“…Those in urban centers are especially at risk of negative sexual outcomes for multiple reasons, including greater exposure to sexually transmitted infections (STIs) [ 14 , 15 ]. Black youth residing in urban areas typically reflect lower rates of substance use and co-occurring sexual activity compared to their White peers; however, they experience poorer health outcomes, including elevated rates of contracting HIV and STIs [ 16 , 17 , 18 , 19 , 20 , 21 ]. While drug use rates among Black youth are lower than those among other racial groups, Black youth who use drugs tend to have worse health outcomes and negative consequences associated with drug use, such as suspension from school, involvement in the (juvenile) criminal justice system, and poor sexual health outcomes [ 22 , 23 ].…”