Progressive multifocal leukoencephalopathy with natalizumab extended or standard interval dosing in the United States and the rest of the world

D’silva, Liesel; McCarthy, Kerry; Lyons, Jennifer L.; Cabigas, Bernadette; Campbell, Nolan; Kong, George; Adams, Bryan; Kuhelj, Robert; Singhal, Priya; Smirnakis, Karen

doi:10.1080/14740338.2023.2221027

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…The presence of JCV DNA in the cerebrospinal fluid (CSF) of people with MS has been detected in some patients treated with natalizumab. However, the presence of JCV DNA does not necessarily mean that the patient will develop PML [102].…”

Section: N Immunomodulatory Therapies and Their Potential Effect On M...mentioning

confidence: 99%

Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis

2023

Infez Med

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). The underlying cause of MS is still unknown. Multiple risk factors have been suggested that involve a combination of genetic, environmental, and infectious factors that contribute along with a weakened immune system. There is growing evidence supporting the potential role of viral infections in the development of the disease. Viruses like human immunodeficiency virus (HIV), John Cunningham virus (JCV), Varicella-Zoster virus (VZV), human herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), and human endogenous retroviruses (HERVs) have been proposed in the pathogenesis of MS. Their pathogenetic mechanisms are not well known, but several possibilities have been discussed. The present study highlights the proposed potential molecular and genetic mechanisms underlying this viral interaction and its implications for the development of MS.

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Section: N Immunomodulatory Therapies and Their Potential Effect On M...mentioning

confidence: 99%

Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis

2023

Infez Med

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Revisiting JC virus and progressive multifocal leukoencephalopathy

Rocchi,

Sariyer,

Berger

2023

J. Neurovirol.

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Routine MR Imaging Protocol and Standardization in Central Nervous System Demyelinating Diseases

Traboulsee,

2024

Neuroimaging Clinics of North America

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Progressive multifocal leukoencephalopathy with natalizumab extended or standard interval dosing in the United States and the rest of the world

Cited by 4 publications

References 25 publications

Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis

Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis

Revisiting JC virus and progressive multifocal leukoencephalopathy

Routine MR Imaging Protocol and Standardization in Central Nervous System Demyelinating Diseases

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