Project YES! Youth Engaging for Success: A randomized controlled trial assessing the impact of a clinic-based peer mentoring program on viral suppression, adherence and internalized stigma among HIV-positive youth (15-24 years) in Ndola, Zambia

Denison, Julie A.; Burke, Virginia M.; Miti, Sam; Nonyane, Bareng A. S.; Frimpong, Christiana; Merrill, Katherine G.; Abrams, Elizabeth A.; Mwansa, Jonathan K.

doi:10.1371/journal.pone.0230703

Cited by 59 publications

(78 citation statements)

References 38 publications

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“…Analyses used cross-sectional baseline data from Project YES! (Youth Engaging for Success), a randomized controlled trial among youth living with HIV attending four clinics in Ndola, Zambia [ 27 , 28 ]. The trial compared an intervention and comparison group to assess the effects of a peer-mentoring intervention on youths’ VL suppression (< 1000 copies/mL), ART treatment adherence (gap of 48 or more consecutive hours), and internalized/self-stigma [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Past-Year Violence Victimization is Associated with Viral Load Failure Among HIV-Positive Adolescents and Young Adults

et al. 2020

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We examined the relationship between past-year violence victimization and viral load (VL) failure among consecutively-sampled male and female adolescents and young adults, aged 15–24, in four HIV clinics in Ndola, Zambia. Measures of past-year physical violence, psychological abuse, and forced sex were adapted from the ICAST-C and WHO Multi-Country Study. Using logistic regression, we derived associations between VL failure (≥ 1000 copies/mL) and: any victimization; cumulative victimization; and types and perpetrators of violence. Among 272 youth (59.2% female, 72.8% perinatally infected), 73.5% (n = 200) experienced past-year violence and 36.8% (n = 100) had VL failure. Higher odds of VL failure were observed for participants who reported high frequency of any violence versus no violence victimization (adjusted OR, aOR: 3.58; 95% CI 1.14–11.27), high frequency of psychological abuse versus no psychological abuse (aOR: 3.32; 95% CI 1.26–8.70), any versus no violence from a family member other than a parent/caregiver for physical violence (aOR: 2.18, 95% CI 1.05–4.54) and psychological abuse (aOR: 2.50; 95% CI 1.37–4.54), and any versus no physical violence from a friend/peer (aOR: 2.14, 95% CI 1.05–4.36). Past-year violence victimization was associated with VL failure when considering the frequency, type, and perpetrator of violence. Programs addressing violence among youth living with HIV may be critical to improving viral suppression and preventing onward transmission.

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Section: Introductionmentioning

confidence: 99%

Past-Year Violence Victimization is Associated with Viral Load Failure Among HIV-Positive Adolescents and Young Adults

et al. 2020

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“…Peer support groups have significant potential to support ALHIV during this time. [25][26][27][28] Recent evidence supports the idea of peer support as an essential component of interventions for ALHIV, including retention in care. 25,26 Specifically, peer support can address day-to-day challenges of being an ALHIV, such as remembering when to take treatment and to attend clinic appointments.…”

Section: Discussionmentioning

confidence: 99%

“…24 Recent studies highlight the potentially beneficial uses of peer support groups for ALHIV health. [25][26][27][28] The Zvandiri project in Zimbabwe, which integrated peer-led community interventions into adolescent health service delivery, reported improvements in adolescent and child adherence and retention in care. 25 Peer support can also facilitate retention in care for ALHIV.…”

Section: Introductionmentioning

confidence: 99%

“Those People Motivate and Inspire Me to Take My Treatment.” Peer Support for Adolescents Living With HIV in Cape Town, South Africa

Rencken

Harrison

Mtukushe

et al. 2021

J Int Assoc Provid AIDS Care

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Adherence to antiretroviral therapy (ART) and psychosocial support to manage stigma and disclosure is essential for adolescents living with HIV (ALHIV). Peer support groups can help ALHIV and their families live successfully with HIV. This qualitative study aimed to examine adolescent and caregiver perspectives on peer support groups. Three themes emerged: (1) peer support encouraged adherence to ART, (2) serostatus disclosure outside the family was perceived as difficult, and (3) the peer support group fostered fundamental and meaningful peer relationships for ALHIV. Caregivers felt peer support groups increased self-acceptance and adherence for ALHIV across 3 domains: (1) as motivation for families and adolescents, (2) to increase adolescent independence and maturity, and (3) to help adolescents accept their HIV status and live successfully with HIV. These data highlight the importance of psychosocial support groups for ALHIV and caregivers, illustrating the benefits of a safe space with trusted relationships and open communication.

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“…Project YES! study methods are described in detail elsewhere (ClinicalTrials.gov NCT04115813) [23]. In brief, key study eligibility criteria included being between 15-24 years of age, on ART for at least 6 months, aware of one's HIV-positive status, and willing to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia

Miti¹,

Handema

Mulenga

et al. 2020

PLoS ONE

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Background HIV drug resistance (HIVDR) poses a threat to the HIV epidemic control in Zambia especially in sub-populations such as the 15-24 years where there is poor virological suppression. Understanding the prevalence and patterns of HIVDR in this population (15-24 years) will contribute to defining effective antiretroviral therapy (ART) regimens, improving clinical decision making, and supporting behavioral change interventions needed to achieve HIV epidemic control. Methods A cross-sectional analysis of study enrollment data from the Project YES! Youth Engaging for Success randomized controlled trial was conducted. Participants were 15 to 24 years old, who knew their HIV status, and had been on ART for at least 6 months. All participants completed a survey and underwent viral load (VL) testing. Participants with viral failure (VL �1,000 copies/mL) underwent HIVDR testing which included analysis of mutations in the protease and reverse transcriptase genes. Results A total of 99 out of 273 analyzed participants receiving ART had VL failure, of whom 77 had successful HIVDR amplification and analysis. Out of the 77, 75% (58) had at least one drug resistant mutation, among which 83% (48/58) required a drug change. Among the 58 with HIVDR mutations, the prevalence of at least one HIVDR mutation to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs)

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Project YES! Youth Engaging for Success: A randomized controlled trial assessing the impact of a clinic-based peer mentoring program on viral suppression, adherence and internalized stigma among HIV-positive youth (15-24 years) in Ndola, Zambia

Cited by 59 publications

References 38 publications

Past-Year Violence Victimization is Associated with Viral Load Failure Among HIV-Positive Adolescents and Young Adults

Past-Year Violence Victimization is Associated with Viral Load Failure Among HIV-Positive Adolescents and Young Adults

“Those People Motivate and Inspire Me to Take My Treatment.” Peer Support for Adolescents Living With HIV in Cape Town, South Africa

Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia

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