Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification

Matsuo, Hidemasa; Handa, Tomohiro; Tsuchiya, Michiko; Kubo, Takeshi; Yoshizawa, Akihiko; Nakayama, Yuko; Shiga, Shuichi; Hitomi, Takefumi; Adachi, Souichi; Date, Hiroshi; Hirai, Toyohiro; Ichiyama, Satoshi

doi:10.2169/internalmedicine.9433-17

Cited by 17 publications

(20 citation statements)

References 22 publications

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“…Clinically speaking, majority of patients are either asymptomatic at the time of presentation or they might exhibit mild cough or dyspnoea [ 6 ]. Pneumothorax is a rare complication of DPO according to the available reports [ 2 , 12 - 17 ]. Our case was asymptomatic at the time of presentation and remained so at his last visit to our respiratory clinic.…”

Section: Discussionmentioning

confidence: 99%

First Case of Dendriform Pulmonary Ossification in Bahrain

Naser

Alwedaie

Kadhem

2021

Cureus

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Dendriform pulmonary ossification (DPO) is a rare interstitial lung disease characterised by the presence of mature bone with marrow elements in the lung parenchyma with typical radiologic findings of diffuse and numerous calcified nodules. In this case study, we are presenting a case of asymptomatic primary DPO discovered during routine screening chest X-ray. To our best knowledge, this is the first case of DPO reported in Bahrain.

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Section: Discussionmentioning

confidence: 99%

First Case of Dendriform Pulmonary Ossification in Bahrain

Naser

Alwedaie

Kadhem

2021

Cureus

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“…DPO is generally considered to be indolent or slowly progressive, inducing a gradual decline in the pulmonary function ( 4 - 6 ). However, there was a case report of a patient with idiopathic DPO who showed no significant deterioration for one decade ( 11 ), and another case with progressive restrictive ventilatory impairment due to idiopathic DPO ( 12 ). No proven treatment has been developed for pulmonary ossification ( 1 , 4 , 6 ), and remission has yet to be described ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

Three Cases of Idiopathic Diffuse Pulmonary Ossification

et al. 2019

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Diffuse pulmonary ossification (DPO) is an uncommon diffuse lung disease characterized by metaplastic bone formation in the lung parenchyma and is rarely diagnosed in life. While DPO usually occurs as a secondary disease, idiopathic cases are extremely rare. We describe three cases of idiopathic DPO, two of which were definitively diagnosed by surgical lung biopsy. One case was observed in a 43-year-old man with a history of recurrent pneumothorax who developed pneumothorax after the surgical biopsy. Few reports have described cases of DPO with recurrent pneumothorax; however, pneumothorax should be considered as a potential complication when such patients are encountered.

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“…Nodular DPO usually occurs in situations of chronic congestion, such as mitral valve stenosis. On the other hand, dendriform DPO occurs secondary to acute or chronic damage of the lung, such as idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and chronic obstructive pulmonary disease [9, 10]. In the case reported herein, the ossification was of the dendriform type; however, no abnormalities were observed in the background lung, and the cause of the ossification remained unclear.…”

Section: Discussionmentioning

confidence: 86%

Spontaneous pulmonary hematoma with diffuse pulmonary ossification requiring emergency treatment: a case report

et al. 2019

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Background Pulmonary hematoma is most often caused by thoracic trauma. However, rare cases of pulmonary hematoma without any obvious cause are sometimes reported, when the condition is referred to as spontaneous or idiopathic pulmonary hematoma. Herein, we report a very rare case—to the best of our knowledge, this is the first case of pulmonary hematoma associated with diffuse pulmonary ossification requiring emergency treatment reported in the English literature. Case presentation Our patient was a 44-year-old man with a history of IgA nephropathy and had no history of trauma or anticoagulant use. He presented with the chief complaint of bloody sputum and was referred to our hospital for detailed examination. Chest computed tomography showed a right pleural effusion and a large round mass in the right lower lobe. We performed chest tube drainage of the right thorax and confirmed bloody pleural effusion. Although bronchial artery embolization was performed, the patient’s anemia worsened, and we performed right lower lobectomy. Histopathological examination of the resected specimen showed a hematoma with diffuse pulmonary ossification, although the relationship between the two was unclear. There was no evidence of malignancy or angiitis. Therefore, we made the diagnosis of spontaneous pulmonary hematoma in this case. The postoperative course was uneventful. The patient is currently under observation as an outpatient, and a recent chest X-ray showed no evidence of recurrence. Conclusion We report a case of spontaneous pulmonary hematoma with diffuse pulmonary ossification. Although the relationship between the two remains unclear, considering the possibility of appearance of new lesions/recurrence, we believe that careful follow-up is necessary for this patient.

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Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification

Cited by 17 publications

References 22 publications

First Case of Dendriform Pulmonary Ossification in Bahrain

First Case of Dendriform Pulmonary Ossification in Bahrain

Three Cases of Idiopathic Diffuse Pulmonary Ossification

Spontaneous pulmonary hematoma with diffuse pulmonary ossification requiring emergency treatment: a case report

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