Projections from the superior olive and lateral lemniscus to tonotopic regions of the rat's inferior colliculus

Kelly, Jack B.; Liscum, Allan; Adel, Brian van; Ito, Makoto

doi:10.1016/s0378-5955(97)00195-0

Cited by 95 publications

(82 citation statements)

References 74 publications

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“…Thus, unlike most of the nuclei within the central auditory system, the VNLL of the rat does not show any simple tonotopic progression along its major structural axis. This result is consistent with anatomical findings that show a wide distribution of retrograde labeling along the dorsoventral length of VNLL after small injections of tracer into frequencyspecific regions of the central nucleus of the inferior colliculus (Kelly et al 1998;Malmierca et al 1998). The lack of tonotopic gradient is also supported by functional labeling studies using c-fos (Friauf 1992;Glendenning and Hutson 1998;Saint Marie et al 1999).…”

Section: Frequency-tuning Curvessupporting

confidence: 91%

“…However, neither metabolic mapping with 2-DG nor sound-induced c-fos expression has suggested the presence of a tonotopic gradient in the rat's VNLL (Friauf 1992;Saint Marie et al 1999). Also, retrograde tract tracing from frequency-specific regions of the inferior colliculus results in distributed labeling along the length of VNLL, suggesting a diffuse frequency representation (Kelly et al 1998;Malmierca and Merchán 2004;Merchán and Berbel 1996).…”

Section: Introductionmentioning

confidence: 94%

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Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

Zhang

Kelly²

2006

Journal of Neurophysiology

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Zhang, Huiming and Jack B. Kelly. Responses of neurons in the rat's ventral nucleus of the lateral lemniscus to monaural and binaural tone bursts. J Neurophysiol 95: 2501-2512, 2006. First published January 4, 2006 doi:10.1152/jn.01215.2005. Responses to monaural and binaural tone bursts were recorded from neurons in the rat's ventral nucleus of the lateral lemniscus (VNLL). Most of the neurons (55%) had V-or U-shaped frequency-tuning curves with a single clearly defined characteristic frequency (CF). However, many neurons had more complex, multipeaked tuning curves (37%), or other patterns (8%). Temporal firing patterns included both onset and sustained responses to contralateral tone bursts. Onset and sustained responses were distributed along the dorsoventral length of VNLL with no indication of segregation into different regions. Onset neurons had shorter average first-spike latencies than neurons with sustained responses (means, 8.3 vs. 14.8 ms). They also had less jitter, as reflected in the SD of first-spike latencies, than neurons with sustained responses (means, 0.59 and 4.2 ms, respectively). The extent of jitter decreased with an increase in stimulus intensity for neurons with sustained responses, but remained unchanged for onset neurons tested over the same range. Many neurons had binaural responses, primarily of the excitatory/inhibitory (EI) type, widely distributed along the dorsoventral extent of VNLL. Local application of the AMPA receptor antagonist NBQX reduced excitatory responses, indicating that responses were dependent on synaptic activity and not recorded from passing fibers. The results show that many neurons in VNLL have a precision of timing that is well suited for processing auditory temporal information. In the rat, these neurons are intermingled among cells with less precise temporal response features and include cells with binaural as well as monaural responses. I N T R O D U C T I O NThe ventral nucleus of the lateral lemniscus (VNLL), a prominent structure in the auditory brain stem, consists of a discrete collection of neurons located along the pathway from cochlear nucleus to inferior colliculus. The VNLL receives major afferent projections from the contralateral ventral cochlear nucleus (VCN), the ipsilateral medial nucleus of the trapezoid body (MNTB), and other ipsilateral periolivary nuclei, but does not receive projections from the medial or lateral superior olives, two nuclei that have been shown to be important for binaural processing in the auditory system

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Section: Frequency-tuning Curvessupporting

confidence: 91%

Section: Introductionmentioning

confidence: 94%

Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

Zhang

Kelly²

2006

Journal of Neurophysiology

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“…In adult cats and ferrets, unilateral destruction of the inferior colliculus severely disrupts sound localization with the effects most apparent in the spatial field contralateral to the side of the lesion (Jenkins and Masterton, 1982;Kelly and Kavanagh, 1994). Comparable data are not available for adult rats, but one might expect severe deficits after unilateral IC lesions considering the deficits in sound localization produced by unilateral damage of binaural structures with direct projections to the IC, viz., the superior olivary complex and the dorsal nucleus of the lateral lemniscus (Ito et al, 1996;Kelly et al, 1996;van Adel and Kelly, 1998). …”

Section: Methodsmentioning

confidence: 99%

“…Three principal nuclei comprise the SOC in the rat: the lateral superior olive (LSO), the medial superior olive (MSO), and the superior paraolivary nucleus (SPN). In the rat, as in many other mammals, these three nuclei (LSO, MSO and SPN) constitute part of the main ascending afferent sources of projections to the inferior colliculus (IC) (Adams, 1979;Glendenning and Masterton, 1983;Kelly et al, 1998;Moore et al, 1995;Pollak et al, 2002). The major excitatory inputs to the IC emerge from the ipsilateral MSO and contralateral LSO.…”

Section: Introductionmentioning

confidence: 99%

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

et al. 2008

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Anatomical plasticity of projections from brainstem auditory structures to the inferior colliculus (IC) was examined in albino rats to determine the effects of unilateral destruction of the IC during early development. The IC in the right hemisphere was destroyed by aspiration on postnatal day 3. Upon reaching adulthood, the rats were examined by retrograde tract tracing methods with fluoro-gold (FG) and [

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“…The arrangement of incoming lemniscal fibers as afferent layers and their association with the underlying cellular architecture of the central nucleus together constitute fibrodendritic laminae FayeLund and Osen, 1985;Oliver et al, 1991;Malmierca et al, 1993). This laminar organization preserves the frequency order of the cochlea (Clopton and Winfield, 1973;Merzenich and Reid, 1974;Semple and Aitkin, 1979;Huang and Fex, 1986;Ryan et al, 1988;Kelly et al, 1998). Several inputs terminate primarily within alternating sublayers of neighboring lamina, thereby giving the projection distribution a banded or patchy appearance.…”

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confidence: 99%

Plasticity in the Development of Afferent Patterns in the Inferior Colliculus of the Rat after Unilateral Cochlear Ablation

2000

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The central nucleus of the inferior colliculus (IC) is the site of convergence for nearly all ascending monaural and binaural projections. Several of these inputs, including inhibitory connections from the dorsal nucleus of the lateral lemniscus (DNLL), are highly ordered and organized into series of afferent bands or patches. Although inputs to the IC from the contralateral DNLL are present in the rat by birth [postnatal day 0 (P0)], the earliest indications of band formation are not evident until P4. Subsequently, the initially diffuse projection segregates into a pattern of bands and interband spaces, and by P12 adult-like, afferentdense patches are established . To determine the role of the auditory periphery in the development of bands and patches before the onset of hearing (P12/P13), unilateral cochlear ablations were performed at P2 (before any evidence of banding). Rat pups were reared to P12, at which timeglasspinscoatedwith1,1Ј-dioctodecyl-3,3,3Ј,3Ј-tetramethylindocarbocyanine perchlorate were placed in fixed tissue in the commissure of Probst where DNLL fibers cross the midline. The results indicate that a unilateral cochlear ablation disrupts the normal development of afferent patches in the IC. Although the crossed DNLL projections labeled via commissural dye placement always mirrored each other in P12 controls, ablation cases exhibited a consistent, bilateral asymmetry in pattern formation and relative density of the labeled projections. Possible developmental mechanisms likely to be involved in the establishment of afferent bands and patches before the onset of hearing are discussed.Key words: afferent patterns; inferior colliculus; DNLL; cochlear ablation; auditory midbrain; commissure of Probst; carbocyanine dye; bands; patches; rat The inferior colliculus (IC) is the site of convergence for nearly all ascending and descending auditory pathways. Based on regional variations in cellular anatomy, neuropil, and afferent and efferent connectivity, the auditory midbrain can be broken down into nuclear subdivisions Oliver and Morest, 1984), each with its distinct hierarchy of organization. The central nucleus of the IC (see Fig. 1) receives inputs from essentially all ascending pathways en route to higher auditory centers of thalamus and cortex. The majority of neurons residing within the central nucleus exhibit disk-shaped dendritic arbors that are oriented parallel to the numerous afferent fibers. The arrangement of incoming lemniscal fibers as afferent layers and their association with the underlying cellular architecture of the central nucleus together constitute fibrodendritic laminae FayeLund and Osen, 1985;Oliver et al., 1991;Malmierca et al., 1993). This laminar organization preserves the frequency order of the cochlea (Clopton and Winfield, 1973;Merzenich and Reid, 1974;Semple and Aitkin, 1979;Huang and Fex, 1986;Ryan et al., 1988;Kelly et al., 1998). Several inputs terminate primarily within alternating sublayers of neighboring lamina, thereby giving the projection distribution a banded or...

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Projections from the superior olive and lateral lemniscus to tonotopic regions of the rat's inferior colliculus

Cited by 95 publications

References 74 publications

Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

Plasticity in the Development of Afferent Patterns in the Inferior Colliculus of the Rat after Unilateral Cochlear Ablation

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