Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: Insights for psychosis treatment

Bartolomeis, Andrea de; Iasevoli, Felice; Marmo, Federica; Buonaguro, Elisabetta Filomena; Eramo, Anna; Rossi, Rodolfo; Avvisati, Livia; Latte, Gianmarco; Tomasetti, Carmine

doi:10.1016/j.euroneuro.2015.01.003

Cited by 26 publications

(27 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the molecular underpinnings of EGR1 alterations in schizophrenia remain unknown, knockdown in cultured hippocampal GABA neurons of the histone deacetylase 1 (HDAC1) and its co-repressor DAXX, whose expressions are also altered in schizophrenia, results in increased GAD1 and Egr1 mRNA levels, which opens the possibility for an HDAC1/DAXX-mediated repression of EGR1 expression leading to GAD1 inhibition (Subburaju et al, 2016). Furthermore, beyond its etiology, EGR1 is also associated with response to antipsychotic drugs (MacGibbon et al, 1994; Robbins et al, 2008; Bruins Slot et al, 2009; Wheeler et al, 2014; de Bartolomeis et al, 2015), or the psychomimetic phencyclidine in rats (Tamminga et al, 1995; Näkki et al, 1996). …”

Section: Egr1 Role In Pathological Statesmentioning

confidence: 99%

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Duclot

Kabbaj

2017

Front. Behav. Neurosci.

283

240

View full text Add to dashboard Cite

It is now clearly established that complex interactions between genes and environment are involved in multiple aspects of neuropsychiatric disorders, from determining an individual’s vulnerability to onset, to influencing its response to therapeutic intervention. In this perspective, it appears crucial to better understand how the organism reacts to environmental stimuli and provide a coordinated and adapted response. In the central nervous system, neuronal plasticity and neurotransmission are among the major processes integrating such complex interactions between genes and environmental stimuli. In particular, immediate early genes (IEGs) are critical components of these interactions as they provide the molecular framework for a rapid and dynamic response to neuronal activity while opening the possibility for a lasting and sustained adaptation through regulation of the expression of a wide range of genes. As a result, IEGs have been tightly associated with neuronal activity as well as a variety of higher order processes within the central nervous system such as learning, memory and sensitivity to reward. The immediate early gene and transcription factor early growth response 1 (EGR1) has thus been revealed as a major mediator and regulator of synaptic plasticity and neuronal activity in both physiological and pathological conditions. In this review article, we will focus on the role of EGR1 in the central nervous system. First, we will summarize the different factors influencing its activity. Then, we will analyze the amount of data, including genome-wide, that has emerged in the recent years describing the wide variety of genes, pathways and biological functions regulated directly or indirectly by EGR1. We will thus be able to gain better insights into the mechanisms underlying EGR1’s functions in physiological neuronal activity. Finally, we will discuss and illustrate the role of EGR1 in pathological states with a particular interest in cognitive functions and neuropsychiatric disorders.

show abstract

Section: Egr1 Role In Pathological Statesmentioning

confidence: 99%

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Duclot

Kabbaj

2017

Front. Behav. Neurosci.

283

240

View full text Add to dashboard Cite

show abstract

“…Here we show a representative depiction of Homer1a IEG expression by different antipsychotics acutely administered in rodents. The autoradiographic film images of Homer1a mRNA detected by means of in situ hybridization histochemistry in coronal brain sections have been extracted from different studies carried on by our laboratory (Polese et al, 2002 ; Ambesi-Impiombato et al, 2007 ; Tomasetti et al, 2007 , 2011 ; Iasevoli et al, 2009 , 2010a , b , 2011 ; De Bartolomeis et al, 2015a ) and representatively placed side by side in order to outline gene expression topography after treatments with haloperidol (HAL), olanzapine (OLA), sertindole (SERT), amisulpiride (AMS), risperidone (RISP), clozapine (CLO), and different doses of ziprasidone (4 mg/kg, ZIP4; 10 mg/kg, ZIP10), aripriprazole (12 mg/kg, ARI12; 30 mg/kg, ARI30), quetiapine (15 mg/kg, QUE15; 30 mg/kg, QUE30). Homer1a is a postsynaptic effector of plastic synaptic changes mainly mediated by dopamine and glutamate-dependent signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Acute antipsychotics administration has been demonstrated to impact signal-transduction pathways in specific brain regions with significant implications for long-term treatment (De Bartolomeis et al, 2013b , 2015a ). For instance, acute i.v.…”

Section: Introductionmentioning

confidence: 99%

Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes

Bartolomeis

Buonaguro

Latte

et al. 2017

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

An increasing amount of research aims at recognizing the molecular mechanisms involved in long-lasting brain architectural changes induced by antipsychotic treatments. Although both structural and functional modifications have been identified following acute antipsychotic administration in humans, currently there is scarce knowledge on the enduring consequences of these acute changes. New insights in immediate-early genes (IEGs) modulation following acute or chronic antipsychotic administration may help to fill the gap between primary molecular response and putative long-term changes. Moreover, a critical appraisal of the spatial and temporal patterns of IEGs expression may shed light on the functional “signature” of antipsychotics, such as the propensity to induce motor side effects, the potential neurobiological mechanisms underlying the differences between antipsychotics beyond D2 dopamine receptor affinity, as well as the relevant effects of brain region-specificity in their mechanisms of action. The interest for brain IEGs modulation after antipsychotic treatments has been revitalized by breakthrough findings such as the role of early genes in schizophrenia pathophysiology, the involvement of IEGs in epigenetic mechanisms relevant for cognition, and in neuronal mapping by means of IEGs expression profiling. Here we critically review the evidence on the differential modulation of IEGs by antipsychotics, highlighting the association between IEGs expression and neuroplasticity changes in brain regions impacted by antipsychotics, trying to elucidate the molecular mechanisms underpinning the effects of this class of drugs on psychotic, cognitive and behavioral symptoms.

show abstract

“…Both antipsychotics and antidepressants modulate PSD molecules to play roles in behavioral response. [83][84][85][86][87][88][89][90] Among them, PSD95 is a member of the synapse-associated protein family of scaffolding molecules that modulates the organization and function of synapses. 91) Interestingly, Hirabayashi et al 92) purified a PSD-95 fusion protein coupled to three tandem repeats of MT (PSD95-3MT) from COS7 cells grown in the presence of Cd 2+ .…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Physiological Roles of Metallothioneins in Central Nervous System Diseases

Nakamura

Shimazawa

Hara

2018

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Metallothioneins (MTs) are small-molecular weight metal-binding proteins involved in the maintenance of tissue structure, efficient metal metabolism, and metal detoxification and have an antioxidative effect. Moreover, MTs are expressed as four isoforms, and there are no known patterns in their localization with various effects. According to recent studies, MTs affect central nervous system (CNS) diseases, and many reports suggest that each isoform of MT has a protective effect against disease. Notably, MTs are involved in regions of diseases related to unmet medical needs, and MTs affect intractable neurological diseases, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). This review specifically focuses on MT-related ocular diseases, cerebral ischemia, psychological disorders, ALS, and SMA. Each of these diseases has a separate cause, but the conditions are related to MTs. To understand the physiological roles of MTs in CNS diseases, we reviewed the current literature on the complex interactions between each MT, pathological conditions, and perspectives. We also discuss current evidence on the expression and function of MTs for diagnosis and new therapeutic strategies.

show abstract

Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: Insights for psychosis treatment

Cited by 26 publications

References 45 publications

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes

Physiological Roles of Metallothioneins in Central Nervous System Diseases

Contact Info

Product

Resources

About