Progressive periodontal disease has a simultaneous incremental elevation of gingival crevicular fluid and serum CRP levels

Pradeep, A.R.; Manjunath, Ramanathapuram

doi:10.1111/j.2041-1626.2010.00022.x

Cited by 32 publications

(43 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the present study are in accordance with those of previous study in which serum PGRN levels were elevated in diabetic subjects [17]. The increase in serum and GCF concentrations of hs-CRP from health to chronic periodontitis to chronic periodontitis with DM in the present study is in accordance with a previous study [39]. We further found significant relationship between PGRN and hs-CRP concentrations.…”

Section: Discussionsupporting

confidence: 93%

Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes

et al. 2013

View full text Add to dashboard Cite

Introduction. This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM). Design. PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodontitis, and type 2 DM with chronic periodontitis. Results. The mean PGRN and hs CRP concentrations in serum and GCF were the highest for group 3 followed by group 2 and the least in group 1. Conclusion. PGRN and hs CRP may be biomarkers of the inflammatory response in type 2 DM and chronic periodontitis.

show abstract

Section: Discussionsupporting

confidence: 93%

Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The results of the present study are in accordance with that of previous study in which elevated serum PGRN levels in obese subjects were reported [20]. The increase in serum and GCF concentrations of hs-CRP in the present study are in accordance with a previous study [39]. In contrast to a previous study [40] which demonstrated almost non detectable amount of hs-CRP in GCF, we detected sufficiently large amount in GCF.…”

Section: Discussionsupporting

confidence: 92%

Association of Progranulin and High Sensitivity CRP Concentrations in Gingival Crevicular Fluid and Serum in Chronic Periodontitis Subjects with and without Obesity

et al. 2012

View full text Add to dashboard Cite

Background: Obesity is considered as a strong risk factor of inflammatory periodontal tissue destruction. The purpose of this study is to determine presence of progranulin (PGRN) and high sensitivity C reactive protein (hs CRP) levels in serum and gingival crevicular fluid (GCF) in obese subjects with chronic periodontitis and to find an association, if any.Material and methods: 40 subjects (20 males and 20 females) were selected based on their clinical parameters into four groups (10 subjects in each group): group 1 (healthy non obese), group 2 (healthy obese), group 3 (non obese with chronic periodontitis) and group 4 (obese with chronic periodontitis). Serum and GCF PGRN levels were estimated by enzyme linked immunosorbant assay (ELISA) and hs CRP levels were estimated by immunoturbidimetry method.Results: The mean PGRN and hs CRP concentration both in serum and GCF were highest for group 4 followed by group 3, group 2 and least in Group 1.Conclusion: PGRN and hs CRP may be novel biomarkers of the chronic inflammatory response in obesity and chronic periodontitis.

show abstract

“…It was anticipated that such a comparison and correlation would further validate the role of the new molecule (in this case, SCF) being tested. The observed increase in hs-CRP, an acute-phase reactant protein and one of the most important markers of inflammation from Group 1 to Group 2, was in accord with a previous study by Pradeep et al in which CRP levels in GCF and serum were measured using ELISA (24), and also with a study by Noack et al (11) The mean GCF concentration of CRP in the periodontitis group was very much higher than that in the gingivitis group and healthy group. Similarly, the mean serum concentration of CRP in the periodontitis group was higher than that in the gingivitis group, which in turn was higher than that in the healthy group.…”

Section: Discussionsupporting

confidence: 91%

Association of stem cell factor and high-sensitivity C reactive protein concentrations in crevicular fluid and serum in patients with chronic periodontitis with and without type 2 diabetes

et al. 2013

View full text Add to dashboard Cite

Abstract:The aim of the present study was to clarify whether there is any correlation between the levels of high-sensitivity C reactive protein (hs-CRP) and stem cell factor (SCF) in serum and gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (DM). A total of 40 subjects were divided into 3 groups: 10 periodontally healthy subjects (Group 1), 15 CP patients (Group 2), and 15 type 2 DM patients with CP (Group 3). Levels of hs-CRP and SCF in GCF and serum were quantified using different techniques. The clinical outcomes evaluated were gingival index (GI), probing depth (PD) and clinical attachment level (CAL), and the correlations of the two inflammatory mediators with clinical parameters were evaluated. The levels of these inflammatory mediators increased continuously from group 1 to group 2, and to group 3. The serum levels of both hs-CRP and SCF were correlated with PD in patients with CP (P < 0.05). SCF levels were correlated with PD in Group 3 (P < 0.05). The fact that the levels of hs-CRP and SCF were highest in DM patients with CP suggests that the presence of a systemic condition has a profound effect on the levels of inflammatory mediators, both locally at sites of periodontal disease, and elsewhere. (J Oral Sci 55, 57-62, 2013)

show abstract

Progressive periodontal disease has a simultaneous incremental elevation of gingival crevicular fluid and serum CRP levels

Cited by 32 publications

References 37 publications

Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes

Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes

Association of Progranulin and High Sensitivity CRP Concentrations in Gingival Crevicular Fluid and Serum in Chronic Periodontitis Subjects with and without Obesity

Association of stem cell factor and high-sensitivity C reactive protein concentrations in crevicular fluid and serum in patients with chronic periodontitis with and without type 2 diabetes

Contact Info

Product

Resources

About