Progressive Magnesium Deficiency Increases Mortality From Endotoxin Challenge: Protective Effects of Acute Magnesium Replacement Therapy

Salem, Michael; Kasinski, Nelson; Muñoz, Ricardo; Chernow, Bart

doi:10.1097/00003246-199501001-00459

Cited by 19 publications

(26 citation statements)

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“…22 In animal models, magnesium deficiency increases the production of inflammatory cytokines with increase in lethality associated with endotoxin challenge. 23,24 Showed that progressive magnesium deficiency and hypomagnesemia are strongly associated with increased mortality in experimental sepsis and magnesium replacement therapy provides significant protection from an endotoxin challenge.…”

Section: Discussionmentioning

confidence: 99%

Hypomagnesemia is associated with increase in mortality and morbidity in ICU: Can serum magnesium level be used as prognostic marker in critically ill ICU admitted patients?

Islam¹,

Faruq

Asaduzzaman

et al. 2017

Bangladesh Crit Care J

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high (33.3% vs 11.86%, p<0.01). Conclusion: In this study it was observed that Hypomagnesemia was significantly associated with adverse outcome. So it is better not to ignore this important confounder to predict the outcome of the critically ill ICU admitted patient.Considering the increasing demand of more accurate prognostic marker in critically ill patient, it maybe the high time to utilize serum Mg level systematically for outcome prediction.

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Section: Discussionmentioning

confidence: 99%

Hypomagnesemia is associated with increase in mortality and morbidity in ICU: Can serum magnesium level be used as prognostic marker in critically ill ICU admitted patients?

Islam¹,

Faruq

Asaduzzaman

et al. 2017

Bangladesh Crit Care J

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show abstract

“…As previously stated, sepsis was the leading cause of AKI in our study population. Salem et al (37) showed that progressive magnesium deficiency and hypomagnesemia are strongly associated with increased mortality in experimental sepsis. In patients with sepsis or septic shock, the prevalence of hypomagnesemia is high, and sepsis has been identified as an independent risk factor for developing hypomagnesemia during an ICU stay (35).…”

Section: Discussionmentioning

confidence: 99%

Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality in AIDS patients with acute kidney injury

Santos

Seguro

Andrade

2010

Braz J Med Biol Res

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5 years, 72% had CD4 counts <200 cells/mm³, 87% developed electrolyte disturbances, 33% recovered renal function, and 56% survived. ICU admission, dialysis, sepsis and hypomagnesemia were all significantly associated with nonrecovery of renal function and with mortality. Nonrecovery of renal function was significantly associated with hypomagnesemia, as was mortality in the multivariate analysis. The risks for nonrecovery of renal function and for death were 6.94 and 6.92 times greater, respectively, for patients with hypomagnesemia. In hospitalized AIDS patients, hypomagnesemia is a risk factor for nonrecovery of renal function and for in-hospital mortality. To determine whether hypomagnesemia is a determinant or simply a marker of critical illness, further studies involving magnesium supplementation in AIDS patients are warranted.]]>

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“…Magnesium may play an important role in sepsis, as magnesium ions are essential for several important immunologic functions and serve as a natural calcium antagonist, an important step in propagating cellular injury (36,37). In animal models, magnesium deficiency increased production of inflammatory cytokines with increases in lethality associated with endotoxin challenge (38 -41).…”

Section: Discussionmentioning

confidence: 99%

Development of ionized hypomagnesemia is associated with higher mortality rates

Soliman

Mercan²,

Lobo³

et al. 2003

Critical Care Medicine

171

121

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Progressive Magnesium Deficiency Increases Mortality From Endotoxin Challenge: Protective Effects of Acute Magnesium Replacement Therapy

Cited by 19 publications

References 0 publications

Hypomagnesemia is associated with increase in mortality and morbidity in ICU: Can serum magnesium level be used as prognostic marker in critically ill ICU admitted patients?

Hypomagnesemia is associated with increase in mortality and morbidity in ICU: Can serum magnesium level be used as prognostic marker in critically ill ICU admitted patients?

Hypomagnesemia is a risk factor for nonrecovery of renal function and mortality in AIDS patients with acute kidney injury

Development of ionized hypomagnesemia is associated with higher mortality rates

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