2023
DOI: 10.1002/mds.29671
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Progressive Cerebrovascular Reactivity Reduction Occurs in Parkinson's Disease: A Longitudinal Study

Jian Wang,
Hongwei Li,
Jia Jia
et al.

Abstract: BackgroundThe change of microvascular function over the course of Parkinson's disease (PD) remains unclear.ObjectiveWe aimed to ascertain regional cerebrovascular reactivity (CVR) changes in the patients with PD at baseline (V0) and during a 2‐year follow‐up period (V1). We further investigated whether alterations in CVR were linked to cognitive decline and brain functional connectivity (FC).MethodsWe recruited 90 PD patients and 51 matched healthy controls (HCs). PD patients underwent clinical evaluations, ne… Show more

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