Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis (medullary dorsal horn) and other lower brainstem areas in rats

Akhter, Fatema; Haque, Tahsinul; Satô, Fumihiko; Kato, Takafumi; Ohara, Hisanori; Fujio, T.; Tsutsumi, Kenjirō; Uchino, Katsuro; Sessle, Barry J.; Yoshida, Atsushi

doi:10.1016/j.neuroscience.2014.01.046

Cited by 27 publications

(20 citation statements)

References 81 publications

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“…Although little is known about the function of DP, which occupies a large area rostrocaudally (Paxinos and Watson 2007). consistent with our suggestion two recent detailed anatomical studies in rat and mouse suggest DP is distinct from other mPFC regions (Zingg et al 2014; Akhter et al 2014). …”

Section: Discussionsupporting

confidence: 94%

Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat

Gretenkord

Rees

Whittington

et al. 2017

Journal of Neurophysiology

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Section: Discussionsupporting

confidence: 94%

Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat

Gretenkord

Rees

Whittington

et al. 2017

Journal of Neurophysiology

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“…Curiously, the dorsal peduncular cortex, together with the taenia tecta, is one of the very few areas of the rostral telencephalon of mammals reciprocally connected with the olfactory bulb (Shipley, Ennis, & Puche, ; this area is dorsally adjacent to the taenia tecta and is often included as part of the prefrontal cortex; De Carlos, López‐Mascaraque, & Valverde, ), thus resembling in its relative position and its reciprocal olfactory bulb connection the avian Md and the lizard rostral DLP. Moreover, the dorsal peduncular cortex is reciprocally connected with the granular/dysgranular part of the insular cortex, and both project to the same brainstem targets (Akhter et al, ). Perhaps they represent rostral and intermediate parts of the mammalian DLP (Table ).…”

Section: Discussionmentioning

confidence: 99%

Expression of regulatory genes in the embryonic brain of a lizard and implications for understanding pallial organization and evolution

Desfilis

Abellán

Sentandreu

et al. 2017

J of Comparative Neurology

179

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The comparison of gene expression patterns in the embryonic brain of mouse and chicken is being essential for understanding pallial organization. However, the scarcity of gene expression data in reptiles, crucial for understanding evolution, makes it difficult to identify homologues of pallial divisions in different amniotes. We cloned and analyzed the expression of the genes Emx1, Lhx2, Lhx9, and Tbr1 in the embryonic telencephalon of the lacertid lizard Psammodromus algirus. The comparative expression patterns of these genes, critical for pallial development, are better understood when using a recently proposed six‐part model of pallial divisions. The lizard medial pallium, expressing all genes, includes the medial and dorsomedial cortices, and the majority of the dorsal cortex, except the region of the lateral cortical superposition. The latter is rich in Lhx9 expression, being excluded as a candidate of dorsal or lateral pallia, and may belong to a distinct dorsolateral pallium, which extends from rostral to caudal levels. Thus, the neocortex homolog cannot be found in the classical reptilian dorsal cortex, but perhaps in a small Emx1‐expressing/Lhx9‐negative area at the front of the telencephalon, resembling the avian hyperpallium. The ventral pallium, expressing Lhx9, but not Emx1, gives rise to the dorsal ventricular ridge and appears comparable to the avian nidopallium. We also identified a distinct ventrocaudal pallial sector comparable to the avian arcopallium and to part of the mammalian pallial amygdala. These data open new venues for understanding the organization and evolution of the pallium.

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“…However, the DP occupies a large area in the rostral-caudal direction in the PFC above the tenia tecta (Paxinos & Watson 2007). Two recent anatomical studies have described in detail a distinct connectivity of the DP (Akhter et al 2014;Zingg et al 2014). These studies have shown that DP receives inputs from the posterior insula cortex and lateral entorhinal cortex (Zingg et al 2014) and that its connectivity is distinct from the IL (Akhter et al 2014), suggesting DP and IL mediate separate PFC functions.…”

Section: The Role Of Dpmentioning

confidence: 99%

“…In particular, the dorsal regions of mPFC have been implicated in working memory and attentional tasks, while more ventral regions are linked to visceral and autonomic functions (Heidbreder & Groenewegen 2003). Underlying these functional differences are clear anatomical differences between the dorsal and ventral mPFC both in terms of efferent and afferent projections and cytoarchitecture (van Eden and Uylings 1985;Uylings et al 2003;Heidbreder & Groenewegen 2003;Vertes 2004;Gabbott et al 2005;Hoover & Vertes 2007;Akhter et al 2014;Zinng et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro

Glykos

Whittington

LeBeau

2015

The Journal of Physiology

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Key points Fast network oscillations in the beta (20–30 Hz) frequency range can be evoked with combined activation of muscarinic and kainate receptors in different subregions of the medial prefrontal cortex (mPFC). Subregional differences were observed as the oscillations in the dorsal prelimbic cortex (PrL) were smaller in magnitude than those in the ventral dorsopeduncular (DP) region, and these differences persisted in trimmed slices containing only PrL and DP regions.Oscillations in both regions were dependent upon GABAA and AMPA receptor activation but NMDA receptor blockade decreased oscillations only in the DP region.Subregional differences in neuronal properties of the presumed pyramidal cells were found between PrL and DP, with many more cells in DP firing rhythmically compared to the PrL region.Presumed inhibitory synaptic potentials (IPSPs) recorded from principal cells were more rhythmic and coherent, and significantly larger in amplitude, in the DP region; the data suggest that variation in the patterns of activity between subregions may reflect distinct functional roles. AbstractFast network oscillations in the beta (20–30 Hz) and low gamma (30–80 Hz) range underlie higher cognitive functions associated with the medial prefrontal cortex (mPFC) including attention and working memory. Using a combination of kainate (KA, 200 nm) and the cholinergic agonist carbachol (Cb, 10 μm) fast network oscillations, in the beta frequency range, were evoked in the rat mPFC in vitro. Oscillations were elicited in the prelimbic (PrL), infralimbic (IL) and the dorsopeduncular (DP) cortex, with the largest oscillations observed in DP cortex. Oscillations in both the PrL and DP were dependent, with slightly different sensitivities, on γ‐aminobutyric acid (GABA)A, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) and kainate receptors, but only oscillations in the DP were significantly reduced by N‐methyl‐d‐aspartate (NMDA) receptor blockade. Intracellular recordings showed that 9/20 regular spiking (RS) cells in the PrL exhibited a notable cAMP‐dependent hyperpolarisation activated current (I h) in contrast to 16/17 in the DP cortex. Extracellular single unit recordings showed that the majority of cells in the PrL, and DP regions had interspike firing frequencies (IFFs) at beta (20–30 Hz) frequencies and fired at the peak negativity of the field oscillation. Recordings in DP revealed presumed inhibitory postsynaptic potentials (IPSPs) that were larger in amplitude and more rhythmic than those in the PrL region. Our data suggest that each PFC subregion may be capable of generating distinct patterns of network activity with different cell types involved. Variation in the properties of oscillations evoked in the PrL and DP probably reflects the distinct functional roles of these different PFC regions.

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Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis (medullary dorsal horn) and other lower brainstem areas in rats

Cited by 27 publications

References 81 publications

Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat

Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat

Expression of regulatory genes in the embryonic brain of a lizard and implications for understanding pallial organization and evolution

Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro

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