Progressive resolution of exudation from perifoveal vascular anomalous complex: A possible role of diclofenac therapy?

Long-Term Resolution of Perifoveal Exudative Vascular Anomalous Complex after Intravitreal Injections of Anti-Vascular Endothelial Growth Factor

“…(For figure see next page.) location of the lesion allowed to perform the photocoagulation [7,12], and recently one case reported by Tombolini and associates improvement after 1 month of a topical non-steroidal anti-inflammatory drug [13].…”

“…Different publications are consistent with this statement, but the number of total injections from patients who received treatment with anti-VEGF intravitreal injections ranged from just one to a total of four [ 1 , 3 , 4 , 6 , 9 , 10 , 11 ], except for 1 patient treated by Mrejen et al [ 7 ], which showed sustainable resolution of the exudation after 13 anti-VEGF injections, and a patient with PEVAC associated with a lamellar hole who partially responded to 3 injections of ranibizumab with a significant decrease of the edema [ 8 ]. In addition, other publications have demonstrated a good response to laser therapy, when the location of the lesion allowed to perform the photocoagulation [ 7 , 12 ], and recently one case reported by Tombolini and associates improvement after 1 month of a topical non-steroidal anti-inflammatory drug [ 13 ].…”

Perifoveal Vascular Anomalous Complex and the spectrum of degenerative microvascular macular diseases

“…16 Exudative PVAC is usually not responsive to anti-VEGF injections, even if a relative response of exudative signs were reported in sporadic cases. [14][15][16][17] Focal laser photocoagulation 14 and topical antiinflammatory therapy 18 showed some positive results, with resolution of the exudation. However, the authors cautioned these results because a variable number of spontaneous regressions of exudation have been reported.…”