2012
DOI: 10.1038/tp.2012.116
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Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies

Abstract: Cortical gray matter deficits have been found in patients with schizophrenia, with evidence of progression over time. The aim of this study was to determine the extent of progressive cortical gray matter volume changes over time in schizophrenia, their site and time of occurrence, and the role of potential moderators of brain changes. English language articles published between 1 January 1983 and 31 March 2012 in the MEDLINE and EMBASE databases were searched. Longitudinal magnetic resonance imaging studies co… Show more

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Cited by 385 publications
(332 citation statements)
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References 110 publications
(165 reference statements)
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“…We excluded current drug or alcohol abuse, but data on substance abuse in the past were not systematically collected and could have differed between groups. Finally and in common with other neuroimaging studies of psychosis, the patients were medicated, which both in the case of antipsychotics 54, 55 and lithium 56 has the potential to influence brain volume 23.…”
Section: Discussionmentioning
confidence: 99%
“…We excluded current drug or alcohol abuse, but data on substance abuse in the past were not systematically collected and could have differed between groups. Finally and in common with other neuroimaging studies of psychosis, the patients were medicated, which both in the case of antipsychotics 54, 55 and lithium 56 has the potential to influence brain volume 23.…”
Section: Discussionmentioning
confidence: 99%
“…17,18 These grey matter deficits are present even in the early stages of illness (i.e., immediately after the onset), 19,20 and to some extent are shared by healthy siblings who carry the genetic risk. 6,21,22 These grey matter deficits appear to intensify following the onset, 23,24 especially in the first few years, 25 but generally slow down with time, irrespective of clinical status. 26 In this context, it is not surprising that Dukart and colleagues' results appear as an outlier.…”
Section: The Issue Of Grey Matter Excess In Psychosismentioning
confidence: 99%
“…increasing ventricular volume and loss of gray matter) in chronic and FE schizophrenia and in UHR patients who develop psychosis at follow-up (Lieberman et al 2001;Pantelis et al 2003;Olabi et al 2011;Vita et al 2012;Fusar-Poli et al 2013b). However, a more important question is whether these changes are related to the progressive pathology of schizophrenia or reflections of other factors.…”
Section: Illusion Of Progression In Schizophreniamentioning
confidence: 99%