Progressive noninfectious anterior vertebral fusion

Abstract

A 9-year-old girl with back pain showed progressive spinal mobility restriction since age one, without a history of spondylodiscitis or neurological deficits. Laboratory tests were normal. Radiographs revealed lumbar lordosis rectification, anterior fusion between end plates from L2-L3 to L4-L5 levels, with prominent bone bridge in the latter, and anterior intervertebral narrowing at T11-T12 and L1-L2 (Fig.

Presentation and outcome of patients treated non-operatively or operatively for Copenhagen Disease: a 30-year experience

“…In the current literature, only 66 cases have been described, mostly as case reports [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], with the largest series from the University Hospital of Copenhagen, lending its name to this condition [1]. However, Mosenthal was the first to fully describe this condition in 1931 [18].…”

An N‐Ethyl‐N‐Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

“…K yphosis is a common disorder of the vertebral column (1) that can occur in isolation, or in association with scoliosis in infants (2) and adolescents, (3) and osteoporosis in the elderly, (1) causing pain, decreased function and activity, (1) and increased risk of mortality in older women above the age of 65 years. (1,4) Kyphosis, scoliosis, or kyphoscoliosis, can occur at any age, secondary to other underlying developmental, musculoskeletal, neuromuscular, or spinal disorders, (5)(6)(7)(8)(9)(10) and may be part of complex disorders such as the CHARGE syndrome (coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness), (9,11) or occur as a nonsyndromic condition. Indeed, the most common forms of kyphosis and scoliosis in adolescents are nonsyndromic and include: Scheuermann disease (3) a form of nonsyndromic kyphosis, which affects >8% of the population (12) ; idiopathic scoliosis (IS), which affects approximately 2% to 3% individuals (13)(14)(15)(16) ; and congenital nonsyndromic scoliosis, which is reported to have a prevalence of approximately 0.5 to 1 per 1000 individuals.…”