Progressive and disseminated histoplasma infection and hemophagocytic lymphohistiocytosis in an immunocompetent adult

Abstract

Key Clinical Message Hemophagocytic lymphohistiocytosis (HLH) in adults is a life‐threatening underdiagnosed disorder that complicates different infectious syndromes and overlaps with sepsis. No guidelines are available for the management of HLH in adults. A high index of suspicion is required in patients with disseminated histoplasmosis.

Haemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an immunocompetent patient

“…Histoplasmosis is the most common fungal infection associated with HLH [ 2 ], primarily occurring in patients with HIV, but has been reported with solid organ transplantation, haematological malignancy and other immunosuppressed states [ 4 , 8 ]. Histoplasmosis causing HLH is rare in immunocompetent patients with only 11 other cases published [ [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ].…”