2015
DOI: 10.4049/jimmunol.1401038
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Proinflammatory Responses and Higher IL-10 Production by T Cells Correlate with Protection against Malaria during Pregnancy and Delivery Outcomes

Abstract: Pregnancy triggers immunological changes aimed to tolerate the fetus. However, it has not been properly addressed whether similar changes occur in tropical areas with high infection pressure and whether these changes render women more susceptible to infectious diseases. We compared the frequencies of T cell subsets, including regulatory T cells, in pregnant and nonpregnant women from Papua New Guinea, a high malaria transmission area, and from Spain, a malaria-free country. We also assessed the relationship am… Show more

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Cited by 21 publications
(24 citation statements)
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“…There are several studies on immune activation and inflammation during P. falciparum infection, and some of these have also examined T-cells, monocytes/macrophages and neutrophils [9][10][11][12], but the role of these cells during falciparum malaria are far from clear. In particular, most studies have focused on one of these cell subsets, and fewer have examined the activation pattern of these cells simultaneously.…”
Section: Introductionmentioning
confidence: 99%
“…There are several studies on immune activation and inflammation during P. falciparum infection, and some of these have also examined T-cells, monocytes/macrophages and neutrophils [9][10][11][12], but the role of these cells during falciparum malaria are far from clear. In particular, most studies have focused on one of these cell subsets, and fewer have examined the activation pattern of these cells simultaneously.…”
Section: Introductionmentioning
confidence: 99%
“…The second finding from prospective analyses concerned elevated non-specific TNF responses at inclusion that were a prognostic marker for subsequent infections. This observation is clearly incompatible with the purported protective role against infection detected at delivery attributed to non-specific proinflammatory responses measured at recruitment in a cohort of Papua New Guinean women [ 27 ]. Whether or not, in the context of the latter study, (i) the timing of recruitment and/or (ii) lifelong exposure to both P. vivax and P. falciparum have any bearing on this issue remain open questions.…”
Section: Discussionmentioning
confidence: 86%
“…Pregnancy has been described as an immunomodulated state during which both anti-inflammatory cytokines (IL-4 IL-5 and IL-13) and pro-inflammatory cytokines (TNF-α, IFN-γ, and IL-6) are elevated [ 31 – 34 ]. These changes are believed to play a critical role for successful pregnancy, and cytokine balance remains paramount during pregnancy, as excessive inflammatory cytokines may jeopardize the pregnancy [ 35 37 ]. This regulation is mediated in part by the anti-inflammatory cytokine, IL-10.…”
Section: Discussionmentioning
confidence: 99%