Progressive retinal ganglion cell loss in primary open-angle glaucoma is associated with temperature circadian rhythm phase delay and compromised sleep

Gubin, Denis; Малишевская, Т. Н.; Astakhov, Yury S.; Astakhov, Sergey Yu.; Cornélissen, Germaine; Кузнецов, В. А.; Weinert, Dietmar

doi:10.1080/07420528.2019.1566741

Cited by 37 publications

(39 citation statements)

References 85 publications

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“…On the other hand, despite this background, glaucoma has been reported to be associated with a high incidence of sleep disorders [213][214][215], seasonal affective disorder or depression, and anxiety [216]. Some circadian rhythm abnormalities may induce sleep and mood disorders as a result of loss in vision due to glaucoma progression [215,217]. Exactly how the mechanism of glaucoma may induce sleep problems is not clear, but one possibility is that the ipRGC loss that occurs in glaucoma results in decreased light inputs to the SCN via retino-hypothalamic tract.…”

Section: Circadian Rhythm Of Melatonin and Glaucomamentioning

confidence: 99%

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

et al. 2021

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Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play an important role in the eye to regulate the homeostasis and even to treat some ocular conditions. As a result, many ocular pathologies like dry eye, corneal wound healing, cataracts, myopia, retinal diseases, and glaucoma are affected by this cycle. This review will summarize the current scientific literature about the influence of circadian patterns on the eye, focusing on its relationship with increased intraocular pressure (IOP) fluctuations and glaucoma. Regarding treatments, two ways should be studied: the first one, to analyze if some treatments could improve their effect on the ocular disease when their posology is established in function of circadian patterns, and the second one, to evaluate new drugs to treat eye pathologies related to the circadian rhythm, as it has been stated with melatonin or its analogs, that not only could be used as the main treatment but as coadjutant, improving the circadian pattern or its antioxidant and antiangiogenic properties.

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Section: Circadian Rhythm Of Melatonin and Glaucomamentioning

confidence: 99%

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

et al. 2021

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“…Chromatic pupillometry has been used in other conditions as a marker of mRGC integrity (62). In primary open angle glaucoma, a condition associated with histological mRGC loss (63), abnormal melatonin secretion profile (64) and sleep and circadian rhythm dysfunction (65), various pupillometric studies have shown abnormal PLR responses (28, 66–70). Conversely, in mitochondrial hereditary optic neuropathies, mRGCs are resistant to neurodegeneration, explaining the relatively preserved chromatic pupillometry parameters (71–73) and melatonin profiles (74).…”

Section: Pathophysiology Of Light-induced Pupillary Responses In Admentioning

confidence: 99%

Light-Induced Pupillary Responses in Alzheimer's Disease

et al. 2019

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The impact of Alzheimer's disease (AD) on the pupillary light response (PLR) is controversial, being dependent on the stage of the disease and on the experimental pupillometric protocols. The main hypothesis driving pupillometry research in AD is based on the concept that the AD-related neurodegeneration affects both the parasympathetic and the sympathetic arms of the PLR (cholinergic and noradrenergic theory), combined with additional alterations of the afferent limb, involving the melanopsin expressing retinal ganglion cells (mRGCs), subserving the PLR. Only a few studies have evaluated the value of pupillometry as a potential biomarker in AD, providing various results compatible with parasympathetic dysfunction, displaying increased latency of pupillary constriction to light, decreased constriction amplitude, faster redilation after light offset, decreased maximum velocity of constriction (MCV) and maximum constriction acceleration (MCA) compared to controls. Decreased MCV and MCA appeared to be the most accurate of all PLR parameters allowing differentiation between AD and healthy controls while increased post-illumination pupillary response was the most consistent feature, however, these results could not be replicated by more recent studies, focusing on early and pre-clinical stages of the disease. Whether static or dynamic pupillometry yields useful biomarkers for AD screening or diagnosis remains unclear. In this review, we synopsize the current knowledge on pupillometric features in AD and other neurodegenerative diseases, and discuss potential roles of pupillometry in AD detection, diagnosis and monitoring, alone or in combination with additional biomarkers.

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“…Several studies have linked glaucoma and disturbances in mood and sleep [8][9][10][11][12]20,[35][36][37][38][39]. Visual field defects are associated with lower sleep quality, increased daytime-sleepiness and higher levels of self-reported anxiety and depression and [8][9][10]35].…”

Section: Discussionmentioning

confidence: 99%