Progressive decrease of CD8high+ CD28+ CD57− cells with ageing

Merino, Juana; Martínez-González, M Á; Rubio, M.; Inogés, Susana; Sánchez-Ibarrola, A; Subirá, M L

doi:10.1046/j.1365-2249.1998.00551.x

Cited by 98 publications

(69 citation statements)

References 21 publications

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“…Unlike previous reports, we found no correlation with age in this cohort, but this may be due to the relatively greater age of this patient population compared with previous reports. 34 Importantly, we found no effect of drug regimen on the number of CD8 ϩ CD28…”

Section: Cd28mentioning

confidence: 66%

“…Regarding CD8 ϩ CD28 Ϫ T cells, it is known that increasing age, 34 chronic viral infections such as cytomegalovirus (CMV), 35 and cancer status 20,36 can increase the number of these cells. Although age was not an independent predictor of CD8 Figure 1), so although KTRs with SCC had poorer proliferative responses compared with KTRs without SCC (Figure 1), part of this observation was explained by CD8…”

Section: Resultsmentioning

confidence: 99%

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Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Carroll

Segundo²,

Hollowood³

et al. 2010

Journal of the American Society of Nephrology

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Cutaneous squamous cell cancer (SCC) affects up to 30% of kidney transplant recipients (KTRs) within 10 years of transplantation. There are no reliable clinical tests that predict those who will develop multiple skin cancers. High numbers of regulatory T cells associate with poor prognosis for patients with cancer in the general population, suggesting their potential as a predictive marker of cutaneous SCC in KTRs. We matched KTRs with (n ϭ 65) and without (n ϭ 51) cutaneous SCC for gender, age, and duration of immunosuppression and assessed several risk factors for incident SCC during a median follow-up of 340 days. Greater than 35 peripheral FOXP3 ϩ CD4 ϩ CD127 low regulatory T cells/l, Ͻ100 natural killer cells/l, and previous SCC each significantly associated with increased risk for new cutaneous SCC development (hazard ratio [HR] 2.48 [95% confidence interval (CI) 1.04 to 5.98], HR 5.6 [95% CI 1.31 to 24], and HR 1.33 [95% CI 1.15 to 1.53], respectively). In addition, the ratio of CD8/FOXP3 expression was significantly lower in cutaneous SCC excised from KTRs (n ϭ 25) compared with matched SCC from non-KTRs (n ϭ 25) and associated with development of new cutaneous SCCs. In summary, monitoring components of the immune system can predict development of cutaneous SCC among KTRs.

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Section: Cd28mentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Carroll

Segundo²,

Hollowood³

et al. 2010

Journal of the American Society of Nephrology

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“…27,28 In addition, loss of CD28 expression is known to be associated with the expression of CD57, a terminally sulfated glycoprotein. 29,30 Therefore, both the CD28 null and CD57 1 phenotypes of T cells have been considered markers of immunosenescence. 15 In fact, CD8 1 CD28 null T cells overlapped significantly with the CD8 1 CD57 1 T-cell population in our study ( Figure 1f); however, the short-term cardiovascular mortality of acute MI patients was independently associated with only the frequency of CD8 1 CD57 1 cells (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Youn

Lee

et al. 2014

Cell Mol Immunol

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Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studied the immunological characteristics and clinical impact of CD8 1 CD57 1 T cells in acute MI patients. The frequency of CD57 1 cells among CD8 1 T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57 1 cells in the CD8 1 T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8 1 CD57 1 T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8 1 CD57 1 T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8 1 CD57 1 T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8 1 T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8 1 T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

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“…CD57 has also been associated with a history of a greater number of cell divisions and short telomeres, markers of senescence (11). CD57 expression is increased in NK cells of patients with HIV infection, probably as a result of chronic antigenic stimulation, and in other conditions associated with immune activation, as well as with increasing age (11)(12)(13)(14)(15). How CD57 and KLRG1 interrelate and whether the profiles of expression of different combinations of these markers could offer a more precise functional delineation of these cellular subtypes has not been studied to date.…”

Section: Cd4mentioning

confidence: 99%

Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57

Ibegbu

Xu²,

Harris³

et al. 2005

The Journal of Immunology

158

115

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Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like receptors expressed by NK cells and T lymphocytes, mainly CD8+ effector/memory cells that can secrete cytokines but have poor proliferative capacity. Using multiparameter flow cytometry, we studied KLRG1 expression on CD8+ T cells specific for epitopes of CMV, EBV, influenza, and HIV. Over 92% of CD8+ cells specific for CMV or EBV expressed KLRG1 during the latent stage of these chronic infections. CD8+ T cell cells specific for HIV epitopes were mostly (72–89%) KLRG1+, even though not quite at the level of predominance noted with CMV or EBV. Lower frequency of KLRG1 expression was observed among CD8+ cells specific for influenza (40–73%), a resolved infection without a latent stage. We further observed that CD8+ cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57−KLRG1+ cells was also identified. This population may represent a “memory” phenotype, because they also expressed CD27, CD28, CCR7, and CD127. In contrast, CD57+KLRG1+ cells did not express CD27, CD28, and CCR7, and expressed CD127 at a much lower frequency, indicating that they represent effector cells that are truly terminally differentiated. The combination of KLRG1 and CD57 expression might thus aid in refining functional characterization of CD8+ T cell subsets.

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Progressive decrease of CD8high+ CD28+ CD57− cells with ageing

Cited by 98 publications

References 21 publications

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57

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