Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer’s disease

Jyoti, Amar; Plano, Andrea; Riedel, Gernot; Platt, Bettina

doi:10.1016/j.neurobiolaging.2015.07.001

Cited by 33 publications

(26 citation statements)

References 59 publications

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“…Brain activity patterns previously reported using ECG in AD mice had shown general abnormalities [15] together with progressive changes along aging in all spectral frequencies [37], or specifically in theta and delta bands [38]. Other reports also indicate the existence of specific changes in theta and gamma activities [39–42], or in the whole ECG pattern [43].…”

Section: Discussionmentioning

confidence: 99%

Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

et al. 2017

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Age is the main risk factor for Alzheimer´s disease (AD). With an increasingly aging population, development of affordable screening techniques to determine cognitive status will help identify population-at-risk for further follow-up. Because physical exercise is known to modulate cognitive performance, we used it as a functional test of cognitive health. Mice were submitted to treadmill running at moderate speed for 30 min, and their brain activity was monitored before and after exercise using electrocorticogram (ECG) recordings. After exercise, normal, but not APP/PS1 mice, a well established AD model, showed significantly increased ECG theta rhythm. At the same time normal, but not AD mice, showed significantly enhanced performance in a spatial memory test after exercise. Therefore, we postulate that a running bout coupled to pre- and post-exercise brain activity recordings will help identify individuals with cognitive alterations, by determining the presence or absence of exercise-specific changes in brain activity. Work in humans using a bout of moderate exercise plus electroencephalography, a clinically affordable procedure, is warranted.

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Section: Discussionmentioning

confidence: 99%

Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

et al. 2017

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“…Sleep disturbances have been identified in mice expressing both tau and amyloid pathology as well as mice expressing tau pathology alone in the forebrain . Furthermore, tau knockout mice have decreased sleep suggesting that loss of endogenous tau function may also contribute to sleep disturbances .…”

Section: Introductionmentioning

confidence: 99%

Altered sleep and EEG power in the P301S Tau transgenic mouse model

Holth

Mahan

Robinson

et al. 2017

Ann Clin Transl Neurol

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ObjectiveSleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology. Here, we investigate this interaction by analyzing sleep and tau pathology throughout tauopathy disease progression in P301S human tau transgenic mice.MethodsP301S and wild‐type mice were analyzed by electroencephalography (EEG)/electromyography at 3, 6, 9, and 11 months of age for sleep/wake time, EEG power, and homeostatic response. Cortical volume and tau pathology was also assessed by anti‐phospho‐tau AT8 staining.ResultsP301S tau mice had significantly decreased rapid eye movement (REM) sleep at 9 months of age and decreased REM and non‐REM (NREM) sleep as well as increased wakefulness at 11 months. Sleep loss was characterized by fewer wake, REM, and NREM bouts, increased wake bout duration, and decreased sleep bout duration. Decreased REM and NREM sleep was associated with increased brainstem tau pathology in the sublaterodorsal area and parafacial zone, respectively. P301S mice also showed increased EEG power at 6 and 9 months of age and decreased power at 11 months. Decreased EEG power was associated with decreased cortical volume. Despite sleep disturbances, P301S mice maintained homeostatic response to sleep deprivation.InterpretationOur results indicate that tau pathology is associated with sleep disturbances that worsen with age and these changes may be related to tau pathology in brainstem sleep regulating regions as well as neurodegeneration. Tau‐induced sleep changes could affect disease progression and be a marker for therapeutic efficacy in this and other tauopathy models.

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“…The ability to record EEG in mice has led to significant research findings, including age-related sleep disturbances and changes in EEG profile (Jyoti et al, 2015 ) and the presence of seizure activity in mouse models of Alzheimer's Disease (AD) (Palop et al, 2007 ), a condition previously not often recognized in AD patients due to their cognitive deficits (Vossel et al, 2013 ). Just a few years ago, EEG studies of AD patients focused on sleep abnormalities (Jeong, 2004 ), altered regional connectivity, and rhythms (Knyazeva et al, 2013 ), while more recent research is also utilizing mouse models of AD to discover the underlying causes of seizure activity in AD pathology and investigate therapeutic treatments (Sanchez et al, 2012 ; DeVos et al, 2013 ; Bomben et al, 2014 ; Born et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Low Cost Electrode Assembly for EEG Recordings in Mice

et al. 2017

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Wireless electroencephalography (EEG) of small animal subjects typically utilizes miniaturized EEG devices which require a robust recording and electrode assembly that remains in place while also being well-tolerated by the animal so as not to impair the ability of the animal to perform normal living activities or experimental tasks. We developed simple and fast electrode assembly and method of electrode implantation using electrode wires and wire-wrap technology that provides both higher survival and success rates in obtaining recordings from the electrodes than methods using screws as electrodes. The new wire method results in a 51% improvement in the number of electrodes that successfully record EEG signal. Also, the electrode assembly remains affixed and provides EEG signal for at least a month after implantation. Screws often serve as recording electrodes, which require either drilling holes into the skull to insert screws or affixing screws to the surface of the skull with adhesive. Drilling holes large enough to insert screws can be invasive and damaging to brain tissue, using adhesives may interfere with conductance and result in a poor signal, and soldering screws to wire leads results in fragile connections. The methods presented in this article provide a robust implant that is minimally invasive and has a significantly higher success rate of electrode implantation. In addition, the implant remains affixed and produces good recordings for over a month, while using economical, easily obtained materials and skills readily available in most animal research laboratories.

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Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer’s disease

Cited by 33 publications

References 59 publications

Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

Altered sleep and EEG power in the P301S Tau transgenic mouse model

Low Cost Electrode Assembly for EEG Recordings in Mice

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