Progressive Pigmentation of Whole Body Mimicking Hereditary Reticulate Pigmentation in a Young Girl: A Rare Presentation of Amyloid Cutis Dyschromica

Abstract

Primary cutaneous amyloidosis is a chronic, progressive disorder of skin, because of the amyloid deposition in the skin with no systemic involvement. Amyloid cutis dyschromica (ACD) is considered a rare variant of primary cutaneous amyloidosis with around 50 cases reported so far. Most cases are reported from Asia, majority having the family history. Autosomal recessive inheritance in GPNMB encoding glycoprotein non metastatic gene B has been reported in many cases with few case reports of semidominat inheritance. It is usually asymptomatic condition as opposed to other types of primary cutaneous amyloidosis like macular or lichenoid variant which are associated with moderate to severe pruritus and photosensitvity. Chief complaint in majority of cases is cosmetic concern only. In view of the very few cases reported from India, we hereby report the case of a 28 years old female having similar dyspigmentation in one sibling.