Projections from bed nuclei of the stria terminalis, magnocellular nucleus: Implications for cerebral hemisphere regulation of micturition, defecation, and penile erection

Dong, Hong‐Wei; Swanson, Larry W.

doi:10.1002/cne.20789

Cited by 88 publications

(65 citation statements)

References 127 publications

(199 reference statements)

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“…In the septal area, unlesioned aggressive dams showed significantly more Fos-labeled cells in the ventral part of the anterior division of the bed nuclei of the stria terminalis (BSTv; Fig. 4C; P = 0.0032), which encompasses the dorsomedial, anteromedial, magnocellular, and ventral nuclei (11)(12)(13). In the hypothalamus, in addition to the PMv, unlesioned dams displaying maternal aggression had a significantly greater number of Fos-immunoreactive cells in the medial preoptic nucleus (MPN; Fig.…”

Section: Brain Fos Expression In Unlesioned Andmentioning

confidence: 99%

Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network

Motta¹,

Furigo²,

Sukikara

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Maternal aggression is under the control of a wide variety of factors that prime the females for aggression or trigger the aggressive event. Maternal attacks are triggered by the perception of sensory cues from the intruder, and here we have identified a site in the hypothalamus of lactating rats that is highly responsive to the male intruder-the ventral premammillary nucleus (PMv). The PMv is heavily targeted by the medial amygdalar nucleus, and we used lesion and immediate-early gene studies to test our working hypothesis that the PMv signals the presence of a male intruder and transfers this information to the network organizing maternal aggression. PMv-lesioned dams exhibit significantly reduced maternal aggression, without affecting maternal care. The Fos analysis revealed that PMv influences the activation of hypothalamic and septal sites shown to be mobilized during maternal aggression, including the medial preoptic nucleus (likely to represent an important locus to integrate priming stimuli critical for maternal aggression), the caudal two-thirds of the hypothalamic attack area (comprising the ventrolateral part of the ventromedial hypothalamic nucleus and the adjacent tuberal region of the lateral hypothalamic area, critical for the expression of maternal aggression), and the ventral part of the anterior bed nuclei of the stria terminalis (presently discussed as being involved in controlling neuroendocrine and autonomic responses accompanying maternal aggression). These findings reveal an important role for the PMv in detecting the male intruder and how this nucleus modulates the network controlling maternal aggression. P ostpartum rats are highly aggressive toward other animals that enter the vicinity of their nest and pups, with the presumed function of protecting their offspring from harm (1). Maternal aggression is under the control of a wide variety of factors that prime the females for aggression or trigger the aggressive event. The priming of maternal aggression in laboratory rats relies first on the hormonal changes associated with late pregnancy and parturition, and then on exteroceptive stimulation from the pups (2-6). Maternal attacks are triggered by the perception of polymodal sensory cues from the intruder (7). Information from the main olfactory pathway is crucial for high maternal aggression, although any importance for accessory olfactory inputs is less clear (5, 6). Furthermore, somatosensory signaling from the perioral region of the dams' face while they investigate an intruder is critical for attacks (8).Considering the overlap of sensory modalities involved in how offspring cues prime maternal aggression and those involved in how intruders trigger aggressive behavior, experimental approaches that permanently destroy a sensory system are difficult to interpret because the result observed could be due to altered priming or altered triggering of the behavior. For that reason, identifying a brain area that specifically responds to the intruder as a threat would clarify what sensory info...

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Section: Brain Fos Expression In Unlesioned Andmentioning

confidence: 99%

Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network

Motta¹,

Furigo²,

Sukikara

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Slices were continuously superfused (4-5 ml min 10 HEPES, 0.5 EGTA, 2 MgATP, 0.3 Na-GTP, 20 phosphocreatine, pH 7.3 with KOH). CRFR2-pBNST cells were identified by tdTomato expression.…”

Section: In Vitro Electrophysiological Recordingmentioning

confidence: 99%

“…Notably, the BNST is a very heterogeneous conglomerate of subnuclei, which serve various functions through their diversity in cellular sub-populations and input and projection sites. 3,4,[7][8][9][10] In particular, the anterior and posterior sections of the BNST serve opposing roles in the mediation of the hypothalamus-pituitary-adrenal (HPA) axis. Whereas the anterior section has been implicated in the activation of the HPA axis to cause corticosterone release, the posterior BNST (pBNST) is known to send GABAergic projections to the paraventricular nucleus and thereby thought to inhibit HPA axis activation.…”

Section: Introductionmentioning

confidence: 99%

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery

et al. 2016

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The bed nucleus of the stria terminalis (BNST) is critical in mediating states of anxiety, and its dysfunction has been linked to stressrelated mental disease. Although the anxiety-related role of distinct subregions of the anterior BNST was recently reported, little is known about the contribution of the posterior BNST (pBNST) to the behavioral and neuroendocrine responses to stress. Previously, we observed abnormal expression of corticotropin-releasing factor receptor type 2 (CRFR2) to be associated with post-traumatic stress disorder (PTSD)-like symptoms. Here, we found that CRFR2-expressing neurons within the pBNST send dense inhibitory projections to other stress-related brain regions (for example, the locus coeruleus, medial amygdala and paraventricular nucleus), implicating a prominent role of these neurons in orchestrating the neuroendocrine, autonomic and behavioral response to stressful situations. Local CRFR2 activation by urocortin 3 depolarized the cells, increased the neuronal input resistance and increased firing of action potentials, indicating an enhanced excitability. Furthermore, we showed that CRFR2-expressing neurons within the pBNST are critically involved in the modulation of the behavioral and neuroendocrine response to stress. Optogenetic activation of CRFR2 neurons in the pBNST decreased anxiety, attenuated the neuroendocrine stress response, ameliorated stress-induced anxiety and impaired the fear memory for the stressful event. Moreover, activation following trauma exposure reduced the susceptibility for PTSD-like symptoms. Optogenetic inhibition of pBNST CRFR2 neurons yielded opposite effects. These data indicate the relevance of pBNST activity for adaptive stress recovery.

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“…Experiments analyzed for this and the accompanying papers (Dong and Swanson, 2005a,b) indicate that projection patterns from the bulk of all three regions are essentially identical as well. Considering this evidence together, we here simplify BST parcellation and nomenclature by combining into a single entity-the BST anteromedial area (BSTam)-the following components: a) the anterodorsal area, b) the anteroventral area proper of Ju and colleagues , c) the rostral third of the dorsolateral nucleus (Atlas Level 20; Swanson, 1998Swanson, -1999, d) the rostral tongue of the BST dorsomedial nucleus (Atlas Levels 16-19;Swanson, 1998Swanson, -1999; also see Dong and Swanson, 2005a), and e) the lateral two-thirds of the ventral nucleus on Atlas Level 21 of Swanson (1998Swanson ( -1999; also see Dong and Swanson, 2005b). In their original description Ju and colleagues noted a central condensation (BSTcc) in the anterodorsal area.…”

Section: Nomenclaturementioning

confidence: 99%

“…Here we focus on the anteromedial area (BSTam), the relatively undifferentiated region of the anterior medial (anteromedial) group (BSTamg), which also includes the more distinct dorsomedial nucleus (Dong and Swanson, 2005a) and the magnocellular and ventral nuclei (Dong and Swanson, 2005b). The overall organization of BSTam projections has not been examined previously.…”

Section: Introductionmentioning

confidence: 99%

Projections from bed nuclei of the stria terminalis, anteromedial area: Cerebral hemisphere integration of neuroendocrine, autonomic, and behavioral aspects of energy balance

2005

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The anteromedial area of the bed nuclei of the stria terminalis (BSTam) is the relatively undifferentiated region of the anterior medial (anteromedial) group of the bed nuclei of the stria terminalis (BSTamg), which also includes the more distinct dorsomedial, magnocellular, and ventral nuclei. The overall pattern of axonal projections from the rat BSTam was analyzed with the PHAL anterograde pathway tracing method. Brain areas receiving relatively moderate to strong inputs from the BSTam fall into five general categories: neuroendocrine system (regions containing pools of magnocellular oxytocin neurons, and parvicellular corticotropin-releasing hormone, thyrotropin-releasing hormone, somatostatin, and dopamine neurons); central autonomic control network (central amygdalar nucleus, descending paraventricular nucleus, and ventrolateral periaqueductal gray); hypothalamic visceromotor pattern generator network (5 of 6 known components); behavior control column (descending paraventricular nucleus and associated arcuate nucleus; ventral tegmental area and associated nucleus accumbens and substantia innominata); and behavioral state control (supramammillary and tuberomammillary nuclei). The BSTam projects lightly to thalamocortical feedback loops (via the medial-midline-intralaminar thalamus). Its pattern of axonal projections, combined with its pattern of neural inputs (the most varied of all BST cell groups), suggest that the BSTam is part of a striatopallidal differentiation involved in coordinating neuroendocrine, autonomic, and behavioral or somatic responses associated with maintaining energy balance homeostasis.

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Projections from bed nuclei of the stria terminalis, magnocellular nucleus: Implications for cerebral hemisphere regulation of micturition, defecation, and penile erection

Cited by 88 publications

References 127 publications

Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network

Ventral premammillary nucleus as a critical sensory relay to the maternal aggression network

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery

Projections from bed nuclei of the stria terminalis, anteromedial area: Cerebral hemisphere integration of neuroendocrine, autonomic, and behavioral aspects of energy balance

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