Progressive and regressive infection with feline leukemia virus (FeLV) in cats in southern Brazil: Prevalence, risk factors associated, clinical and hematologic alterations

Biezus, Giovana; Cristo, Thierry Grima de; Casa, Mariana da Silva; Lovatel, Mariângela; Vavassori, M.; Teixeira, Marcela Brüggemann de Souza; Miletti, Luiz Cláudio; Costa, Ubirajara Maciel da; Casagrande, Renata Assis

doi:10.1016/j.prevetmed.2023.105945

Cited by 3 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result should be interpreted cautiously as there was a zero cell. Nonetheless, a male predisposition for progressive FeLV infection is consistent with the findings of others, including a recent study from Brazil, which is the only other study in South America to investigate progressive FeLV infection [ 16 ], and others [ 39 ]. Of the 8/120 progressively infected cats (6.6%), most or all are expected to develop FeLV-related diseases.…”

Section: Discussionsupporting

confidence: 88%

“…Since the discovery of FeLV almost 60 years ago, changes in cat management, the identification of persistently infected cats (which shed virus), and the availability of effective FeLV vaccines have seen the prevalence of infection decline in many areas [ 14 ]. However, in other regions, including southern Italy and Brazil, progressive FeLV infection and associated disease remains common [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Domestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile

Choi,

Iturriaga,

Nekouei

et al. 2023

Viruses

View full text Add to dashboard Cite

Cat ownership is common in Chile, but data on the regional prevalence of infectious agents are limited. A sero-molecular survey of 120 client- or shelter-owned domestic cats in greater Santiago was performed. Whole blood DNA was tested for the novel hepatitis-B-like virus, domestic cat hepadnavirus (DCH) by conventional PCR (cPCR) and quantitative PCR (qPCR), and for feline leukaemia virus (FeLV) by qPCR. Point-of-care serology for FeLV p27 antigen and antibodies recognising feline immunodeficiency virus (FIV) p15 and p24 was performed. DCH DNA was detected in the serum of 2/120 cats (1.67%). Sequencing and phylogenetic analysis showed that the DCH detected in Chile occupies a position outside the main clustering of DCH in the near-complete genome tree. Progressive (antigen-positive, provirus-positive) and regressive (antigen-negative, provirus-positive) FeLV infections were identified in 6/120 (5%) and 9/120 (7.5%) of cats. A total of 2/120 (1.7%) cats had dual FeLV/FIV infection, and another 2 cats had FIV infection alone. This study shows that the global footprint of DCH includes South America with a low molecular frequency in Chile, similar to that reported in the USA. Progressive FeLV infection is relatively common in urban Chile, and male cats are at greater risk than females. Testing and control measures for pathogenic retroviruses are indicated. The potential impact of FeLV, FIV and DCH on Chile’s wildcat species is worthy of further investigation.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Domestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile

Choi,

Iturriaga,

Nekouei

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Given that animals may not respond or become resistant to standard therapy, some factors are also associated with a poorer response to treatment, and feline leukemia virus (FeLV) infection is an important factor to be considered [41]. FeLV can further worsen the quality of life for the patient, as the animal may present various clinical signs resulting from the infection, such as non-regenerative anemia, leukopenia, and thrombocytopenia [42]. Therefore, in addition to the deterioration of the patient's overall condition, they also become more susceptible to secondary infections due to immunodeficiency resulting from chemotherapy and FeLV.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells

Alves,

Xavier,

Garnica

et al. 2024

Preprint

View full text Add to dashboard Cite

Lymphoma is the most prevalent type of cancer in cats, and the search for alternative treatments is of utmost importance given the significant number of animals that exhibit tumor recurrence or are unresponsive to conventional chemotherapy treatment. Oncolytic viruses possess a unique ability to target and eliminate cancer cells while simultaneously stimulating an immune response against these malignant cells. The present study aimed to explore the oncolytic potential of Newcastle Disease Virus expressing green fluorescent protein (NDV-GFP) in a feline leukemia virus (FeLV)-positive lymphoma cell line. Our research suggests that NDV-GFP has a propensity to selectively target, infiltrate, and replicate with-in feline lymphoma cells, resulting in the induction of apoptosis in these cells, as opposed to non-tumor cells. Therefore, our research provides evidence supporting the development of novel oncolytic therapies based on NDV for the treatment of feline lymphomas.

show abstract

Neoplastic and non-neoplastic diseases associated with feline leukaemia virus (FeLV) in cats in southern Brazil

Pandolfo,

de Cristo,

Withoeft

et al. 2024

Comparative Immunology, Microbiology and Infectious Diseases

View full text Add to dashboard Cite

Progressive and regressive infection with feline leukemia virus (FeLV) in cats in southern Brazil: Prevalence, risk factors associated, clinical and hematologic alterations

Cited by 3 publications

References 48 publications

Domestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile

Domestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile

Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells

Neoplastic and non-neoplastic diseases associated with feline leukaemia virus (FeLV) in cats in southern Brazil

Contact Info

Product

Resources

About