Progressive decline of decision-making performances during multiple sclerosis

Simioni, Samanta; Ruffieux, Christiane; Kleeberg, Joerg; Bruggimann, Laure; Pasquier, Renaud Du; Annoni, Jean‐Marie; Schluep, Myriam

doi:10.1017/s1355617709090262

Cited by 28 publications

(35 citation statements)

References 12 publications

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“…The proportion of progressive MS forms in the present study was also very low (9/84, 10.7%). A decline in decision-making process early in the disease was also noted in 11 but in this study, authors could not relate the dysfunction in the decision-making process to executive or other cognitive impairments.…”

Section: Discussionmentioning

confidence: 60%

Impairment of decision-making in multiple sclerosis: A neuroeconomic approach

et al. 2016

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Objective To assess the decision-making impairment in patients with multiple sclerosis (MS) and how they relate to other cognitive domains. Methods We performed a crossectional analysis in 84 patients with MS and 21 matched healthy controls using four tasks taken from behavioral economics: 1) risk preferences, 2) choice consistency, 3) delay of gratification, and 4) rate of learning. All tasks were conducted using real-world reward outcomes (food or money) in different real-life conditions. Participants underwent cognitive examination using the Brief Repeatable Battery-Neuropsychology. Results Patients showed higher risk aversion (general propensity to choose the lottery was 0.51 vs 0.64, p=0.009), a trend to choose more immediate rewards over larger but delayed rewards (p=0.108) and had longer reactions times (p=0.033). Choice consistency and learning rates were not different between groups. Progressive patients chose slower than relapsing patients. In relation to general cognitive impairments, we found correlations between impaired decision-making and impaired verbal memory (r= 0.29, p=0.009), visual memory (r=-0.37, p=0.001) and reduced processing speed (r=-0.32, p=0.001). Normalized grey matter volume correlated with deliberation time (r=-0.32, p=0.005). Conclusion Patients with MS suffer significant decision-making impairments, even at the early stages of the disease, and may affect patients' quality and social life.

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Section: Discussionmentioning

confidence: 60%

Impairment of decision-making in multiple sclerosis: A neuroeconomic approach

et al. 2016

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“…Little is known about the natural history of DM disturbances in MS; as mentioned, the study population comprised mostly recently diagnosed patients with MS. One longitudinal study reassessing IGT scores at 2-year intervals showed that DM deficits could progress over time 27. Interestingly, IGT performance in primary progressive MS (PPMS) seems to be significantly affected compared to HC and secondary progressive MS (SPMS),38 highlighting the heterogeneous nature of DM impairments.…”

Section: Discussionmentioning

confidence: 99%

“…In the latter, several studies have reported impaired DM under ambiguous conditions even in the absence of major mood, cognitive or physical impairment. Moreover, Simioni and colleagues showed that a decline in DM capacity under ambiguity can appear as an early deficit in patients with MS, and when retested after 2 years, individuals can show significant deterioration in IGT scores independently of other markers of cognitive, emotional or disability worsening 27. The study by Nagy and colleagues also reports that DM impairment in patients with MS can appear as an isolated deficit without the presence of generalised cognitive impairment and that this deficit is unrelated to executive function, as they did not detect a significant correlation between IGT scores and the Wisconsin Card Sorting Test 25…”

Section: Introductionmentioning

confidence: 99%

Decision-making impairment in patients with multiple sclerosis: a case–control study

et al. 2014

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ObjectivesTo assess decision-making under explicit risk conditions in relapsing–remitting multiple sclerosis patients and its relationship to decisions made under conditions of ambiguity. To assess cognitive functions related to decision-making performance in patients with multiple sclerosis (MS).SettingMS center in Buenos Aires, Argentina.Participants27 patients with relapsing–remitting multiple sclerosis and 27 sex-matched, age-matched and education-matched healthy controls.InterventionNeuropsychological assessment and decision-making evaluation using the Game of Dice Task and the Iowa Gambling Task.OutcomesGame of Dice Task and the Iowa Gambling Task scores.ResultsPatients with MS showed significantly poorer performance on the Game of Dice Task, choosing disadvantageous dice more often (p=0.019), as well as significantly lower overall scores in the Iowa Gambling Task (p=0.007). Block analysis showed that patients with MS and controls had scores that were comparable for blocks 1 and 2 (p=0.15 and p=0.24, respectively). Conversely, patients with MS scored poorly on blocks 4 (p=0.003) and 5 (p=0.023), the last two of the test, corresponding to decision-making under conditions of risk. Finally, the Game of Dice Task performance together with the last three blocks of the Iowa Gambling Task were correlated with visuospatial learning, processing speed and working memory but not with executive functioning.ConclusionsPatients with MS showed deficits in decision-making under risk conditions, which might be related to deficits in visuospatial learning, processing speed and working memory.

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“…Decision making was assessed using the Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994), which measures reward-based learning and decision making based on evaluation of long-term outcomes. PwMS have displayed impaired decision-making ability using the IGT (Kleeberg et al, 2004;Simioni et al, 2009). …”

Section: Cognition/executive Functionmentioning

confidence: 99%

The effect of executive function on stress, depression, anxiety, and quality of life in multiple sclerosis

Grech

Kiropoulos

Kirby

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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The experience of cognitive deficits and emotional dysfunction are prevalent in people with multiple sclerosis (PwMS), although research examining their interaction has provided inconsistent findings. The current study examined the ability of executive function to predict psychosocial adjustment in PwMS. One hundred and seven PwMS underwent cognitive assessment and completed measures of stress, depression, anxiety, and quality of life (QoL). There was limited support for a relationship. There was no relationship between objective cognitive tasks and state or trait anxiety, mental health QoL, overall QoL, or stress frequency. The only relationship with depression was found when the Beck Depression Inventory Fast-Screen was used, with a task of planning when the timing element was removed. A measure of error rates on a task of cognitive flexibility predicted physical health QoL, and severity, but not frequency, of stress was predicted by a task of working memory. The results of this study highlight the need for further research into the relationship between cognitive deficits and psychosocial adjustment because of the conflicting findings between studies and call for a common measurement framework for future investigation.

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Progressive decline of decision-making performances during multiple sclerosis

Cited by 28 publications

References 12 publications

Impairment of decision-making in multiple sclerosis: A neuroeconomic approach

Impairment of decision-making in multiple sclerosis: A neuroeconomic approach

Decision-making impairment in patients with multiple sclerosis: a case–control study

The effect of executive function on stress, depression, anxiety, and quality of life in multiple sclerosis

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