Proinflammatory and anti-inflammatory cytokines in adolescents from Southeast Bulgarian cities with different levels of air pollution

Dobreva, Zlatka Georgieva; Kostadinova, G.; Popov, B.; Petkov, G.; Stanilova, Spaska

doi:10.1177/0748233713491812

Cited by 42 publications

(29 citation statements)

References 24 publications

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“…b p-value for interaction term representing the product of NO 2 exposure and DD of asthma. increased IL10 expression and IL-10 plasma levels in children living in highly polluted areas (Calderon-Garcidueñas et al 2009;Dobreva et al 2015), which is also supported by in vitro studies (Saito et al 2002).…”

Section: Discussionsupporting

confidence: 55%

Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Gruzieva¹,

Merid²,

Gref³

et al. 2016

ISEE Conference Abstracts

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BACKGROUND: Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood. OBJECTIVES: We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children. METHODS:We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (NO 2 ) and particulate matter (PM) with aerodynamic diameter <10 lm (PM 10 ) from road traffic were estimated for residential, daycare, and school addresses using dispersion modeling. Timeweighted average exposures during infancy and at biosampling were linked to serum cytokine levels using linear regression analysis. Furthermore, gene expression data from 16-year-olds in BAMSE (n = 238) were used to evaluate links between air pollution exposure and expression of genes coding for the studied inflammatory markers. RESULTS: A 10 lg=m 3 increase of NO 2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. However, no clear associations were observed for current exposure. Results were similar using PM 10 , which showed a high correlation with NO 2 . The functional analysis identified several differentially expressed genes in response to air pollution exposure during infancy, including IL10, IL13, and TNF. CONCLUSION: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.

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Section: Discussionsupporting

confidence: 55%

Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Gruzieva¹,

Merid²,

Gref³

et al. 2016

ISEE Conference Abstracts

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“…The increased level of IL-10 after exposure to air pollutants such as diesel exhaust in the airways of patients with asthma indicates that air pollution may induce subtle changes in airway immunobiology ( Leem et al 2005 ). Furthermore, several studies reported increased IL10 expression and IL-10 plasma levels in children living in highly polluted areas ( Calderon-Garcidueñas et al 2009 ; Dobreva et al 2015 ), which is also supported by in vitro studies ( Saito et al 2002 ).…”

Section: Discussionmentioning

confidence: 52%

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children

Gruzieva

Merid

Gref

et al. 2017

Environ Health Perspect

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Background:Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood.Objectives:We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children.Methods:We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (NO2) and particulate matter (PM) with aerodynamic diameter <10μm (PM10) from road traffic were estimated for residential, daycare, and school addresses using dispersion modeling. Time-weighted average exposures during infancy and at biosampling were linked to serum cytokine levels using linear regression analysis. Furthermore, gene expression data from 16-year-olds in BAMSE (n=238) were used to evaluate links between air pollution exposure and expression of genes coding for the studied inflammatory markers.Results:A 10 μg/m3 increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. However, no clear associations were observed for current exposure. Results were similar using PM10, which showed a high correlation with NO2. The functional analysis identified several differentially expressed genes in response to air pollution exposure during infancy, including IL10, IL13, and TNF.Conclusion:Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.org/10.1289/EHP460

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“…However, some studies found that high concentration of TNF-α was detrimental as it may induce cell death, while low levels were protective and were believed to participate in normal lung function (Kleinbongard et al, 2011). Dobreva et al (2015) found a low level of serum TNF-α but a high level of IL-10 in adolescents living in highly industrialized cities. Different from our observations, Xu et al (2016) also found that serum TNF-α of mice increased significantly after exposure to PM 2.5 via inhalation.…”

Section: Oxidative Damage and Inflammatory Responsementioning

confidence: 99%

PM2.5 Meets Blood: In vivo Damages and Immune Defense

Zhang

Kang

Chen

et al. 2018

Aerosol Air Qual. Res.

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Recent evidence shows that inhaled PM 2.5 can enter the blood circulatory system and even the brain. However, the damage of blood-borne PM 2.5 is not clearly elucidated. This work aims to understand and characterize the toxicity, i.e., the acute health effects, of PM 2.5 that is directly injected into the blood circulatory system. Rats were injected with different dosages (568, the equivalent of 1 year of inhalation for a rat; 93; and 9.3 µg) of PM 2.5 sampled from Beijing via a sterile catheter injected into the jugular vein. The behaviors of the rats upon external interruptions were recorded. Blood samples were collected before exposure and 1 h, 3 days, 5 days, 7 days, and 9 days after the PM 2.5 injection for analyzing serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), endotoxin, and 8-hydroxydeoxyguanosine (8-OHdG) levels. After euthanization, the heart, lung, liver, kidney, and spleen were taken and processed for histopathological analysis. PM 2.5 components were also analyzed. Acute inflammation with 102% and 90% increases for IL-6 and CRP, respectively, was observed 1 h after the 568 µg-PM 2.5 injection, while oxidative DNA damage occurred only five or more days later, which was accompanied by significantly elevated endotoxin levels. Hemorrhage of lung alveoli and behavioral changes, including fear and non-responsiveness, were also observed. Surprisingly, all exposed rats seemingly survived the PM 2.5 injection, behaving similarly to the control groups. The immune defense might have played an important role in combating the PM 2.5 injection. The results showed acute health effects from directly injected PM 2.5 , including rapid inflammation, oxidative damage, and routine-behavioral changes. Further study about the long-term effects of injection and the immune defense is warranted. Nonetheless, the results here suggest that PM 2.5 health effects may have to some extent been exaggerated in the literature.

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Proinflammatory and anti-inflammatory cytokines in adolescents from Southeast Bulgarian cities with different levels of air pollution

Cited by 42 publications

References 24 publications

Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Exposure to traffic-related air pollution and serum inflammatory cytokines in children

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children

PM2.5 Meets Blood: In vivo Damages and Immune Defense

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