Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis

Javed, Fawad; Al‐Hezaimi, Khalid; Salameh, Ziad; Almas, Khalid; Romanos, Georgios E.

doi:10.1016/j.cyto.2010.08.013

Cited by 118 publications

(105 citation statements)

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“…10,11 Increased levels of these cytokines in the oral fluids have been associated with the etiology of periodontal and peri-implant diseases. [21][22][23] Interestingly, our results showed no statistically significant difference in peri-implant PD, BOP, PI, and mesial and distal CBL around short implants placed in both groups. It is however imperative to interpret these results with caution as a number of factors seem to have influenced the reported results.…”

Section: Discussionmentioning

confidence: 56%

Comparison of peri‐implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette‐smokers and never‐smokers: Six‐year follow‐up results

Abduljabbar

Al-Hamoudi

Al-Sowygh

et al. 2017

Clin Implant Dent Rel Res

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Background: It is hypothesized that peri-implant clinical and radiographic inflammatory parameters (probing depth [PD], bleeding on probing [BOP] and plaque index [PI]; and radiographic (crestal bone loss [CBL]) are worse among cigarette-smokers (CS) compared with never-smokers (NS) with short implants.Purpose: The present 6-year follow-up retrospective study compared the peri-implant clinical and radiographic parameters in CS and NS with short dental implants (6 mm in length). Materials and methods:Fifty-six male individuals were included. These individuals divided into 2 groups as follows: (a) Group-1: 29 self-reported systemically healthy CS with 48 short-implants; and (b) Group-2: 27 self-reported systemically healthy NS with 43 short implants. Peri-implant PD, PI, BOP, and CBL were measured. Group comparisons were done using the Kruskal-Wallis test and sample size was estimated. Level of significance was set at P values < .05. Results:In groups 1 and 2, the follow-up durations were 6.2 6 0.1 years and 6.1 6 0.3 years, respectively. A cigarette smoking history of 8.9 6 3.6 pack years was reported by individuals in Group-1. At follow-up, scores of peri-implant PD, BOP, PI, and mesial and distal CBL were comparable around short implants in both groups. Conclusion:Under strict oral hygiene maintenance protocols, short dental implants can remain functionally stable in CS in a manner similar to NS.

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Section: Discussionmentioning

confidence: 56%

Comparison of peri‐implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette‐smokers and never‐smokers: Six‐year follow‐up results

Abduljabbar

Al-Hamoudi

Al-Sowygh

et al. 2017

Clin Implant Dent Rel Res

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“…17, 25 Strikingly, IL‐6 and FGF‐2 showed a significant downregulation in mRNA expression. Depending on the micro‐environment IL‐6 can have a pro‐inflammatory or anti‐inflammatory properties with a large inter‐individual variability 26.…”

Section: Discussionmentioning

confidence: 96%

Cytokine expression profile in the bone‐anchored hearing system: 12‐week results from a prospective randomized, controlled study

Calon

Tongeren

Omar

et al. 2018

Clin Implant Dent Rel Res

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ObjectiveTo study the effect of implanting the percutaneous bone‐anchored hearing system (BAHS) itself and inflammation of the peri‐abutment skin warrant clarification. In this study, we aimed to acquire further insight into the immune responses related to BAHS surgery and peri‐implant skin inflammation.Materials and MethodsDuring surgery and 12 weeks post‐implantation, skin biopsies were obtained. If applicable, additional biopsies were taken during cases of inflammation. The mRNA expression of IL‐1β, IL‐6, IL‐8, TNFα, IL‐17, IL‐10, TGF‐ß, MIP‐1α, MMP‐9, TIMP‐1, COL1α1, VEGF‐A, FGF‐2 TLR‐2, and TLR‐4 was quantified using qRT‐PCR.ResultsThirty‐five patients agreed to the surgery and 12‐week biopsy. Twenty‐two patients had mRNA of sufficient quality for analysis. Ten were fitted with a BAHS using the minimally invasive Ponto surgery technique. Twelve were fitted with a BAHS using the linear incision technique with soft‐tissue preservation. Five biopsies were obtained during episodes of inflammation. The post‐implantation mRNA expression of IL‐1β (P = .002), IL‐8 (P = .003), MMP9 (P = .005), TIMP‐1 (P = .002), and COL1α1 (P < .001) was significantly up‐regulated. IL‐6 (P = .009) and FGF‐2 (P = .004) mRNA expression was significantly down‐regulated after implantation. Within patients, no difference between post‐implantation mRNA expression (at 12 weeks) and when inflammation was observed. Between patients, the expression of IL‐1β (P = .015) and IL‐17 (P = .02) was higher during cases of inflammation compared with patients who had no inflammation at 12‐week follow‐up.ConclusionsAs part of a randomized, prospective, clinical trial, the present study reports the molecular profile of selected cytokines in the soft tissue around BAHS. Within the limit of this study, the results showed that 12 weeks after BAHS implantation the gene expression of some inflammatory cytokines (IL‐8 and IL‐1β) is still relatively high compared with the baseline, steady‐state, expression. The up‐regulation of anabolic (COL1α1) and tissue‐remodeling (MMP‐9 and TIMP1) genes indicates an ongoing remodeling process after 12 weeks of implantation. The results suggest that IL‐1β, IL‐17, and TNF‐α may be interesting markers associated with inflammation.

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“…Por esta razón, el diagnóstico, tratamiento y seguimiento de la PAA actualmente representan un desafío clínico. Dentro de las citoquinas involucradas en la patogénesis de estas lesiones, TNFse ha investigado en el presente estudio dados sus potentes efectos proinflamatorios, su rol clave durante la diferenciación y activación de los osteoclastos, así como por su fuerte asociación con el desarrollo y severidad de otras patologías inflamatorias crónicas, que del mismo modo que las PAA, cursan con lesiones osteolíticas como resultado de la infección de los tejido afectados (14)(15)(16) . En el presente estudio se demostró la presencia de cambios en los niveles de TNF-en FCG de dientes con PAA.…”

Section: Discussionunclassified

Asociación entre niveles de TNF-α en fluido crevicular gingival de dientes con periodontitis apical asintomática

Flores

Vitali

Cabrera

et al. 2011

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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RESUMENIntroducción: Como consecuencia de necrosis pulpar séptica, el ingreso de productos bacterianos en el periápice induce la producción de citoquinas pro-inflamatorias como el Factor de Necrosis Tumoral (TNF)-, que entre otras funciones participa en la diferenciación y activación de los osteoclastos para inducir reabsorción ósea, fenómeno característico de la periodontitis apical asintomática (PAA). El fluido crevicular gingival (FCG) ofrece un gran potencial como fuente de factores asociados con la actividad osteoclástica. El objetivo del presente estudio fue determinar los niveles de TNFen FCG de dientes con PAA y controles sanos contralaterales. Métodos: Se incluyeron 14 pacientes en la Clínica de Endodoncia de la Facultad de Odontología de la Universidad de Chile con diagnóstico clínico de PAA y se obtuvieron muestras de FCG con tiras de papel a partir de los dientes afectados y sanos contralaterales por un periodo estandarizado de 30 segundos. Se determinaron las concentraciones de proteínas totales mediante el método del ácido bisciconitico y los niveles de TNF-, mediante ensayo ELISA. Los datos se analizaron con Test-t pareado utilizando el programa StataV11. Resultados: Se detectaron niveles de TNF-significativamente mayores en el FCG de dientes con PAA estandarizados, tanto por 30 segundos de toma de muestra como por mg de proteínas totales. Conclusiones: Este estudio provee evidencia preliminar de que los niveles de TNF-en el FCG reflejan la presencia de PAA y podría ser de utilidad como complemento al diagnóstico clínico y monitoreo del estado de salud o enfermedad de los tejidos perirradiculares. ABSTRACT Introduction: As a consequence of septic pulp necrosis, the entry of bacterial products into periapical tissues induces the release of pro-inflammatory cytokines, such as the tumor necrosis factor (TNF)-. This pleiotropic cytokine is involved in the differentiation and activation of osteoclasts to induce bone resorption, a hallmark of asymptomatic apical periodontitis (AAP). Gingival crevicular fluid (GCF) has a great potential as a source of factors associated with osteoclastic activity. The aim of this study was to determine the levels of TNF-in GCF of teeth with PAA and contralateral healthy controls. Methods: A total of 14 patients with clinical diagnosis of AAP were enrolled from the Clinic of Endodontics, Faculty of Dentistry, Universidad de Chile during 2009 and 30-second GCF samples were obtained with paper strips from AAP teeth and contralateral healthy controls. Total protein concentration and TNF-levels were determined through bisciconitic acid method and ELISA assay, respectively. Paired t test and StataV11 software were used for statistical analysis. Results: Levels of TNF-were significantly higher in GCF from teeth with AAP than controls when standardized by either 30s of sampling and total protein content. Conclusions: The present study provides preliminary data supporting that TNF-levels in GCF reflect periapical status. Screening of TNF-levels in GCF might represent a useful sid...

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Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis

Cited by 118 publications

References 35 publications

Comparison of peri‐implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette‐smokers and never‐smokers: Six‐year follow‐up results

Comparison of peri‐implant clinical and radiographic status around short (6 mm in length) dental implants placed in cigarette‐smokers and never‐smokers: Six‐year follow‐up results

Cytokine expression profile in the bone‐anchored hearing system: 12‐week results from a prospective randomized, controlled study

Asociación entre niveles de TNF-α en fluido crevicular gingival de dientes con periodontitis apical asintomática

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