Projections from the nucleus and tractus solitarius in the cat

Cottle, Merva K.; Calaresu, F. R.

doi:10.1002/cne.901610202

Cited by 95 publications

(23 citation statements)

References 38 publications

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“…Thus, the data here support Morest [1967] who traced degeneration to the N. intercalatus, challenged by Loewy and Burton [1978]. Similarly, support is given to the involvement of the dorsal nucleus of the vagus [Cottle and Calaresu, 1975] which was denied by Morest [1967], The same differences and findings indicate that bilateral descending pathways exist to this level.…”

Section: Discussionsupporting

confidence: 84%

Some Observations on the Nature of Neural Intranuclear Inclusions (Roncoroni Bodies)

Penner¹

1983

Cells Tissues Organs

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In experimental jejunal obstruction produced in cats, the neurones of the intermediate gray column of the cord showed bilateral intranuclear inclusions. They were also seen when hypertrophy and hyperplasia, produced in various elements of the bowel wall, were prevented by large doses of atropine. The latter observation implied that the afferent autonomic nerve supply is involved in the production of these unusual structures. The inclusion bodies were extremely rare or absent in control animals. In order to see whether these bodies occurred by chance even though they are regularly produced in the above-mentioned area, an effort was made to see whether they would appear unilaterally following stimulation of a unilateral afferent nerve. This was done by ligation and severance of the right common carotid artery below its bifurcation with or without severing its accompanying vagal trunk. Removal of the pulsatile blood supply to the carotid sinus and carotid body has long been known to produce afferent action potentials in the glossopharyngeal and vagus nerves. Within 6 h many neurones in the middle half of the ipsilateral nucleus of the tractus solitarius showed the inclusions. The cephalic end of this nucleus showed no inclusions. At the level of the obex the inclusions were present bilaterally. The inclusions also appeared in numerous other areas of the brain, brain stem and cervical cord in bilateral fashion. They were found in neurones of the neurohyphysis as well as in the cingulate gyrus. Their widespread but focal distribution corresponds to numerous areas of the cord and brain in which physiologists have produced striking effects with electric probing and stimulation. The inclusion bodies are at present conceived as representing the neuronal nuclear response to an afferent stimulus which causes an increase in the metabolic activity controlled by the nucleus.

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Section: Discussionsupporting

confidence: 84%

Some Observations on the Nature of Neural Intranuclear Inclusions (Roncoroni Bodies)

Penner¹

1983

Cells Tissues Organs

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“…The afferents from the vagal pathway generally input to the nucleus tractus solitarius (NTS), of which electrical activity influenced on the medullary respiratory neuron groups and dorsal nucleus of the vagus and, elicit various cardiorespiratory responses [23,28]. At present, we cannot describe whether the afferent informations associated with CAPS and water stimuli which arose from the larynx in the dog terminate polymodal neurons in the NTS as observed in the spinal dorsal horn neurons [13].…”

Section: Discussionmentioning

confidence: 96%

Cardiovascular Reflex Mechanisms by Topical Instillation of Capsaicin and Distilled Water into the Larynx in Anesthetized Dogs.

et al. 1997

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ABSTRACT. Cardiovascular reflex mechanisms by topical laryngeal instillation of capsaicin (CAPS) or distilled water were evaluated in anesthetized chronic tracheostomized dogs. Both CAPS (10 µg/ml) and water instillation into the isolated upper airway caused a significant decrease in heart rate (P<0.05) and a significant increase in blood pressure (P<0.05) from the values before instillation under both spontaneous and controlled ventilation. The bradycardia was significantly reduced by atropine pretreatment (P<0.05) and the hypertension was significantly decreased by phentolamine and propranolol pretreatments (P<0.01). A higher concentration of CAPS (100 µg/ml) instillation considerably reduced the response to subsequent CAPS (100 µg/ml) instillation, whereas the response to water was sustained, indicating the desensitization of laryngeal CAPS-sensitive endings. All the reflex responses to CAPS and water were eliminated by topical anesthesia with lidocaine. It was concluded that the laryngeal cardiovascular reflex responses were mediated by the afferents such as the laryngeal CAPS-sensitive presumably C-fiber endings or water-responsive receptors and by both the parasympathetic and sympathetic nervous systems as efferents. -KEY WORDS: autonomic nervous blockade, canine, cardiovascular reflex, capsaicin, distilled water.J. Vet. Med. Sci. 59(9): 801-806, 1997 weight was 11.5 kg (ranging from 7.5 to 14.0 kg). Food was withheld at least 12 hours before each experiment. Surgical procedure for in vivo isolated upper airway model: All the dogs underwent permanent tracheostomy 2-3 weeks before experiments. Dogs were induced anesthesia with a thiopental sodium (25 mg/kg; RAVONAL ® , Tanabe, Japan) intravenously, endotracheally intubated, followed by maintained anesthesia with isoflurane in 100% oxygen. An Window surgical technique for permanent tracheostomy was used in this study [14,19]. Briefly, dogs were placed on an operating table in the spine position, and midline skin incision was made with an oval piece of the skin. Sternohyoid muscles were separated and the ventral aspect of the trachea was exposed. Then the medial edges of sternohyoid muscle were sutured together at the dorsal to the trachea for the elevation to the skin by horizontal mattress sutures with 3-0 non-absorbable polypropylene monofilament. The ventral aspect of three tracheal rings just mid portion of the trachea between cricoid cartilage and thoracic wall leaving the tracheal mucosa intact. After the tracheal rings were completely removed, the mucosa was completely dissected approximately 5 mm margin left from the trachea. Then the skin and trachea including mucosa were sutured with 3-0 polypropylene monofilament. Butorphanol (0.2 mg/kg; STADOL ® , Bristol-Myears Squibb Co., Japan) was injected intramuscularly as postoperative analgesia. During the adjustment period after surgery, tracheostomy site was carefully cleaned and nebulized with saline solution if necessary. Dogs fed in an isolated room and received ampycillin (20 mg/kg × 2/day; PENTR...

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“…the parabrachial nuclei, and the lateral groups of respiratory neurones in the nucleus ambiguus and nucleus retroambigualis in the medulla oblongata. Pathways between these groups of neurones have been demonstrated anatomically (Morest, 1967;Cottle & Calaresu, 1975;Kalia, 1977;Loewy & Burton, 1978;Norgren, 1978;King, 1980). In addition, respiratory neurones in pontine nuclei have been shown to be strongly inhibited by pulmonary afferents (Feldman, Cohen, & Wolotsky, 1976), although there is no evidence that this is a direct pathway from medulla to pons.…”

Section: Discussionmentioning

confidence: 99%

The brain‐stem projections of pulmonary stretch afferent neurones in cats and rabbits.

Donoghue¹,

García²,

Jordan³

et al. 1982

The Journal of Physiology

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SUMMARY1. Micro-electrode recordings were made from slowly adapting pulmonary stretch afferents within the nodose ganglia of cats and rabbits. Recording sites were distributed throughout the ganglia.2. The projections of these afferents to the medulla oblongata were studied by antidromic stimulation. 'Point' and 'Field' type depth-threshold curves were interpreted as corresponding to stimulation of the main afferent axon and its branches, respectively. Increases in antidromic latency in conjunction with 'field' contours was additional evidence in support of this interpretation.3. In cats, most (six out of seven) afferents had extensive branches, and probably also terminations, within the medial subnucleus of the ipsilateral nucleus tractus solitarius (n.t.s.). Two of these, plus one other afferent, also had projections to the lateral and ventrolateral subnuclei.4. In rabbits the projections of such afferents were similar, i.e. mainly to the medial subnucleus of the n.t.s. (eight out of eleven) but also extending into the nucleus alaris, and occasionally to lateral and ventrolateral subnuclei (two out of eleven) or to both regions (one out of eleven).5. Branching of single afferents was seen to occur over up to 3 mm of the rostro-caudal extent of the intermediate region of the n.t.s. The significance of the observations is discussed.

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Projections from the nucleus and tractus solitarius in the cat

Cited by 95 publications

References 38 publications

Some Observations on the Nature of Neural Intranuclear Inclusions (Roncoroni Bodies)

Some Observations on the Nature of Neural Intranuclear Inclusions (Roncoroni Bodies)

Cardiovascular Reflex Mechanisms by Topical Instillation of Capsaicin and Distilled Water into the Larynx in Anesthetized Dogs.

The brain‐stem projections of pulmonary stretch afferent neurones in cats and rabbits.

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