2021
DOI: 10.1016/j.msard.2021.102964
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Progressive myelopathy in myelin oligodendrocyte glycoprotein antibody-associated disease: A new mimicker of progressive multiple sclerosis?

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Cited by 9 publications
(5 citation statements)
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“…Progressive cases of MOGAD are rare, with only seven reported to date. [1][2][3] In this patient, the initial presentation with ADEM was in keeping with the agedependent pattern reported in other large cohorts. [4][5][6] In children with onset <10 years, the most common MOG-IgG-associated presentation is ADEM, while in adults ON and/or TM predominate.…”
Section: Discussionsupporting
confidence: 87%
“…Progressive cases of MOGAD are rare, with only seven reported to date. [1][2][3] In this patient, the initial presentation with ADEM was in keeping with the agedependent pattern reported in other large cohorts. [4][5][6] In children with onset <10 years, the most common MOG-IgG-associated presentation is ADEM, while in adults ON and/or TM predominate.…”
Section: Discussionsupporting
confidence: 87%
“…Although a chronic onset has been shown to be a useful discriminator for noninflammatory myelopathy, a longer progression to nadir has been described in cases of AQP4-IgG NMOSD-LETM and MOGAD-LETM. 18,19 In our cohort, two AQP4-IgG NMOSD-LETM and two MOGAD patients had a chronic disease onset. Five dsLETM patients (18%) progressed to symptom nadir by a median of 60 days.…”
Section: Discussionmentioning
confidence: 91%
“…International panel group for MOGAD diagnostic criteria have recommended avoiding MOG-IgG screening of all patients with CNS inflammatory demyelination, and a cautious interpretation of positive results in patients with atypical findings for MOGAD [ 2 ]. We agree that such a prudent stance is appropriate; however, since atypical manifestations including progressive myelopathy or combined peripheral neuropathy with MOG-IgG have been reported [ 11 , 12 ] and the significance of clear positivity of serum MOG-IgG in patients with atypical phenotype is yet to be elucidated, more substantial data are needed for defining the spectrum of MOGAD phenotype. MOG-IgG testing should be considered in these contexts in image-negative myelopathy patients, particularly if no better explanation is identified even though extensive work-up yields negative results.…”
mentioning
confidence: 87%