This study explores the effects of adaptive leadership practices on organizational effectiveness and the link and prediction of both constructs in higher education institutions located in the Amhara National Regional State of Ethiopia. The study adopted a descriptive survey and correlational research design with a quantitative method. The target population of the study consists of 5460 deans, directors, and academic staff members. The sample size was determined to be 620 using a sample size determination formula. A questionnaire with multi-item scales from prior developed models was adapted to gather primary data. Percentages, mean values, one-sample t-test, correlation, and regression analysis were used to examine the data. The findings revealed that leaders practice adaptive leadership at every level because of the current uncertain and dynamic challenges confronting institutions. Furthermore, leadership practice, characterized by adaptation and knowledge building, has led institutions to be effective organizations. The findings also indicate that the constructs have a positive and substantial association. This suggests that the more adaptive leadership is practiced in the institutions under investigation, the higher the goal attainment and organizational effectiveness will be.