Proinflammatory Cytokines in the Saliva, Gingival Crevicular Fluid and Serum of Diabetic Patients with Periodontal Disease

Javed, Fawad; Ahmed, Asma

doi:10.5171/2013.956990

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…In this study, IL-1β was examined randomly among Type 1 diabetes mellitus, Type 2 diabetes mellitus and ketoacidotic patients. Plasma levels of IL-1β in patients submitted were higher than control group which is a similar finding to that reported by Javed and Ahmed (2013). In the present study, the mean plasma level of IL-1β was nearly three, seven and five times the control group value in Type 1 diabetes mellitus, ketoacidotic and Type 2 diabetes mellitus patients, respectively.…”

Section: (55%)supporting

confidence: 91%

Effect of diabetes on occurrence of urinary tract infection and asymptomatic bacteriuria among diabetic and ketacidosis patients in Egypt

Adly¹,

Ragab²,

Hashem³

et al. 2015

Int. Res. J. Microbiol

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Diabetic patients have a higher risk of infections which is the leading trigger of diabetic ketoacidosis. The second most common infection in diabetics is urinary tract infection (UTI). Elevation of glucose level induces an inflammatory process within numerous tissues in the body leading to disturbance in cytokines level and oxidative stress. This study is divided into two parts, firstly it was to investigate the prevalence of asymptomatic bacteriuria (ASB) and urinary tract infections in 84 Type 1 diabetes patients, 63 Type 2 diabetes patients and 57 ketoacidotic patients, and to determine the uropathogens responsible for ASB and UTIs as well as their antimicrobial susceptibility pattern. The second part is to determine the level of IL-1β, IL-6 and superoxide dismutase (SOD) in blood samples of diabetic and ketoacidotic patients. Escherichia coli was the most common isolated bacterial uropathogen followed by Enterococcus faecalis, Staphylococcus saprophyticus and Pseudomonas aeruginosa. These isolates showed 100% sensitivity to cephalothin, imipenem, linezolid, teicoplanin, ceftobiprole and piperacillin-tazobactam. Upon examining cytokines level in diabetic patients, results showed higher levels of IL-1β and IL-6 than control samples, indicating inflammation and disturbance in the regulation of metabolic, regenerative, and neural processes, while SOD examination showed lower levels than control samples, indicating both micro-and macrovascular diabetic complications.

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Section: (55%)supporting

confidence: 91%

Effect of diabetes on occurrence of urinary tract infection and asymptomatic bacteriuria among diabetic and ketacidosis patients in Egypt

Adly¹,

Ragab²,

Hashem³

et al. 2015

Int. Res. J. Microbiol

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show abstract

“…The study of Dambala et al in 2017 also showed the same result (43). In the study of Javed et al (2913), the level of MMP-8 was higher in the saliva and serum of patients with PCOS and periodontal disease compared to the control group (comprised of women who were systemically healthy and had healthy gums) (16). However, the results of studies are contradictory (44)(45)(46).…”

Section: Discussionmentioning

confidence: 82%

“…This process is resulted from the imbalance between the periodontal pathogens and the host response (16).…”

Section: Introductionmentioning

confidence: 99%

Assessment of gingival inflammation indexes and matrix metalloproteinase (MMP-9) in patients with polycystic ovarian syndrome compared to control group

Maboudi¹,

Shafizade²,

Amiri³

et al. 2020

Preprint

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Background: There is emerging evidence to support the link between polycystic ovarian syndrome (PCOS) and periodontal disease, but the mechanisms associated with these two diseases have not been clearly elucidated but relate to different aspects of inflammation. This study aimed to determine the gingival inflammation indexes and matrix metalloproteinase-9 (MMP-9) in patients with polycystic ovarian syndrome compared to control group.Methods: This is a case-control study in which 87 women referred to the Babol Clinic Private Hospital were divided into three groups: 26 women with PCOS diagnosed on the basis of Rotterdam criteria with gingivitis, 26 women with PCOS without gingivitis and 26 healthy women who were matched for age and body mass index. After recording the underlying variables, fasting saliva samples were taken from all participants in the morning before any periodontal intervention. The samples, which were transferred to Babol Molecular Cell Research Center under cold-chain conditions to measure the serum levels of MMP-9 using ELISA kits. Periodontal status was evaluated for Gingival index (GI), bleeding on probing (BOP), plaque index (PI). Analysis of variance was used to compare the results for the normal quantitative variables and Chi-square test was used to compare the qualitative variables. Significance level was considered less than 0.05.Results: The highest mean periodontal disease indexes (GI, BOP, PI) were observed in women with PCOS with gingivitis and then in women with PCOS without gingivitis and then in healthy women in control group (p <0.05). The mean salivary MMP-9 levels were significantly higher in PCOS women (388/37 ± 75.05) compared to the control group (166/25 ± 35/43). Even in PCOS patients with healthy gingiva (233.00± 47.76) had higher levels of salivary MMP-9 than the control group and this difference was significant (p <0.05)Conclusions: There is a positive association between periodontal disease and PCOS and that salivary MMP-9 levels are higher in PCOS women with and without gingivitis than healthy women. However, it is recommended that multicenter study with larger sample sizes are to be conducted to establish a clearer association.

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“…In the present study, although all the readings of MMP-9 fall within the normal reference range, they were higher in women with PCOS regardless of their gingival status compared to women from the control group. The possible linkage between MMP-9 and PCOS pathogenesis is that the rate of growth and regeneration of ovarian follicles is modified by the balance between MMPs in the extracellular environment [23], which may explain the higher levels seen in women with PCOS compared to women in the control group in some studies [24][25][26]. Other studies provided contradictory results [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Salivary Matrix Metalloproteinase-9 in Women With Polycystic Ovaries Syndrome and Gingival Inflammation: A Case-Control Study

Maboudi¹,

Amiri²,

Shafizade³

et al. 2023

Cureus

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BackgroundPolycystic ovary syndrome (PCOS) is an endocrine disease of women of reproductive age that impacts their oral and systemic well-being. This study aimed to compare the gingival inflammation indices and matrix metalloproteinase-9 (MMP-9) of non-obese women with PCOS. Materials and methodsThis is a case-control study in which 78 women were referred to the Babol Clinic Hospital in Northern Iran between 2018 and 2019. They were divided into three groups: 26 women with PCOS and gingivitis, 26 women with PCOS with no gingivitis, and 26 women with no PCOS and no gingivitis as a control group. After recording the anthropometric and demographic variables, fasting saliva samples were taken from all participants before any periodontal intervention. These samples were transferred to Babol Molecular Cell Research Center under highly guaranteed cold-chain conditions to measure the serum levels of MMP-9. Periodontal status was evaluated for Gingival Index (GI), Plaque Index (PI), and Bleeding on Probing (BOP). Analysis of variance was used to compare the mean results for these indices. The significance level was considered when p ≤ 0.05. ResultsAll the gingival indices were significantly higher for women with PCOS with gingivitis compared to the results for women from the other two groups. Similarly, women with PCOS showed high salivary MMP-9 levels but were within the normal reference ranges. ConclusionThe gingival indices (GI, PI, and BOP) and salivary MMP-9 are higher in women with PCOS, regardless of the gingival status.

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Proinflammatory Cytokines in the Saliva, Gingival Crevicular Fluid and Serum of Diabetic Patients with Periodontal Disease

Cited by 4 publications

References 43 publications

Effect of diabetes on occurrence of urinary tract infection and asymptomatic bacteriuria among diabetic and ketacidosis patients in Egypt

Effect of diabetes on occurrence of urinary tract infection and asymptomatic bacteriuria among diabetic and ketacidosis patients in Egypt

Assessment of gingival inflammation indexes and matrix metalloproteinase (MMP-9) in patients with polycystic ovarian syndrome compared to control group

Evaluation of the Salivary Matrix Metalloproteinase-9 in Women With Polycystic Ovaries Syndrome and Gingival Inflammation: A Case-Control Study

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