1995
DOI: 10.1093/rheumatology/34.1.88
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Proinflammaroty Role of Tissue Kallikrein in Modulating Paln in Inflamed Joints

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Cited by 9 publications
(2 citation statements)
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“…The kallikrein-kinin system with activation plasma (KLKB1) as well as tissue kallikrein (KLK1) has been implicated in inflammation, and raised levels of both have been found in plasma and synovial fluid of patients with RA [34] [38] . Less is known about the role of KLK6 in the pathogenesis of RA, but KLK6 has been found in synovial fluid in patients with psoriatic arthritis [39] , and KLK6 promotes survival of murine lymphocytes with actions on proteinase-activated receptor 1 [40] .…”
Section: Discussionmentioning
confidence: 99%
“…The kallikrein-kinin system with activation plasma (KLKB1) as well as tissue kallikrein (KLK1) has been implicated in inflammation, and raised levels of both have been found in plasma and synovial fluid of patients with RA [34] [38] . Less is known about the role of KLK6 in the pathogenesis of RA, but KLK6 has been found in synovial fluid in patients with psoriatic arthritis [39] , and KLK6 promotes survival of murine lymphocytes with actions on proteinase-activated receptor 1 [40] .…”
Section: Discussionmentioning
confidence: 99%
“…In previous experiments an increase in plasma and tissue kallikrein as well as kinin levels could be demonstrated in the synovial fluid of RA patients (Rahman et al, 1994(Rahman et al, , 1995. The synovitis of rheumatoid arthritis (RA) is characterised by pain and loss of cartilage and bone structure.…”
Section: Inflammatory Joint Diseasementioning
confidence: 99%