Proinflammatory Cytokines and Chemokines as Biomarkers of Persistent Arthralgia and Severe Disease After Chikungunya Virus Infection: A 5-Year Follow-Up Study in Southern Thailand

Ninla-aesong, Putrada; Mitarnun, Winyou; Noipha, Kusumarn

doi:10.1089/vim.2019.0064

Cited by 31 publications

(21 citation statements)

References 50 publications

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“…Levels of TNF-α, matrix metalloproteinase (MMP)-1 and MMP-3 were significantly increased in patients with persistent arthralgia compared with those in fully recovered patients. A greater reduction in RANTES levels was observed in patients with severe pain than in patients with non-severe pain, whereas the increases in IFN-γ, IL-1β, IL-6, and IL-8 levels were more marked in patients with severe pain [23].…”

Section: Secreted Cytokines and Chemokines And Severity Of Chikv Infementioning

confidence: 80%

“…In contrast, lower IL-8 levels were observed in severe-CHIKV infection groups than in mild-CHIKV infection groups [17]. In addition to IL-8, the levels of RANTES proteins were found to decrease in patients with severe pain [23]. However, elevated levels of RANTES proteins were observed in the synovial fluids, plasma, and tissues of RA patients [38,39].…”

Section: Il-17amentioning

confidence: 92%

“…Associated with swollen joint counts [22] TNF-α, MMP-1 MMP-3 Higher in patients with persistent arthralgia than in fully recovered patients [23] RANTES Lower in patients with severe pain than in patients with non-severe pain [23] IFN-γ, IL-1β, IL-6, IL-8 Higher in patients with severe pain than in patients with non-severe pain [23] IL-6, GM-CSF Associated with persistent arthralgia [26] Cynomolgus macaques infected with CHIKV demonstrate similar features to human patients. It has been shown in this animal model that CHIKV antigen could be detected in various tissues up to 3 months post-infection.…”

Section: Il-17amentioning

confidence: 99%

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Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

2020

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Chikungunya virus (CHIKV) infection has been commonly detected in tropical countries. The clinical manifestations of CHIKV infection are similar to those of rheumatoid arthritis. Outbreaks of CHIKV infection in Thailand have been reported, and the inductions of various cytokines and chemokines in CHIKV patients during those outbreaks have been shown. Although immune responses in CHIKV infection have been increasingly reported, the mechanisms associated with pathology induction are still not clearly understood. This review focuses on cytokine and chemokine production in CHIKV infection, in association with the severity of joint inflammation. Several cytokines and chemokines involved in the induction or regulation of inflammatory responses were shown to associate with the severe and persistent symptoms in CHIKV infection. Further studies on the difference in immune responses observed in an autoimmune disease, rheumatoid arthritis, infectious disease, and CHIKV infection, would provide additional insights useful for proper CHIKV therapy, especially in patients with severe joint pains.

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Section: Secreted Cytokines and Chemokines And Severity Of Chikv Infementioning

confidence: 80%

Section: Il-17amentioning

confidence: 92%

Section: Il-17amentioning

confidence: 99%

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Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

2020

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“…Several other studies have reported elevated serum CXCL8 levels in the acute phase compared to healthy controls (35,37,38), and an even greater increase in levels of this chemokine in the chronic phase of the disease compared to the acute phase (39). Furthermore, CXCL8 has also been detected in serum (40) and synovial fluid (14, 41) of patients with chronic arthralgia after CHIKV infection. On the other hand, some studies found that reduced levels of CXCL8 were associated with increased intensity of pain (42) and chronic arthralgia (43).…”

Section: Discussionmentioning

confidence: 89%

Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection

et al. 2021

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The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.

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“…This triggers a potent inflammatory response driven by type I Interferon (IFN), resulting in a large influx of infiltrating cells and production of antiviral and proinflammatory cytokines and chemokines. Elevated levels of IFN-γ, IL-1β, IL-6, CCL2, CXCL9 and CXCL10 have been detected during CHIKV infection (Ninla-aesong et al, 2019). Production of these cytokines recruits monocytes, macrophages, NK cells, and T cells to site of infection, which contribute to tissue injury and disease (Gardner et al, 2010).…”

Section: Chikv Pathogenesismentioning

confidence: 99%

Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals

Bakar¹

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Proinflammatory Cytokines and Chemokines as Biomarkers of Persistent Arthralgia and Severe Disease After Chikungunya Virus Infection: A 5-Year Follow-Up Study in Southern Thailand

Cited by 31 publications

References 50 publications

Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection

Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals

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