The key to high productivity of plants, especially cereals, is to control lodging of cereals. Among the derivatives of acylcyclohexadiones (ACHD), highly effective retardants have been invented, which are widely used in modern crop production to control the lodging of cereals, mainly winter wheat, spring and winter wheat, winter, spring and hybrids of barley. The mechanisms of influence of ACHD derivatives – trinexapac-ethyl and prohexadione-Ca on plants and features of their application in technologies of cultivation of cultivated plants are considered. By using a composition of ACHD derivatives with a number of agrochemicals, enhancement of retardant activity is achieved. Given the identified varietal variability of the effectiveness of the use of ACHD derivatives in cereals, it is advisable to conduct registration and post-registration studies primarily on varieties that occupy the largest sown areas in the country. The peculiarities of ACHD derivatives’ influence on stem components as the main one, along with the flag leaf, carbon pool for grain filling in the ear and possible reasons for the lack of productivity increase of grain crops due to ACHD derivatives are also considered. This class of substances continues to be widely studied in the world and remains among the most promising for the development of new agrochemicals and drugs.