, chronic obstructive pulmonary disease, pulmonary fibrosis, cardiovascular disorders, and other neurological conditions [133][134][135][136]. PI3K-AKT-mTOR signaling is initiated upon extracellular signaling molecules binding to extracellular receptors, such as vascular endothelial growth factor receptor (VEGFR), B-cell receptor (BCR), interleukin-2 receptor (IL2R), and G protein-coupled receptors (GPCRs), which lead to PI3K activation [138][139][140].…”

“…The PI3K-AKT-mTOR signaling network is highly conserved throughout eukaryotic evolution, and the molecular mechanism behind its function and biological role has undergone continual refinement. In addition to its involvement in the pathogenesis of secondary SCI (reviewed previously by He et al 2022 [ 131 ] and Xiao et al 2022 [ 132 ]), the aberrant PI3K-AKT-mTOR pathway is implicated in a variety of conditions, including cancer, chronic obstructive pulmonary disease, pulmonary fibrosis, cardiovascular disorders, and other neurological conditions [ 133 , 134 , 135 , 136 ].…”