Progressive nodular histiocytosis: a rare type of xanthogranuloma

Chuang, Fei‐Chi; Chern, Erick; Wu, Weiming

doi:10.1016/j.dsi.2011.07.005

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…The clinical course of PNH is characteristically relentless without spontaneous remission. Lesions increase in number and size over time and can be markedly disfiguring [7][8][9][10]. Mucosal involvement may occur [9,10], but internal organs are not usually affected [10].…”

Section: Discussionmentioning

confidence: 99%

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Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature

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Pukhalskaya

Bowman

et al. 2021

Case Reports in Pathology

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Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehead and right temple. These lesions were initially diagnosed as xanthomas and did not respond to intralesional injections of triamcinolone. Additional biopsy revealed an intense dermal infiltrate of foamy mononuclear epithelioid cells with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. On immunohistochemical staining, the lesional cells were positive for CD163 and CD68 and negative for CD1a, thus confirming a mononuclear-macrophage lineage. The clinical presentation and the histological impression lead to the diagnosis of PNH. This condition could be challenging, mimicking microscopically similar lesions of the non-Langerhans cell histiocytosis group. Although uncommon, PNH stands out due to its clinical and microscopic features and should be taken into consideration in the differential diagnosis of cutaneous histiocytoses.

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Section: Discussionmentioning

confidence: 99%

“…However, DF/BFH are most commonly solitary, nonprogressive lesions and are thus lower in the clinical differential diagnosis. Owing to its predominant cutaneous manifestation, detailed systemic workup (other than perhaps a lipid profile) is usually not required for diagnosis or management, unless indicated by the patient's symptoms [8].…”

Section: Discussionmentioning

confidence: 99%

Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature

Numbere

Pukhalskaya

Bowman

et al. 2021

Case Reports in Pathology

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“…Oropharyngeal and laryngeal involvement can lead to dyspnea and dysphagia. [ 2 ] Ocular involvement in the form of epibulbar infiltrates[ 2 ] and association with Eale's disease has been reported. [ 3 ] Chemotherapy with corticosteroids, methotrexate, imatinib, and vinblastin has been tried with variable success and the disease is often treatment resistant.…”

Section: Discussionmentioning

confidence: 99%

Disfiguring periocular yellow nodules in a normolipemic patient

Kamat

Madakshira

Dogra

2020

Indian J Ophthalmol

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“…There may be mucosal involvement with oral, laryngeal, and/or conjunctival lesions noted . PNH is a mainly cutaneous histiocytosis without systemic findings . However, cases have been reported in association with precocious puberty, growth hormone deficiency, chronic myeloid leukemia, hypothyroidism, and lipoprotein metabolic changes.…”

Section: Discussionmentioning

confidence: 99%

“…3 PNH is a mainly cutaneous histiocytosis without systemic findings. 4 However, cases have been reported in association with precocious puberty, growth hormone deficiency, chronic myeloid leukemia, hypothyroidism, and lipoprotein metabolic changes. Treatment with systemic corticosteroids, cyclophosphamide, vincristine, azathioprine, 6mercaptopurine, and methotrexate have been attempted.…”

Section: Histopathological and Other Findingsmentioning

confidence: 99%