Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes

Litjens, Nicolle H.R.; Druningen, Corné J. van; Betjes, Michiel G. H.

doi:10.1016/j.clim.2005.09.007

Cited by 134 publications

(175 citation statements)

References 37 publications

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“…+ central memory population [31]. There are some possible explanations for lymphocyte depletion in CKD patients, namely, increased turnover, disturbance of lymphocyte homeostasis due to uremia and increased peripheral lymphocyte apoptosis associated with activation stimulus [14,[31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

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Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

et al. 2008

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Background Resistance to recombinant human erythropoietin (rhEPO) occurs in some chronic kidney disease (CKD) patients, which may be due to enhanced systemic inflammatory response and to the erythropoiesis-suppressing effect of pro-inflammatory cytokines, some of which are produced by T cells. Aim of study The aim of this study was to investigate the relationship between resistance to rhEPO therapy in hemodialysis CKD patients and inflammatory markers [Creactive protein (CRP), soluble interleukin (IL)-2 receptor (sIL2R), and serum albumin levels], blood cell counts, Tcell phenotype, cytokine production by T cells, and serum cytokine levels. Materials and Methods We studied 50 hemodialysis CKD patients, 25 responders and 25 nonresponders to rhEPO, and compared them to each other and with 25 healthy controls. When compared to controls, CKD patients showed increased serum levels of CRP, IL-6, and sIL2R and a T-cell lymphopenia, due to decreased numbers of both CD4 + and CD8 + T cells. T cells from CKD patients had an immunophenotype compatible with chronic T-cell stimulation as shown by the increased percentage of CD28

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Section: Discussionmentioning

confidence: 99%

“…The mechanism responsible for this immune defect is still unknown. However, it is known that lymphopenia is associated to end-renal failure, occurring in the B-and T-lymphocyte compartment, probably due to increased apoptosis [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

et al. 2008

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“…Enriched T lymphocytes were prepared for sorting experiments using the following mAbs: AmCyanlabeled CD3 (BD Pharmingen, Erembodegem, Belgium), Pacific Bluelabeled CD4 (BD Pharmingen), PeCy7-labeled CD25 (epitope A; BD Pharmingen), PE-labeled CD127 (BD Pharmingen), and inclusion of a live/ dead marker ViaProbe (7- 2 ) T cells (17), using allophycocyaninlabeled CD45RO (BD Pharmingen) and FITC-labeled CCR7 (R&D Systems Europe, Abingdon, U.K.).…”

Section: Cell Sorting Experimentsmentioning

confidence: 99%

Identification of Circulating Human Antigen-Reactive CD4+FOXP3+ Natural Regulatory T Cells

Litjens

Boer

Betjes

2012

The Journal of Immunology

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Circulating human CD4+CD25++CD127−FOXP3+ T cells with a persistent demethylated regulatory T cell (Treg)-specific demethylated region Foxp3 gene are considered natural Tregs (nTregs). We have shown that it is possible to identify functional Ag-reactive nTregs cells for a range of different common viral and vaccination Ags. The frequency of these Ag-reactive nTregs within the nTreg population is strikingly similar to the frequency of Ag-reactive T effector cells within the CD4+ T cell population. The Ag-reactive nTregs could be recognized with great specificity by induction of CD154 expression. These CD154+ Ag-reactive nTregs showed a memory phenotype and shared all phenotypical and functional characteristics of nTregs. The isolated CD154+ nTregs could be most efficiently expanded by specific antigenic stimulation, while their Ag-reactive suppressive activity was maintained. After an in vivo booster Ag challenge, the ratio of Ag-reactive T cells to Ag-reactive Tregs increased substantially, which could be attributed to the rise in effector T cells but not Tregs. In conclusion, the nTreg population mirrors the effector T cell population in the frequency of Ag-reactive T cells. Isolation and expansion of functional Ag-reactive nTregs is possible and of potential benefit for specific therapeutic goals.

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“…The study by Litjens et al 31 showed that already in moderate CKD (GFR between 30 and 59 ml/min/1.73 m 2 ), the lymphocyte compartment was decreased in relation to a further loss of renal function. The inverse association between CCL23 levels and the percentage of lymphocytes observed in this study is difficult to explain at present.…”

mentioning

confidence: 99%

Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease

Pawlak¹,

Myśliwiec²,

Pawlak³

2014

Polish Archives of Internal Medicine

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Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes

Cited by 134 publications

References 37 publications

Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

Identification of Circulating Human Antigen-Reactive CD4+FOXP3+ Natural Regulatory T Cells

Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease

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