Proguanil versus Sulphadoxine-Pyrimethamine for Malaria Chemoprophylaxis in Pregnancy: A Randomised Controlled Trial

Kasso, Terhemen; Jeremiah, Israel; John, Celestine T.

doi:10.4172/2167-0870.1000122

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…It is estimated that about the 50 million women worldwide living in malaria endemic countries become pregnant, of whom the majority live in tropical Africa which has a high transmission rate of Plasmodium falciparum. About 10000 of these women and 200000 infants die as a consequence of malaria infection during pregnancy (6). Sub-Saharan Africa is home to an estimated 25 -30 million pregnant women who are at the risk of infection, of whom 25% show evidence of placental malaria (2,7,8).…”

Section: Introductionmentioning

confidence: 99%

Effects of Intervention Schemes on Sulphadoxine-Pyrimethamine Compliance Among Pregnant Women in a Health Facility in Port Harcourt, Rivers State, Nigeria

2021

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Background: Malaria causes diverse adverse effects in the fetus due to the invasion of the placenta by Plasmodium. The use of intermittent preventive treatment (Sulphadoxinepyrimethamine- IPTp-SP) as a control measure for malaria in pregnancy has been recommended and shown to reduce unwanted birth outcomes. Objectives: This work aimed to evaluate the effects of intervention schemes on sulphadoxine-pyrimethamine (SP) compliance and utilization among pregnant women in a health facility in Port Harcourt, Nigeria. Methods: A hospital-based survey was carried out among pregnant women admitted to the Labor ward of Obio-Cottage hospital. The information of mothers was collected using a well-structured and pre-tested questionnaire and from their antenatal care (ANC) records. Results: Time of ANC registration indicated that 87%, 11.33%, and 1.66% of mothers were registered during their first, second, and third trimesters, respectively. Sulphadoxinepyrimethamine was the drug of choice for 93.66% of the women while 6.33% took other drugs. The survey revealed that 97.15% and 2.85% of the women started SP usage in their second and third trimesters, respectively. It was observed that the majority of the women (69.39%) took SP thrice while 24.19% and 6.40% consumed it twice and once, respectively. Regarding knowledge about SP, 89% of the women viewed SP as a preventive drug for malaria while 11% acknowledged it as a therapeutic drug. The birth outcomes of the neonates whose mothers took SP indicated that 1.42% had low birth weight (LBW) while 98.57% had acceptable birth weight. Meanwhile, 10.53% of the babies born to the mothers who did not use SP had LBW, and 89.47% of them had acceptable birth weights. Overall, 98.93% of the neonates of SP-compliant women and 89.48% of the babies of non-compliant women were alive. Non- compliant women had higher prevalence of preterm birth (5.76%) and fetal death (5.26%) than SP-compliant women (0.7% and 0.35%, respectively). Conclusions: Adequate knowledge and compliance with SP usage were high in the studied population, which was associated with favorable birth outcomes.

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Section: Introductionmentioning

confidence: 99%

Effects of Intervention Schemes on Sulphadoxine-Pyrimethamine Compliance Among Pregnant Women in a Health Facility in Port Harcourt, Rivers State, Nigeria

2021

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Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Tsegaye¹,

Tesfaye²

2014

Int. Res. J. Pharm.

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Anemia is a major global health problem, especially in developing countries and is a common and serious problem in pregnancy. It has serious short-and long-term consequences during pregnancy and beyond. This fundamental health issue has not still been solved but continues to exist affecting the health, quality of life and working capacity in billions of people all over the world. The anemic condition is often worsened by the presence of other chronic diseases such as malaria, tuberculosis, HIV, and diabetes. Untreated anemia also leads to increased morbidity and mortality from these chronic conditions as well. Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for inferior neonatal health. Even for women who enter pregnancy with reasonable iron stores, iron supplements improve iron status during pregnancy and for a considerable length of time postpartum, thus providing some protection against iron deficiency in the subsequent pregnancy. This literature review focuses on the prevalence and major causes of anemia seen on a global & Ethiopian scale. Most cases of anemia are due to iron deficiency, which often work in combination with folate deficiency and/or vitamin B12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem-we have the tools and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proved to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e. pregnant women.

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Proguanil versus Sulphadoxine-Pyrimethamine for Malaria Chemoprophylaxis in Pregnancy: A Randomised Controlled Trial

Cited by 2 publications

References 22 publications

Effects of Intervention Schemes on Sulphadoxine-Pyrimethamine Compliance Among Pregnant Women in a Health Facility in Port Harcourt, Rivers State, Nigeria

Effects of Intervention Schemes on Sulphadoxine-Pyrimethamine Compliance Among Pregnant Women in a Health Facility in Port Harcourt, Rivers State, Nigeria

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

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