Projection-Resolved Optical Coherence Tomographic Angiography of Retinal Plexuses in Retinitis Pigmentosa

Hagag, Ahmed M; Wang, Jie; Lu, Kevin; Harman, Gareth; Weleber, Richard G.; Huang, David; Yang, Paul; Pennesi, Mark E.; Jia, Yali

doi:10.1016/j.ajo.2019.02.034

Cited by 32 publications

(32 citation statements)

References 64 publications

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“…In comparison, Hagag et al found reductions in vessel density in the perifoveal deep retinal plexus (ICP and DCP), but not in the superficial vascular complex (SVC), in RP eyes [36]. They also demonstrated a significant correlation between outer retinal thickness with intermediate capillary plexus (ICP) as well as DCP vessel density, but not in the SVC, in eyes without cystoid macular edema (CME) [36].…”

Section: Octa In Retinitis Pigmentosamentioning

confidence: 98%

“…As explained by the authors, one of the possible reasons for the difference between their results and other published studies is that the commercial software used in most other studies faultily places the ICP with the superficial plexus slab. In contrast, Hagag and coauthors used a reflectance based projection resolved OCTA algorithm, that suppressed projection artifacts and divided retinal vasculature into three distinct layers in the macula [36]. Interestingly, an earlier qualitative study by Rezaei and colleagues examining 25 eyes from 13 RP patients with varying degrees of visual field loss reported that eyes with central visual field less than 30 degrees demonstrated abnormal microvasculature in the deep retinal and choriocapillaris layers.…”

Section: Octa In Retinitis Pigmentosamentioning

confidence: 99%

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Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

Ong

Patel

Singh

2019

JCM

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Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging modality that allows depth-resolved imaging of the microvasculature in the retina and the choroid. It is a powerful research tool to study the pathobiology of retinal diseases, including inherited retinal dystrophies. In this review, we provide an overview of the evolution of OCTA technology, compare the specifications of various OCTA devices, and summarize key findings from published OCTA studies in inherited retinal dystrophies including retinitis pigmentosa, Stargardt disease, Best vitelliform macular dystrophy, and choroideremia. OCTA imaging has provided new data on characteristics of these conditions and has contributed to a deeper understanding of inherited retinal disease.

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Section: Octa In Retinitis Pigmentosamentioning

confidence: 98%

Section: Octa In Retinitis Pigmentosamentioning

confidence: 99%

Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

Ong

Patel

Singh

2019

JCM

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“…CHM causes progressive concentric retinal and choroidal degeneration, with a characteristic preserved small island of retinal tissue at the macula until late stage of the disease. OCTA acquires simultaneous structural and angiographic data, allowing for the concurrent investigation of the outer retina and choroid [21][22][23]. In this paper, high contrast en face images were generated for direct visualisation with reliable delineation and measurement of areas of preserved EZ and CC.…”

Section: Discussionmentioning

confidence: 99%

Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches

Hagag

Mitsios

Narayan³

et al. 2020

Eye

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Objective To investigate the retinal changes in choroideremia (CHM) patients to determine correlations between age, structure and function. Subjects/Methods Twenty-six eyes from 13 male CHM patients were included in this prospective longitudinal study. Participants were divided into <50-year (n = 8) and ≥50-year (n = 5) old groups. Patients were seen at baseline, 6-month, and 1-year visits. Optical coherence tomography (OCT), OCT angiography, and fundus autofluorescence were performed to measure central foveal (CFT) and subfoveal choroidal thickness (SCT), as well as areas of preserved choriocapillaris (CC), ellipsoid zone (EZ), and autofluorescence (PAF). Patients also underwent functional investigations including visual acuity (VA), contrast sensitivity (CS), colour testing, microperimetry, dark adaptometry, and handheld electroretinogram (ERG). Vision-related quality-of-life was assessed by using the NEI-VFQ-25 questionnaire. Results Over the 1-year follow-up period, progressive loss was detected in SCT, EZ, CC, PAF, and CFT. Those ≥50-years exhibited more structural and functional defects with SCT, EZ, CC, and PAF showing strong correlation with patient age (rho ≤ −0.47, p ≤ 0.02). CS and VA did not change over the year, but CS was significantly correlated with age (rho = −0.63, p = 0.001). Delayed to unmeasurable dark adaptation, decreased colour discrimination and no detectable ERG activity were observed in all patients. Minimal functional deterioration was observed over one year with a general trend of slower progression in the ≥50-years group. Conclusions Quantitative structural parameters including SCT, CC, EZ, and PAF are most useful for disease monitoring in CHM. Extended follow-up studies are required to determine longitudinal functional changes.

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“…Several recent studies conducted with OCTA have reported a reduction of retinal vessel density and retinal perfusion density, impaired choroidal blood flow, or significantly altered sizes of the foveal avascular zones in eyes of patients suffering from RP [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Given the known microvascular alterations in RP, it might be beneficial to use OCTA in the context of TES treatment.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa

Zabek

Zuche

Müller

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose Transcorneal electrical stimulation (TES) is a novel treatment approach for patients with retinitis pigmentosa (RP). The aim of our study was to observe changes in optical coherence tomography angiography (OCTA) that would be attributed to TES treatment. Methods A total of 73 eyes were included: 43 eyes of 22 subjects (11 ♀, 11 ♂) suffering from RP were examined at baseline (BL), after first stimulation (TS), 1 week (1W), and 6 months (6M) after treatment initiation and were compared with 30 control eyes of 15 subjects (8 ♀, 7 ♂). TES was performed simultaneously on both eyes for 30 min weekly. OCTA scans of 9 × 15 mm were recorded with a PLEX Elite 9000 swept-source OCTA device (Carl Zeiss Meditec AG, Jena). Vascular density metrics such as perfusion density (PD) and vessel density (VD) were calculated automatically for the macular area by using standardised extended early treatment diabetic retinopathy study (ETDRS) grids centred around the fovea. In addition, the capillary perfusion density (CPD) and the capillary flux index (CFI) of the peripapillary nerve fibre layer microvasculature in all four quadrants of an annulus centred at the optic disc were measured. All parameters were determined over all retinal layers and separately for the superficial (SCP) and deep capillary plexus (DCP). ANOVA-based linear mixed-effects models were calculated with SPSS®. Results Throughout the course of TES treatment, the macular VD and PD of all retinal layers in all subsections showed a slight decrement without reaching statistical significance, also when analysed separately in the SCP and DCP (p > 0.08). In analogy, the average CPD and CFI also presented with a slight decrement (p > 0.20). However, when compared with controls, most OCTA parameters showed a significant decrement (p < 0.05). When analysed systematically in all subsections of the extended ETDRS grid, the temporal macular subsections within the outer ring (radius 1.5–3 mm) and also of the peripheral C1, C2, and C3 rings (radius 3–7.5 mm) showed lower VD and PD values when compared with the other subsections (p < 0.05). Conclusion Vascular density metrics in the macular region and the peripapillary microvasculature appear to remain unaffected by continuous TES treatment within a period of 6 months.

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Projection-Resolved Optical Coherence Tomographic Angiography of Retinal Plexuses in Retinitis Pigmentosa

Cited by 32 publications

References 64 publications

Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches

Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa

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