Proinflammatory Properties of Coplanar PCBs: In Vitro and in Vivo Evidence

Hennig, Bernhard; Purushothaman, Meerarani; Slim, Rabih; Toborek, Michał; Daugherty, Alan; Silverstone, Allen E.; Robertson, Larry W.

doi:10.1006/taap.2002.9408

Cited by 227 publications

(192 citation statements)

References 51 publications

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“…This mechanism is also supported by the results of population-based studies [30][31][32]. POPs also contribute to other known mechanisms of the development of atherosclerosis; they induce an inflammatory process [33], cause dysfunction of the vascular endothelium [34,35], and stimulate the differentiation of macrophages into foam cells [36]. The major potential confounders of concern in this epidemiological study are race, age, gender, and socio-economic status (SES).…”

Section: Discussionsupporting

confidence: 62%

Residential proximity to environmental sources of persistent organic pollutants and first-time hospitalizations for myocardial infarction with comorbid diabetes mellitus: a 12-year population-based study

Сергеев¹,

Carpenter²

2010

International Journal of Occupational Medicine and Environmental Health

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Objectives: Environmental exposure to persistent organic pollutants (POPs) has been associated with an increased risk of both acute myocardial infarction (AMI) and diabetes mellitus (DM). A study of first-time hospitalizations for AMI with DM as a comorbidity in populations presumed to be exposed or not exposed on the basis of residence near POPs sites was conducted to investigate whether exposure to POPs increases the environmental burden of disease. Materials and Methods: We examined the association between residential proximity to environmental sources of POPs and hospitalization rates for first-time AMI with comorbid DM in 31 428 patients aged 25-74 years, using the New York Statewide Planning and Research Cooperative System data for a 12-year period (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004). Environmental exposure status was assessed based on the zip code of residence. Adjusted relative risks (RR) of AMI hospitalization were estimated by multivariate Poisson regression. Results: Hospitalization rates for first-time AMI with comorbid DM were significantly greater in populations living near POPs sites (adjusted RR = 1.169, 95% CI: 1.014-1.347, p < 0.05). These rates were also significantly higher in African Americans than in Caucasians (adjusted RR = 1.902, 95% CI: 1.659-2.180, p < 0.001), in males (adjusted RR = 1.767, 95% CI: 1.695-1.843, p < 0.001), and for older ages (p for trend < 0.001). These findings, consistent with established non-modifiable risk factors, support the plausibility of our model. Conclusions: Residential proximity to environmental sources of POPs is associated with a significant increase in hospitalization rates for first-time AMI with comorbid DM, compared to respective rates in populations not exposed to POPs.

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Section: Discussionsupporting

confidence: 62%

Residential proximity to environmental sources of persistent organic pollutants and first-time hospitalizations for myocardial infarction with comorbid diabetes mellitus: a 12-year population-based study

Сергеев¹,

Carpenter²

2010

International Journal of Occupational Medicine and Environmental Health

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“…Another important role in the pathogenesis is an increase in oxidative stress. Several studies have indicated that PCB mediates endothelial cell dysfunction by activating oxidative stress-sensitive signaling pathways and inducing subsequent proinflammatory events critical to the development of cardiovascular disease and atherosclerosis [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: Results from the National Health and Nutrition Examination Survey 1999–2004

et al. 2011

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“…In the present study, we found that TCDD treatment enhanced MCP-1 expression, and Aroclor1254 and TCDD co-exposure enhanced the up-regulation of MCP-1, suggesting a combined influence in promoting the expression of this chemoattractant. Our and other lab's previous studies demonstrated that PCB77 and PCB104 increased the expression of IL-6 and E-selectin in endothelial cells, respectively (Hennig et al, 2002;Choi et al, 2003;Hennig et al, 2005). However, PCB77 and TCDD were also shown no effects on IL-6 expression in 3T3-L1 cell in other studies (Arsenescu et al, 2008).…”

Section: Discussionmentioning

confidence: 50%

Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin

Shan

Wang

Huang

et al. 2014

Toxicology and Applied Pharmacology

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Keywords:PCBs TCDD Atherosclerosis PF4 MCP-1 RIG-I 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants found as complex mixtures in the environment throughout the world. Therefore, humans are ubiquitously and simultaneously exposed to TCDD and PCBs. TCDD and PCBs alone have been linked to atherosclerosis. However, the effects of interactions or synergism between TCDD and PCBs on atherogenesis are unknown. We investigated the possible enhanced atherogenesis by co-exposure to TCDD and PCBs and the potential mechanism(s) involved in this enhancement. Male ApoE −/− mice were exposed to TCDD (15 μg/kg) and Aroclor1254 (55 mg/kg, a representative mixture of PCBs) alone or in combination by intraperitoneal injection four times over six weeks of duration. Our results showed that mice exposed to TCDD alone, but not Aroclor1254 alone, developed atherosclerotic lesions. Moreover, we found that atherosclerotic disease was exacerbated to the greatest extent in mice co-exposed to TCDD and Aroclor1254. The enhanced lesions correlated with several proatherogenic changes, including a marked increase in the accumulation of the platelet-derived chemokine PF4, and the expression of the proinflammatory cytokine MCP-1 and the critical immunity gene-RIG-I. Our data demonstrated that co-exposure to TCDD and Aroclor1254 markedly enhanced atherogenesis in ApoE −/− mice. Significantly, our observations suggest that combined exposure to TCDD and PCBs may be a greater cardiovascular health risk than previously anticipated from individual studies.

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Proinflammatory Properties of Coplanar PCBs: In Vitro and in Vivo Evidence

Cited by 227 publications

References 51 publications

Residential proximity to environmental sources of persistent organic pollutants and first-time hospitalizations for myocardial infarction with comorbid diabetes mellitus: a 12-year population-based study

Residential proximity to environmental sources of persistent organic pollutants and first-time hospitalizations for myocardial infarction with comorbid diabetes mellitus: a 12-year population-based study

Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: Results from the National Health and Nutrition Examination Survey 1999–2004

Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin

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